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An idiot's guide to lead optimisation for proteins

https://magnusross.github.io/posts/protein-lead-optimisation-1/
16•magni121•2d ago

I Moved My Digital Stack to Europe

https://monokai.com/articles/how-i-moved-my-digital-stack-to-europe/
343•monokai_nl•2h ago•235 comments

Why I'm leaving GitHub for Forgejo

https://jorijn.com/en/blog/leaving-github-for-forgejo/
101•jorijn•1h ago•64 comments

Preserving Fisher-Price Pixter

https://dmitry.gr/?r=05.Projects&proj=37.%20Pixter
98•dmitrygr•2d ago•10 comments

New stainless steel can survive conditions for hydrogen production in seawater

https://www.sciencedaily.com/releases/2026/05/260510030950.htm
153•HardwareLust•2d ago•53 comments

Dutch suicide prevention website shares data with tech companies without consent

https://nltimes.nl/2026/05/13/dutch-suicide-prevention-hotline-shares-visitor-data-tech-companies
53•giuliomagnifico•1h ago•25 comments

An idiot's guide to lead optimisation for proteins

https://magnusross.github.io/posts/protein-lead-optimisation-1/
16•magni121•2d ago•0 comments

Restore full BambuNetwork support for Bambu Lab printers

https://github.com/FULU-Foundation/OrcaSlicer-bambulab
538•Murfalo•16h ago•235 comments

Deterministic Fully-Static Whole-Binary Translation Without Heuristics

https://arxiv.org/abs/2605.08419
242•matt_d•9h ago•57 comments

Googlebook

https://googlebook.google/
846•tambourine_man•20h ago•1380 comments

Substrate (YC S24) Is Hiring a Technical Success Manager

https://www.ycombinator.com/companies/substrate/jobs/T2fMBhD-technical-success-manager
1•kunle•1h ago

Web Server on a Nintendo Wii

http://wii.sjmulder.nl/
47•adunk•3d ago•4 comments

Show HN: Needle: We Distilled Gemini Tool Calling into a 26M Model

https://github.com/cactus-compute/needle
536•HenryNdubuaku•19h ago•157 comments

Using OR-Tools CP-SAT for Scheduling Problems

https://atalaykutlay.com/or-tools-cp-sat-for-scheduling-problems.html
23•akutlay•2h ago•4 comments

Cost of enum-to-string: C++26 reflection vs. the old ways

https://vittorioromeo.com/index/blog/refl_enum_to_string.html
33•sagacity•5h ago•18 comments

The Boring Part of Bell Labs (2025)

https://acesounderglass.com/2025/11/15/the-boring-part-of-bell-labs/
61•surprisetalk•5d ago•6 comments

How to make your text look futuristic (2016)

https://typesetinthefuture.com/2016/02/18/futuristic/
411•_vaporwave_•17h ago•54 comments

Why senior developers fail to communicate their expertise

https://www.nair.sh/guides-and-opinions/communicating-your-expertise/why-senior-developers-fail-t...
666•nilirl•22h ago•289 comments

Reverting the incremental GC in Python 3.14 and 3.15

https://discuss.python.org/t/reverting-the-incremental-gc-in-python-3-14-and-3-15/107014
6•curiousgal•3d ago•0 comments

CERT is releasing six CVEs for serious security vulnerabilities in dnsmasq

https://lists.thekelleys.org.uk/pipermail/dnsmasq-discuss/2026q2/018471.html
343•chizhik-pyzhik•19h ago•179 comments

Software Developers Say AI Is Rotting Their Brains

https://www.404media.co/software-developers-say-ai-is-rotting-their-brains/
10•SpyCoder77•24m ago•1 comments

Scrcpy v4.0

https://github.com/Genymobile/scrcpy/releases/tag/v4.0
272•xnx•17h ago•42 comments

When “idle” isn't idle: how a Linux kernel optimization became a QUIC bug

https://blog.cloudflare.com/quic-death-spiral-fix/
125•sbulaev•14h ago•18 comments

Traceway: MIT-licensed observability stack you can self-host in ~90s

https://github.com/tracewayapp/traceway
137•sebakubisz•2d ago•30 comments

Rendering the Sky, Sunsets, and Planets

https://blog.maximeheckel.com/posts/on-rendering-the-sky-sunsets-and-planets/
505•ibobev•1d ago•40 comments

Quack: The DuckDB Client-Server Protocol

https://duckdb.org/2026/05/12/quack-remote-protocol
330•aduffy•20h ago•70 comments

The vi family

https://lpar.ATH0.com/posts/2026/05/the-vi-family/
222•hggh•1w ago•144 comments

My graduation cap runs Rust

https://ericswpark.com/blog/2026/2026-05-12-my-graduation-cap-runs-rust/
182•ericswpark•13h ago•68 comments

SecurityBaseline.eu

https://internetcleanup.foundation/2026/05/european-governments-3000-tracking-sites-1000-phpmyadm...
198•aequitas•6h ago•99 comments

The Future of Obsidian Plugins

https://obsidian.md/blog/future-of-plugins/
415•xz18r•22h ago•151 comments

Kraftwerk's radical 1976 track

https://www.bbc.com/culture/article/20260511-kraftwerks-radical-1976-track-radioactivity-became-a...
200•tcp_handshaker•14h ago•165 comments