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An idiot's guide to lead optimisation for proteins
https://magnusross.github.io/posts/protein-lead-optimisation-1/
16
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magni121
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2d ago
I Moved My Digital Stack to Europe
https://monokai.com/articles/how-i-moved-my-digital-stack-to-europe/
343
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monokai_nl
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2h ago
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235 comments
Why I'm leaving GitHub for Forgejo
https://jorijn.com/en/blog/leaving-github-for-forgejo/
101
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jorijn
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1h ago
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64 comments
Preserving Fisher-Price Pixter
https://dmitry.gr/?r=05.Projects&proj=37.%20Pixter
98
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dmitrygr
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2d ago
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10 comments
New stainless steel can survive conditions for hydrogen production in seawater
https://www.sciencedaily.com/releases/2026/05/260510030950.htm
153
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HardwareLust
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2d ago
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53 comments
Dutch suicide prevention website shares data with tech companies without consent
https://nltimes.nl/2026/05/13/dutch-suicide-prevention-hotline-shares-visitor-data-tech-companies
53
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giuliomagnifico
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1h ago
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25 comments
An idiot's guide to lead optimisation for proteins
https://magnusross.github.io/posts/protein-lead-optimisation-1/
16
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magni121
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2d ago
•
0 comments
Restore full BambuNetwork support for Bambu Lab printers
https://github.com/FULU-Foundation/OrcaSlicer-bambulab
538
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Murfalo
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16h ago
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235 comments
Deterministic Fully-Static Whole-Binary Translation Without Heuristics
https://arxiv.org/abs/2605.08419
242
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matt_d
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9h ago
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57 comments
Googlebook
https://googlebook.google/
846
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tambourine_man
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20h ago
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1380 comments
Substrate (YC S24) Is Hiring a Technical Success Manager
https://www.ycombinator.com/companies/substrate/jobs/T2fMBhD-technical-success-manager
1
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kunle
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1h ago
Web Server on a Nintendo Wii
http://wii.sjmulder.nl/
47
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adunk
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3d ago
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4 comments
Show HN: Needle: We Distilled Gemini Tool Calling into a 26M Model
https://github.com/cactus-compute/needle
536
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HenryNdubuaku
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19h ago
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157 comments
Using OR-Tools CP-SAT for Scheduling Problems
https://atalaykutlay.com/or-tools-cp-sat-for-scheduling-problems.html
23
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akutlay
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2h ago
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4 comments
Cost of enum-to-string: C++26 reflection vs. the old ways
https://vittorioromeo.com/index/blog/refl_enum_to_string.html
33
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sagacity
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5h ago
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18 comments
The Boring Part of Bell Labs (2025)
https://acesounderglass.com/2025/11/15/the-boring-part-of-bell-labs/
61
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surprisetalk
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5d ago
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6 comments
How to make your text look futuristic (2016)
https://typesetinthefuture.com/2016/02/18/futuristic/
411
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_vaporwave_
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17h ago
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54 comments
Why senior developers fail to communicate their expertise
https://www.nair.sh/guides-and-opinions/communicating-your-expertise/why-senior-developers-fail-t...
666
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nilirl
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22h ago
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289 comments
Reverting the incremental GC in Python 3.14 and 3.15
https://discuss.python.org/t/reverting-the-incremental-gc-in-python-3-14-and-3-15/107014
6
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curiousgal
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3d ago
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0 comments
CERT is releasing six CVEs for serious security vulnerabilities in dnsmasq
https://lists.thekelleys.org.uk/pipermail/dnsmasq-discuss/2026q2/018471.html
343
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chizhik-pyzhik
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19h ago
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179 comments
Software Developers Say AI Is Rotting Their Brains
https://www.404media.co/software-developers-say-ai-is-rotting-their-brains/
10
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SpyCoder77
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24m ago
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1 comments
Scrcpy v4.0
https://github.com/Genymobile/scrcpy/releases/tag/v4.0
272
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xnx
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17h ago
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42 comments
When “idle” isn't idle: how a Linux kernel optimization became a QUIC bug
https://blog.cloudflare.com/quic-death-spiral-fix/
125
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sbulaev
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14h ago
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18 comments
Traceway: MIT-licensed observability stack you can self-host in ~90s
https://github.com/tracewayapp/traceway
137
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sebakubisz
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2d ago
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30 comments
Rendering the Sky, Sunsets, and Planets
https://blog.maximeheckel.com/posts/on-rendering-the-sky-sunsets-and-planets/
505
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ibobev
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1d ago
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40 comments
Quack: The DuckDB Client-Server Protocol
https://duckdb.org/2026/05/12/quack-remote-protocol
330
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aduffy
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20h ago
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70 comments
The vi family
https://lpar.ATH0.com/posts/2026/05/the-vi-family/
222
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hggh
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1w ago
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144 comments
My graduation cap runs Rust
https://ericswpark.com/blog/2026/2026-05-12-my-graduation-cap-runs-rust/
182
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ericswpark
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13h ago
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68 comments
SecurityBaseline.eu
https://internetcleanup.foundation/2026/05/european-governments-3000-tracking-sites-1000-phpmyadm...
198
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aequitas
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6h ago
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99 comments
The Future of Obsidian Plugins
https://obsidian.md/blog/future-of-plugins/
415
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xz18r
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22h ago
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151 comments
Kraftwerk's radical 1976 track
https://www.bbc.com/culture/article/20260511-kraftwerks-radical-1976-track-radioactivity-became-a...
200
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tcp_handshaker
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14h ago
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165 comments
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