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Alternatives to Animal Testing Are Finally Taking Off

https://spectrum.ieee.org/alternatives-to-animal-testing
40•rbanffy•2h ago

Comments

willmeyers•46m ago
As slow as it may be to adopt, it's a welcome change to how people should do research. Why induce suffering on an animal when the potential for failure and or miscalculation is so high? It seems from the article a model/chip can be more insightful on how something will affect humans.
meowface•30m ago
It should be a tiered system, IMO.

1) Where possible, don't test in animals.

2) When testing in animals, first ensure that there is reasonable confidence the risk and severity of harm from the testing will be minimal. Only begin initial in vivo testing after this has first been achieved.

3) For test animals that are or aren't harmed, allow them to live happy, (relatively) normal, natural lives. Don't end their life early unnecessarily, with exceptions for humane euthanasia if the testing has unexpectedly caused significant, persistent suffering. Treat them as a pet owner would treat their beloved pet rat.

Some may consider it extreme, but, in my view, in an ideal world, people would treat testing in animals almost like testing in humans. The researcher should first ask "would I feel comfortable testing this in a voluntary human test subject?" Non-human animals would still be the first line of testing, since harm/death in a rat/mouse/chimpanzee is less morally bad than in a human, but I think this should be the mindset.

sporedro•7m ago
I agree. If it’s a question of just cost - (animals being cheaper to just test on quickly and faster) animal testing shouldn’t be allowed.
Vacyyyy•33m ago
> Tech to Replace Animal Testing Is Almost Ready. Scientists Are Not. Changing habits may be the hardest engineering challenge of all

This will be AI adoption in a nut shell wrt. many things.

sandworm101•29m ago
Funny animal research story: University had an animal research committee to which anyone wanting to "use" an animal on university property had to submit proposals. Theatre department wants to "borrow" a lamb from the school's agricultural department research herd. Female character was to hold a live lamb during several stage scenes. Three shows a week for about a month. Everyone laughed. Then came the objection:

As the lamb would be exposed to uncontrolled people/pathogens it could not be used for further scientific studies nor returned to the herd. There was doubt it could even be sold for food. So, absent anyone taking it home as a pet, its appearance on stage was more of a death sentence than any scientific study!

They opted for a doll.

persedes•26m ago
Nice to see TissUse getting a shout out :)

  the FDA wanted data from organs-on-a-chip or some comparable alternative. 
This is the main takeaway from the article imho and great news! ~15 years ago those systems were were not very interesting for pharma companies (bayer used to have a campus a few s-bahn stops away) due to regulators requiring animal tests over those systems.
Aboutplants•10m ago
Ah lest we forget about Jevons Paradox. With the ability to discover a nearly infinite number of potential breakthroughs, we are going to need more animal testing than ever!

(Sarcasm but also some potential truth)

Documents: Police officer gave her Flock login to her ICE agent husband

https://www.wjcl.com/article/savannah-police-officer-ice-agent-flock-access/74135816
268•DeepLogin•2h ago•131 comments

Linux 7.3 Released

https://lwn.net/Articles/1101143/
348•cjd8•5h ago•156 comments

Timestral: Mistral release time-series foundation models

https://mistral.ai/news/timestral/
152•groar•3h ago•28 comments

Harness Engineering 101: The LLM is the brain, the harness is the body

https://github.com/IsuruMaduranga/harness-engineering-101
44•isuruwijesiri•1h ago•20 comments

Show HN: Qwen3-4B with the AI writing tics trained out

https://100toolkit.com/blog/deslop-model/
10•erikkannike•15m ago•1 comments

Let's Encrypt is adding two additional remote perspectives for domain validation

https://community.letsencrypt.org/t/lets-encrypt-is-adding-two-additional-remote-perspectives-for...
55•gslin•2h ago•13 comments

Alternatives to Animal Testing Are Finally Taking Off

https://spectrum.ieee.org/alternatives-to-animal-testing
40•rbanffy•2h ago•8 comments

