As with many psychoactive plants and foods, the adaptation here isn't so much a genetic/physiological tolerance as it is an often in-depth body of knowledge/practices for how to utilize the drug/medicine safely. Look at the notorious Datura for example which can cause you to go into a delirious state for over 2 days. The amount of preparation, processing, and knowledge that goes into administering it safely is lost on modern day kids who simply read an Erowid experience about a powerful psychoactive plant that likely grows locally.

Name a few. I want to be an informed person.

A reasonable person wouldn't expect honey to stop their heart though.

Yes but also we need to deal with the reality of the world, which is 1) not everyone is going to and 2) they don’t deserve to die because of it.