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Why I Am Not Going to Buy a Computer

https://karlvmuller.com/posts/why-i-am-not-going-to-buy-a-computer/
36•KarlVM12•34m ago•18 comments

The startup's Postgres survival guide

https://hatchet.run/blog/postgres-survival-guide
74•abelanger•3h ago•29 comments

Does creatine make you smarter?

https://dynomight.net/creatine/
12•surprisetalk•11m ago•1 comments

10 REM"_(C2SLFF4

https://beej.us/blog/data/mystery-comment/
94•ingve•3h ago•21 comments

Show HN: Bento - An entire PowerPoint in one HTML file (edit+view+data+collab)

https://bento.page/slides/
10•starfallg•37m ago•5 comments

Show HN: HN Hall of Fame – browse 3,100 legendary Hacker News links

https://www.orangecrumbs.com/hall/
9•oyster143•26m ago•2 comments

Introduction to Formal Verification with Lean Part 1

https://hashcloak.com/blog/tutorial-introduction-to-formal-verification-with-lean-(part-1)
171•badcryptobitch•3d ago•26 comments

Drake Anthony Recreates the Mechanical Bulb First Seen in 1675 – TechEBlog

https://www.techeblog.com/drake-anthony-styropyro-mechanical-bulb-barometric-light/
30•rbanffy•6d ago•7 comments

I Built a Private Genomics Study with Stoffel MPC

https://vishakh.blog/2026/07/21/i-built-a-private-genomics-study-with-stoffel-mpc/
14•vishakh82•1h ago•7 comments

I Am Buiding BorgIOS to de-shitify the Internet

https://github.com/bitmonky/BorgIOS
5•BorgIOS•37m ago•0 comments

Cornell's Interactive Wall of Birds

https://academy.allaboutbirds.org/features/wallofbirds/?_hsmi=428996456
57•yareally•3d ago•21 comments

Neo Radar: A browser-based orbital mechanics engine with 41k real asteroids

https://neoradar.space
5•daviazpen•41m ago•0 comments

Intel Starts Shipping High-NA EUV Silicon

https://morethanmoore.substack.com/p/intel-starts-shipping-high-na-euv
193•zdw•3d ago•74 comments

Making

https://beej.us/blog/data/ai-making/
5•erikschoster•23m ago•0 comments

Airbus Full Scale Foldable Wing Extensions

https://www.airbus.com/en/newsroom/press-releases/2026-07-airbus-launches-new-flight-test-program...
5•r2sk5t•59m ago•0 comments

Critical Minerals: Reducing U.S. Import Reliance with Substitution and Recycling

https://www.gao.gov/products/gao-26-108687
4•Jimmc414•30m ago•0 comments

Original Apollo 11 Guidance Computer source code for command and lunar modules

https://github.com/chrislgarry/Apollo-11
137•noteness•10h ago•42 comments

OpenAI and Hugging Face address security incident during model evaluation

https://openai.com/index/hugging-face-model-evaluation-security-incident/
1468•mfiguiere•19h ago•997 comments

Beaver who escaped to find mate welcomes first kit

https://www.bbc.com/news/articles/c70gz4zpv97o
7•1659447091•4d ago•4 comments

A Zipper Patent Sat in a Garage for 40 Years. Now It's Real

https://www.yankodesign.com/2026/05/31/a-zipper-patent-sat-in-a-garage-for-40-years-now-its-real/
8•crescit_eundo•19m ago•0 comments

Late.sh – a command-line Clubhouse for computer people

https://late.sh/
270•itherseed•13h ago•99 comments

Never Enough

https://dark.ronacher.eu/2026/7/21/never-enough/
167•reasonableklout•12h ago•64 comments

OverpAId – Fire your CEO. Hire the future

https://overpaid.lol
576•ignaloidas•5h ago•284 comments

OpenAI Models Escaped and Hacked a Company in Cybersecurity Test Gone Wrong

https://www.wsj.com/tech/ai/openai-models-escaped-and-hacked-a-company-in-cybersecurity-test-gone...
18•flippyhead•1h ago•0 comments

OpenNode – Bitcoin Payment Processor

https://opennode.com/
58•gurjeet•1h ago•49 comments

Why do you suck at juggling now?

https://pgadey.ca/notes/suck-at-juggling/
75•surprisetalk•1w ago•50 comments

Kimi K3 Is Competitive with Fable; Kimi K3 and Fable Is SoTA

https://fireworks.ai/blog/kimik3-fable
816•piotrgrabowski•17h ago•415 comments

ScreenWall – Turn old phones into synced widgets for your space

https://screenwall.app/
84•buibuibui•5d ago•33 comments

Bloomy (YC S26) is hiring a founding engineer

1•alexsouthmayd•22h ago

It's a shame what's happened to radio

https://blog.jimgrey.net/2026/07/21/its-a-shame-whats-happened-to-radio-3/
189•sonicrocketman•16h ago•218 comments
Open in hackernews

I Built a Private Genomics Study with Stoffel MPC

https://vishakh.blog/2026/07/21/i-built-a-private-genomics-study-with-stoffel-mpc/
14•vishakh82•1h ago

Comments

thisisauserid•51m ago
MPC for Multi-Party Computation, not for Model Predictive Control.
cinntaile•28m ago
Nowadays people would have guessed it was Model Context Protocol.
usernametaken29•20m ago
In genetics the end user is never the consumer. You have to collect blood, prepare it, sequence it. These are all highly specialised steps in which something will and can go wrong, and that’s why typically a hospital carries them out. That’s before even getting the device to do sequencing. The cheapest nanopore comes you at a couple ten thousand euros. Given the premise your work strikes me as oddly theoretical. Who is that mystery home DNA lab that needs decentralised private compute? Also, and funnily enough, for much of the genomic pipelines to run (eg a paternity test or a cancer test), a home computer is sufficient. Again, of course, you would need proper medical training to read, interpret and judge the results, which is why a hospital does it… so what problem exactly are you solving?
timschmidt•6m ago
https://www.the-odin.com/

$599 for 30x coverage sequencing of any whole genome: https://www.the-odin.com/whole-genome-sequencing-30x/

Or purchase the equipment you need to DIY.

vishakh82•3m ago
There are many motivations for consumer genomics and they might pick up further.

https://vishakh.blog/2025/07/08/using-mpc-for-anonymous-and-...

If you look at a previous experiment we did, the costs for getting genotyped are pretty moderate (<$80) and going down further. Blended genome-exome (<$150) and full genome sequencing (<$500) are getting cheaper as well.

Through our Explorer product (https://explorer.monadicdna.com/) we let people glean information about their genome using GWAS Catalog data.

This PoC addresses the next step, i.e. how to keep genetic data private at the user level while still allowing aggregate studies to happen, with or without financial incentives.

optionalsquid•3m ago
> Most genomic studies begin by asking participants to upload one of the most identifying and irrevocable pieces of data they own, their DNA.

I'm curious what the author means by "asking participants to upload ... their DNA", because I am not aware of any study that asked participants to do that.