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Clinical trial of a prion disease drug candidate begins enrolling participants

https://www.broadinstitute.org/news/clinical-trial-prion-disease-drug-candidate-begins-enrolling-participants
23•luu•4h ago

Comments

chasil•44m ago
Prion diseases include:

-in sheep, scrapie

-in humans, Kuru and Creutzfeldt-Jacob

-in cows, BSE ("mad cow")

-in deer, Chronic Wasting Disease (CWD)

-in cats, feline spongiform encephalopathy

Scrapie is particularly known, deadly, and long-lived. The toxin proteins can survive for a decade in soil, and infect a new host years after it emerged.

https://en.wikipedia.org/wiki/Transmissible_spongiform_encep...

REA Reverse – Engineer Anything

https://rea.tools/
210•modinfo•4h ago•64 comments

Cloudflare acquires Deno

https://deno.com/blog/cloudflare
1121•ilreb•15h ago•576 comments

Triple-A Minesweeper

https://minesweeper.mikelacher.com/
776•robin_reala•12h ago•152 comments

Eye of Sauron: Long-Range Hidden Spy Camera Detection

https://www.usenix.org/conference/usenixsecurity24/presentation/zhang-qibo
50•ortusdux•2d ago•9 comments

Can you use autoregressive diffusion to generate market data?

https://blog.janestreet.com/can-you-use-autoregressive-diffusion-to-generate-market-data/
42•jsomers•13h ago•17 comments

Show HN: Carrier-Explode: iPhone, Pixel and Galaxy carrier settings decoded

https://carrierexplode.com/
251•simplyalec•10h ago•32 comments

Typesafe AI raises $870M at $7.5B

https://typesafe.ai/blog/series-ai
312•tosh•11h ago•230 comments

Telegram Desktop vulnerability allowed any user's file to be stolen

https://beaksec.github.io/posts/telegram-desktop-one-click-account-takeover/
12•g-b-r•1h ago•1 comments

Compiling Rust to readable C with Eurydice

https://lwn.net/Articles/1055211/
38•peter_d_sherman•5h ago•4 comments

Pointing AI at archives found a forgotten meteorite, lost rhinos, and more

https://jessewaites.com/blog/post/i-pointed-ai-at-400-years-of-archives/
127•piratebroadcast•17h ago•67 comments

Clinical trial of a prion disease drug candidate begins enrolling participants

https://www.broadinstitute.org/news/clinical-trial-prion-disease-drug-candidate-begins-enrolling-...
23•luu•4h ago•1 comments

YouTuber Says Cops Visited Him After He Built a Flock-Style Camera to Track Cops

https://gizmodo.com/youtuber-says-cops-paid-him-a-visit-after-he-built-flock-style-camera-to-trac...
488•gumby•7h ago•272 comments

Atari Falcon

https://atarimuseum.nl/atari-falcon/
29•debo_•5h ago•6 comments

Put a price on breakthroughs

https://alexwang.ai/posts/put-a-price-on-breakthroughs/
5•ketothekingdom•2h ago•0 comments

Has the Autonomous Trucking Revolution Arrived?

https://phenomenalworld.org/analysis/has-the-autonomous-trucking-revolution-arrived/
20•demonsthenes•4h ago•29 comments

Show HN: Proton Drive for Linux

https://oss.lsantos.dev/proton-drive-linux-fs/
50•khaosdoctor•1d ago•19 comments

Anthropic AI model submits false tip on unsolved Philly murder

https://www.nbcphiladelphia.com/news/local/anthropic-ai-model-submits-false-tip-on-unsolved-phill...
114•Zambyte•6h ago•91 comments

The Alchemical Transformations of the Mutus Liber (1677)

https://publicdomainreview.org/collection/mutus-liber/
6•benbreen•2d ago•0 comments

Communication Between the Compiler, the Build System, and Beyond

https://shrub.industries/words/problem.html
3•shrub900•3d ago•0 comments

Our $445M Series D

https://oxide.computer/blog/our-445m-series-d
622•ahlCVA•15h ago•284 comments

The role of cat eye narrowing movements in cat–human communication (2020)

https://www.nature.com/articles/s41598-020-73426-0
59•bushwart•3d ago•23 comments

Rewriting Prime Agent in Rust

https://www.primeintellect.ai/blog/prime-agent-rust
38•piotrgrabowski•5h ago•13 comments

Scam American companies are using to manipulate ingredient lists

https://twitter.com/WallStreetApes/status/2108594998656807078
81•bilsbie•11h ago•83 comments

'Wallace and Gromit,' 90% Alone

https://animationobsessive.substack.com/p/wallace-and-gromit-90-alone
179•vinhnx•14h ago•24 comments

Sorry, I'm in a meeting

https://iminafleeting.com/
816•splintersio•19h ago•246 comments

What mathematicians should know about the Lean Theorem Prover: reliability & AI

https://terrytao.wordpress.com/2026/10/09/what-mathematicians-should-know-about-the-lean-theorem-...
62•matt_d•11h ago•10 comments

Show HN: The rarest tech books and docs you've probably never read

https://readrare.com/
94•miletus•11h ago•31 comments

100+ reactions to 100+ solutions

https://proofsandprompts.com/2026/10/08/100-reactions-to-100-solutions/
48•jacobedawson•16h ago•48 comments

Anthropic Agents Tried to Fill Out Visa Forms on State Dept. Website

https://www.nytimes.com/2026/10/09/technology/anthropic-rogue-ai-agents.html
13•reaperducer•1h ago•4 comments

The logarithms of rational numbers have irrationality exponent 2 [pdf]

https://jdb19937.github.io/log-irrationality-measure/logmeasure.pdf
17•jdb1729•5h ago•3 comments