Or like a grad student didn’t dispose of their work properly and are desperately trying to distract from their scandal.
So Adamala decided to ditch the cytoskeleton. One day, while tearing through the literature, she came across an interesting mechanism in a paper (opens a new tab). By attaching protein tags to a cell membrane, the synthetic biologist Reinhard Lipowsky (opens a new tab) at the Max Planck Institute of Colloids and Interfaces attracted other proteins to crowd around and physically bend the membrane, forcing the cell to divide. Following this approach, Adamala tweaked a cell-membrane protein and tested it in her protocells. After several tries, it worked.“
This is the novel bit.
Also, go MN!
Replicating eukaryogenesis with synthetic components is something I hope to see in my lifetime.
Will they be hated? Killed off? Will they ever be see as legitimate, or just soulless beings, p-zombies.
bensyverson•1h ago
That is the holy grail? I get that the goal is to "grow" biofuels, plastic, fertilizer, drugs, or whatever else we can imagine. But is that worth the many apocalyptic sci-fi outcomes we can imagine?
TSiege•54m ago
https://en.wikipedia.org/wiki/Precision_fermentation
colordrops•47m ago
PaulHoule•39m ago
Their "minimal" cell is not quite a minimum product because it depends on prebuilt ribosomes and can't reproduce on it's own. No danger of gray goo!
This is more like it
https://www.jcvi.org/research/first-minimal-synthetic-bacter...
but those guys could probably add components to their cell to make it truly self-supporting although in biology there is a big difference between "barely works" and "high performance"
senkora•30m ago
Natural life tends to evolve, which may have consequences for production.
For example, quorn production has to be restarted from a seed population after ~1000 hours because it tends to evolve colonial variants that break the product standards: https://www.davidmoore.org.uk/21st_century_guidebook_to_fung...
TSiege•26m ago
arjie•46m ago
“Penicillin?! A poison from fungus that kills living cells?! Haven’t you played the sci fi game The Last of Us?”
Stories are stories, man. Story-logic is biased towards interesting tales. And “discovery from the natural world turned to human aims with great results” is uninteresting because we do amazing things these days.
adrian_b•41m ago
The thing that they made is more alive than a crystal, which when placed in a suitable solution will grow and reproduce its own structure, but much less alive than even the simplest known living cells.
Its "life" is similar to that of a brain-dead human, whose body is not left to die by a bunch of machines that pump air into its lungs and nutrients through its blood vessels.
The techniques developed to make this pseudo-cell might evolve eventually into techniques able to make a true cell and it is likely that valuable information can be extracted from experiments with it, but it is very unlikely that any of the ancestors of the living beings has ever had even a remote resemblance with this (because it is far too dependent on continuously receiving complex cellular components and nutrients from outside; simplified parasitic living beings could appear only when there already existed sufficiently complex living hosts for the parasites).
Some components of this thing are growing by reproducing themselves, but like I have said, so does any crystal, thus it is difficult to choose a criterion that will distinguish with certainty what is living from what is non-living.
The growth is followed by a kind of division into 2 vesicles, but that happens by a mechanism very different from any living cell. Many inorganic things will split when growing over a certain size, so again it is hard to decide whether this can be called living.
danans•28m ago
A brain-dead human is alive, but just facing systemic collapse, aka death. That's not to imply that what the scientists here have created is alive, but the comparison isn't so apt.
JumpCrisscross•38m ago
If you can disassemble and reassemble a thing, you can say you understand it. Not perfectly. But understand it. I’d imagine properly understanding rudimentary cellular biology will come with perks.
(Also, does the Holy Grail imply both a boon and a cost? Or is that just Indian Jones.)
tialaramex•3m ago
fouc•37m ago
Legend2440•35m ago
Anytime you do something interesting or useful someone accuses you of trying to build the apocalypse.
Insimwytim•27m ago
yread•24m ago