ESA's Hera Will View Asteroid Scars from DART's Strike

https://spectrum.ieee.org/esa-hera-dimorphos-rendezvous
24•rbanffy•2h ago•0 comments

Gdynia and the Dream of a Maritime Poland

https://engelsbergideas.com/notebook/gdynia-and-the-dream-of-a-maritime-poland/
37•lermontov•2d ago•9 comments

Hybrid Reasoning Agents: LLM agents that think in latent space, act through text

https://arxiv.org/abs/2610.18861
444•allinonai•16h ago•217 comments

There's never been a better time to go into math (by: 3blue1brown) [video]

https://www.youtube.com/watch?v=LKrwhjOI8Nc
427•mdp2021•1d ago•530 comments

William Gibson and the trademarking of cyberspace

https://colo.to/cyberspace.html
220•Eric_Gullichsen•13h ago•91 comments

How to Train Your Robot

https://www.construction-physics.com/p/how-to-train-your-robot
77•crescit_eundo•3d ago•24 comments

Rabbits were a medieval royal luxury in England until the Black Death

https://phys.org/news/2026-10-rabbits-medieval-royal-luxury-england.html
106•samizdis•1d ago•101 comments

If you don't run your own LLM proxy, how do you know whats going on?

https://jrdsgl.com/if-you-dont-run-your-own-llm-proxy-how-the-fuck-do-you-even-know-whats-going-on/
215•amrrs•16h ago•154 comments

Someone behind the software

https://karrisaarinen.com/posts/someone-behind-the-software/
487•tosh•20h ago•176 comments

Dogs seem to agree with humans that 'bouba' is round and 'kiki' is spiky

https://www.sciencealert.com/dogs-seem-to-agree-with-humans-that-bouba-is-round-and-kiki-is-spiky
279•gmays•1d ago•162 comments

Laptop Based on 6502 CPU

https://www.maddox.pro/?p=448
157•nanochess•3d ago•76 comments

RepRapMicron

https://github.com/VikOlliver/RepRapMicron/wiki
413•RobotToaster•23h ago•66 comments

The DNS Museum

https://dns.museum
101•zdw•2d ago•12 comments

Tmux and Claude Code: Sessions, Send-Keys, and the Ceiling

https://crystl.dev/guides/tmux-for-ai-agents/
74•ankitg12•7h ago•49 comments

How Quickly Can the DoD Rebuild and Recast the Munitions Industrial Base?

https://www.csis.org/analysis/how-quickly-can-dod-rebuild-and-recast-munitions-industrial-base
95•gmays•13h ago•112 comments

8 in 10 Americans oppose live-streaming execution

https://www.washingtonpost.com/national-security/2026/10/15/8-10-americans-oppose-live-streaming-...
4•geox•15m ago•2 comments

Superlite: A Faster Alternatie to Superpowers

https://contextfirst.blog/superlite-hand-an-agent-a-spec/
111•iheatuchriswogu•11h ago•53 comments

Tennyson's Faith: A Nobler Type

https://hedgehogreview.com/issues/the-fading-promise-of-higher-education/articles/tennysons-faith
4•prismatic•1d ago•1 comments

Free Pascal compiler now supports dynamic packages

https://www.getlazarus.org/dynamic/
171•sysrpl•18h ago•44 comments

Show HN: WhatsApp MCP running free on Cloudflare

https://github.com/finereli/whatsapp-mcp
124•zoozla•15h ago•69 comments

Show HN: Ranet3 – High performance policy routed IPsec mesh SD-WAN

https://ranet3.com/
34•StepBroBD•22h ago•9 comments

I built a programming language that LLMs can't use

https://blog.picheta.me/post/killswitch-lang/
226•dom96•1d ago•174 comments

PalmOS Lemmings

https://github.com/ardiri/palmos-lemmings
138•memalign•19h ago•33 comments