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Scientists believe ibogaine can help veterans overcome PTSD

https://www.bbc.com/future/article/20260514-how-hallucinogenic-ibogaine-helps-veterans-overcome-ptsd
14•bushwart•2h ago

Comments

bushwart•2h ago
Original title: Ibogaine is a banned hallucinogenic drug. Scientists believe it can help veterans overcome PTSD
panflute•46m ago
It seems strange to me to choose ibogaine when Salvia divinorum seems like it has a similar psychological experience without the physical heart risk.
boxed•41m ago
Or LSD, or magic mushrooms.
galangalalgol•29m ago
I've been assuming it was some sort of profit motive as TX has been pumping money into it. It seems like there might actually be science driven though. For tramatic brain injury combined with ptsd ibogaine causes a release of glial cell factors that help neuroplasticity wire around the damage. Its also horribly unsafe from a cardiac perspective so you would need a constant eeg during therapy driving up prices. So probably a little of the original motivation too.
robobro•26m ago
Saliva divinorum is inherently dysphoric due to its agonism of the kappa opiod receptor. For a different cheap legal drug that affects serotonin and the NMDA receptors like ibogaine does, there's always off label use of dextromethorphan (cough medicine)!
Trasmatta•4m ago
DXM is also the active ingredient in the antidepressant Auvelity (combined with bupropion)

Lot of interesting studies and anecdotes on its efficacy as an antidepressant

temp0826•22m ago
What? These two substances aren't even in the same ballpark.
panflute•6m ago
Maybe I have a liberal view of ballpark sizes but:

https://en.wikipedia.org/wiki/Ibogaine

"The action of ibogaine at the κ-opioid receptor may indeed contribute significantly to the psychoactive effects attributed to ibogaine ingestion; Salvia divinorum, another plant recognized for its strong hallucinogenic properties contains the chemical salvinorin A, which is a highly selective κ-opioid agonist"

dacops•8m ago
Only veterans?

I wonder about the editorial choice to use veterans rather than, say, women who have PTSD from assaults, which is a much larger group of people. (Approximately 4% of US men and 8% of US women experience PTSD every year across all reasons like accidents, sexual assaults, combat, etc.)

Presumably this treatment would help everyone? Or is it somehow supporting only vets?

vasco•5m ago
Vets kill themselves a lot so I guess it's easier to propose crazier stuff because the alternative is very bad.

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Scientists believe ibogaine can help veterans overcome PTSD

https://www.bbc.com/future/article/20260514-how-hallucinogenic-ibogaine-helps-veterans-overcome-ptsd
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