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Flatworms, Ion Channels, and Burning Mouths

https://www.science.org/content/blog-post/flatworms-ion-channels-and-burning-mouths
21•surprisetalk•1d ago

Comments

yuye•1d ago
Always love reading Derek Lowe's writings. One thing confused me, though:

>These authors find that it has potent activity against the ion channel TRPM8, and that goes for other 7-nitro compounds in this series as well.

But later states

>For one thing, the other benzodiazepines aren’t much use; clonazepam really stands out on its own.

Wouldn't another 7-nitro compound also work? Flunitrazepam/Rohypnol, for example? A little bit of research shows it actually might[1].

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC13426060/

llama.cpp

https://llama.app
70•kristianpaul•1h ago•20 comments

The hardest working font in Manhattan (2025)

https://aresluna.org/the-hardest-working-font-in-manhattan/
117•dcminter•5d ago•14 comments

Compression is prediction

https://ngrok.com/blog/compression-is-prediction
442•nikolay•10h ago•180 comments

The lifesaving secret hidden inside a horseshoe crab's blue blood

https://whdh.com/news/the-lifesaving-secret-hidden-inside-a-horseshoe-crabs-blue-blood-and-the-ra...
60•andsoitis•4h ago•13 comments

WorldClaw Agentic 3D open-world generation at scale

https://tencent-hunyuan.github.io/Hunyuan3D-WorldClaw/
189•EwanG•8h ago•58 comments

Nvidia Nemotron 3.5 Lightning and NeMo Switchyard

https://blogs.nvidia.com/blog/nemotron-lightning-switchyard-rtx-dgx/
211•droidjj•10h ago•110 comments

Stealing Reasoning Traces from Proprietary LLM APIs

https://stolen-thoughts.com/
582•quantumgarbage•17h ago•261 comments

Mojo 1.0

https://www.modular.com/blog/modular-26-5-mojo-1-0-is-here
357•dayanruben•13h ago•163 comments

The Human Is the Loop

https://brentfitzgerald.com/posts/the-human-is-the-loop/
53•burnto•4h ago•21 comments

OpenAI’s head of ethics leaves less than a year after joining

https://www.ft.com/content/e49dfb75-f841-4466-a577-f7aaff8779a0
372•ilamont•18h ago•384 comments

Company Offering '100% Human-Written, Never AI' Medical Research Is 100% AI

https://www.404media.co/company-offering-100-human-written-never-ai-peer-review-is-entirely-ai/
142•Anon84•4h ago•31 comments

Grok Bot

https://x.ai/bot
236•rvz•13h ago•187 comments

Neutrinos from Deep Inside Earth Provide a New Picture of the Mantle

https://www.quantamagazine.org/neutrinos-from-deep-inside-earth-provide-a-new-picture-of-the-mant...
30•rbanffy•17h ago•2 comments

New Bedford police officer accused of using Flock cameras to track ex-partner

https://newbedfordlight.org/new-bedford-police-officer-accused-of-using-flock-cameras-to-track-an...
151•newsomix9xl•4h ago•75 comments

Making holograms with a pen plotter

https://blog.jordan.matelsky.com/Penplotter-holography/
143•DemiGuru•11h ago•14 comments

Show HN: iPhone app takes simultaneous images from 2 lenses, fuses into 1 photo

https://photosynthesis.camera
252•sajomes•3d ago•240 comments

A shell exclamation mark is not for yelling. Be lazy.

https://refp.se/articles/your-shell-and-the-lazy-exclamation-mark
7•refp•5d ago•0 comments

Show HN: Tamron Lens Utility Alternative on Linux

https://github.com/yikerman/tamron-lens-control
54•xiaoyu2006•4d ago•0 comments

Flatworms, Ion Channels, and Burning Mouths

https://www.science.org/content/blog-post/flatworms-ion-channels-and-burning-mouths
21•surprisetalk•1d ago•1 comments

Show HN: Line9 – A Mermaid rendering engine with its own layout

https://line9.ai/diagram
57•jumpalongjim•5d ago•13 comments

Go is an ideal language for AI-assisted software engineering

https://developers.googleblog.com/why-go-is-an-ideal-language-for-ai-assisted-software-engineering/
329•0xedb•13h ago•389 comments

Jolt: Clojure compiler implemented with Chez Scheme

https://jolt-lang.github.io
181•mark_l_watson•3d ago•62 comments

England set to be one of the first countries to eliminate hepatitis C

https://www.bbc.com/news/articles/c75gk620r22o
515•stevekemp•17h ago•375 comments

London Underground begins scanning passengers' faces

https://www.btp.police.uk/news/btp/news/england/btp-expands-live-facial-recognition-lfr-trial-int...
285•BlueBerry2001•20h ago•290 comments

How we used to get jobs: A newspaper classifieds story

https://ironicsans.ghost.io/how-we-used-to-get-jobs/
130•speckx•12h ago•100 comments

Manus will return to operating as an independent company

https://manus.im/blog/a-note-to-our-users
149•thm•16h ago•71 comments

CSS properties you should know for better text designs

https://master.dev/blog/typographic-css-tricks/
101•ibobev•13h ago•12 comments

pg_clickhouse v0.10: Subquery pushdown and 1000x faster TPC-H queries

https://clickhouse.com/blog/pg_clickhouse-whats-new-july-2026
52•saisrirampur•8h ago•4 comments

Emergent Introspective Awareness in Large Language Models

https://arxiv.org/abs/2601.01828
50•doener•9h ago•25 comments

Nvidia's Risky Business

https://stratechery.com/2026/nvidias-risky-business/
324•jonbaer•20h ago•157 comments