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So How Is AI Drug Discovery Doing, Really?

https://www.science.org/content/blog-post/so-how-ai-drug-discovery-doing-really
30•AnodicElegy•1h ago

Comments

EA-3167•55m ago
> "The paper goes on to make recommendations for AI companies and investigators, and these are well worth reading. The common theme is that people need to think more about why they’re doing certain techniques or using certain technologies, rather than just using them because they’re newly available."

Please. Please let some people with power and influence understand this lesson sooner rather than later. I understand the reasons that's unlikely to occur, but usually the impact isn't quite so drastic and expensive as this is. Just because something is new and shiny doesn't mean that it'll produce the outcomes you need at the other end, and until it's shown that capability your approach to it should be MODERATE.

bbondo•36m ago
Drug discovery scientists think about what they're doing and why ALL THE TIME. AI stuff is just another tool.

It's also worth mentioning that drug development timelines typically exceed the interval in which these technologies have been available (or at least effective). Measuring impact will take a long time.

Xenoamorphous•52m ago
Need one for hair loss ASAP.
asxndu•49m ago
Already exists (finasteride), only problem is that it castrates you chemicallym
pstuart•34m ago
Yep. Not everybody but enough to warrant vigilant monitoring and titration.
gradus_ad•29m ago
For everyone struggling with hair loss but concerned about side effects of Fin. Look into topical fin. It produces higher concentrations of the medication in the scalp and lower systemic concentration. Not perfect, but better.
skepticATX•29m ago
About 2% of finasteride users experience these side effects, and they are reversible after discontinuation.
pton_xd•21m ago
Apparently some users report persistent side effects even years after stopping the medication (post-finasteride syndrome).
newsomix9xl•24m ago
Indeed. My plans for a youthful Mohawk are being stymied by the lack of AI promised medical breakthroughs.

Wheres my follicles dammit?

alpineidyll3
p-o•49m ago
We're all about to come face to face with this reality. This dance can only last so long.
alpineidyll3•23m ago
if you think the state of the art in this area is something you'll hear about from a guy that looks like santa in an academic journal, your investments deserve what's about to happen to them.
GolfPopper•20m ago
>We're all about to come face to face with this reality. This dance can only last so long.

Only for values of 'all' that exclude well-connected members of the billionaire class and their select associates.

WarOnPrivacy•14m ago
nerd-fanboi proposal: Articles by national treasures (like Derek Lowe, Raymond Chen) should be highlighted with specific identifiers on HN - like a distinctive title font or an ascii diamond ◊.
snapetom•8m ago
No thanks. Social media needs less hero worship. Just RSS whoever you like.
•
24m ago
Absci has a good asset coming out pretty soon that you could try to get on the trial.

Semaglutide linked to 26% lower 5-year predicted dementia risk

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.70432
227•randycupertino•4h ago•152 comments

AI Isn't Outthinking Mathematicians. It's Out-Remembering Them

https://davidepiffer.com/p/ai-isnt-outthinking-mathematicians
224•rzk•2h ago•188 comments

AI in drug discovery — what it is, where we stand and the path forward

https://www.science.org/content/blog-post/so-how-ai-drug-discovery-doing-really
31•AnodicElegy•1h ago•16 comments

The First At-Home Test for Infected Ticks Could Improve Lyme Disease Diagnosis

https://www.smithsonianmag.com/innovation/the-first-at-home-test-for-infected-ticks-could-improve...
158•gmays•6h ago•54 comments

First human trials of designer protein therapies stun US neuroscientists

https://cen.acs.org/biological-chemistry/biotechnology/human-trial-chemogenetic-brain-therapy/104...
18•gradus_ad•1h ago•31 comments

Auto-research with codex: How I achieved a 232x Faster Kernel

https://sankalp.bearblog.dev/autoresearch/
329•tosh•9h ago•82 comments

RISC-V: They Should Have Known Better

https://dmitry.gr/?r=06.%20Thoughts&proj=12.%20RV
147•dmitrygr•1d ago•259 comments

A Spectre Is Haunting Unicode

https://www.dampfkraft.com/ghost-characters.html
101•sensanaty•5h ago•23 comments

Working with AI Feels More Like Leadership Than Coding

https://allen.bargi.org/notes/working-with-ai-feels-like-leadership/
205•allenb•9h ago•147 comments

Voltair (YC W26) Is Hiring a Test Flight Engineer

https://www.ycombinator.com/companies/voltair/jobs/sSOD2Ox-flight-test-engineer
1•wweissbluth•1h ago

Could a computer scientist build a brain?

https://stankerstjens.github.io/could-a-computer-scientist-build-a-brain/
65•ogundipeore•7h ago•38 comments

2D Gaussian Splatting for Bézier Spline Line Art Vectorization

https://studios.disneyresearch.com/2026/07/16/2d-gaussian-splatting-for-bezier-spline-line-art-ve...
43•Jimmc414•19h ago•4 comments

A controversial Alzheimer's surgery is said to reverse symptoms

https://www.nature.com/articles/d41586-026-02448-x
115•jeffreyrogers•3h ago•42 comments

BriskDB

https://github.com/schapman1974/briskdb
13•schapman1974•2h ago•4 comments

The mathematical beauty of hyperbezier curves

https://linebender.org/blog/hyperbezier/
153•raphlinus•5d ago•22 comments

Show HN: Eigendrum - Draw any shape and hear what it sounds like as a drum

https://baselashraf81.github.io/eigendrum/
157•BaselAshraf81•5d ago•83 comments

The other Sean Byrne doesn't exist

https://conic.al/writing/the-other-sean-byrne-doesnt-exist/
345•rdl•16h ago•170 comments

The Dutch Community Where People Live on Strips of Land in a Lake

https://www.core77.com/posts/144869
62•Bowes-Lyon•3h ago•34 comments

Printytron – Type it. 3D Print it

https://printytron.com
31•statenjason•6h ago•2 comments

Pizza Box Project Stack

https://cblgh.org/posts/2026-07-31-pizza-box-project-stack/
3•surprisetalk•4d ago•0 comments

Yadda 3.0.0: BDD in the Age of AI Agents

http://www.stephen-cresswell.com/2026/08/15/Yadda-3.0.0-BDD-in-the-Age-of-AI-Agents.html
46•scresswell•6h ago•24 comments

The Color of White Light

https://ludens.cl/photo/spectra/spectra.html
76•xk3•4d ago•40 comments

Using GCC's Nested Functions with Wide Pointers and No Trampolines II

https://uecker.codeberg.page/2026-07-14.html
77•uecker•12h ago•42 comments

In 1962, Egypt's Missile Program Lost Its Key Scientist Without a Trace

https://www.popularmechanics.com/military/a73358518/nazi-rocket-scientist-disappearance/
110•bookofjoe•3d ago•70 comments

Möbius Strips and Differential Equations

https://hidden-phenomena.com/articles/monodromy
52•mbustamanter•5d ago•9 comments

Qwen 3.8 27B

https://huggingface.co/Qwen/Qwen3.8-27B-FP8
1332•erdaltoprak•1d ago•759 comments

Thunderbird's Desktop Calendar Visual Redesign

https://blog.thunderbird.net/2026/08/desktop-calendar-a-design-journey/
28•birdculture•2h ago•10 comments

Robot Videos: Heavy Lift Cargo Drones, Grippers, More

https://spectrum.ieee.org/video-friday-heavy-lift-drone
7•rbanffy•5d ago•0 comments

Why tech bosses keep sharing their manifestos about AI

https://www.bbc.com/news/articles/cz97ljy91zxo
4•tcp_handshaker•56m ago•3 comments

T3X/0 a Minimal Procedural Language

https://t3x.org/t3x/0/index.html
32•AlexeyBrin•8h ago•0 comments