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Show HN: Checkout this open-source, local-first bioinformatics/AI desktop app

https://github.com/Liatir/liatir-app
2•Suffro•1h ago
So the basic idea behind Liatir is to have a desktop environment that works like a virtual lab for bioinformatics to do your work locally, without having to send data to a cloud service or glue together a bunch of separate tools and interfaces.

You shouldn’t need to write a single line of code to use it, but if you do know how to code, it's as extensible as you want it to be with the plugin system supporting Node, Python and Rust.

It provides regular bioinformatics tools, local scientific AI models, integrations with workflow systems such as Nextflow, API calls when you need to connect to external data or environments, scientific viewers, and visual pipelines that tie all of those pieces together.

Oh and the AI models are self-contained boxes so you do not need to set up anything and just run them.

Hope you'll find this interesting.

Show HN: A walkable 3D art history museum built from Wikipedia

https://artmuseum.artfrompixels.com/
90•jasontr•4h ago•42 comments

Show HN: Procinsh – A 3D Linux process inspector

https://github.com/akawashiro/procinsh
34•a_kawashiro•4h ago•6 comments

Show HN: Nearline, a proximity based social media

https://nearline.sxm.li/
2•saksham1341•17m ago•0 comments

Show HN: AstroHelm – Use your phone camera to aim a telescope or telephoto lens

https://astrohelm.app/
75•HeavenFox•3d ago•26 comments

Show HN: Trigora – durable execution without history replay

https://github.com/trigora-dev/trigora
4•hypervs•1h ago•0 comments

Show HN: Bigwords.page – Turn any screen into a sign. The URL is the app

https://bigwords.page/
4•SpeakingOfBrad•1h ago•1 comments

Show HN: Free calculator for US physicians' $200K-$400K student loan debt

https://www.medschooldebtcalculator.com/calculator
3•Suhinnall27•24m ago•0 comments

Show HN: See when TV shows are ready to binge

https://dvelton.github.io/binge-ready/
4•deevelton•32m ago•0 comments

Show HN: Paste-preview – see and mark up images you paste into Claude Code

https://github.com/alan890104/claude-code-paste-preview
4•alkd•45m ago•0 comments

Show HN: CrowDB – an iceberg table storage single Docker container

https://buzzcrow.github.io/blog/run-iceberg-in-one-container/
4•crowdb•57m ago•1 comments

Show HN: Configstream – Live config for Spring Boot via MongoDB change streams

https://github.com/configstream/configstream
3•reachkhajam•1h ago•0 comments

Show HN: Luke – Voice planning for coding agents

https://tryluke.dev/
4•cpan22•1h ago•2 comments

Show HN: Srl – Angular-style web components with no build step

https://github.com/BernardoGiordano/srl
3•berngiordano•1h ago•0 comments

Show HN: The Last SaaS – An open source headless SaaS for agents and assistants

https://thelastsaas.com/
3•mkly•1h ago•0 comments

Show HN: Searchable AI agents built with a JSONC DSL

https://pypi.org/project/search2o/
2•ramvenkat11•1h ago•0 comments

Show HN: In-browser STL checker for holes, non-manifold edges and bed fit

https://thespoollist.com/tools/stl-checker
2•TheSpoolList•1h ago•0 comments

Show HN: One – Post-labor biophysical resource coordination

https://github.com/kyberlex/ONE
2•kyberlex•1h ago•1 comments

Show HN: NanoMuse – An open-source AI agent for your phone and computer

https://github.com/nano-muse/nanoMuse
53•ilreb•13h ago•18 comments

Show HN: Collision avoidance in industrial robotics using robotsimulator.ai

https://www.babacad.com/robotics/web/
2•comirza•1h ago•0 comments

Show HN: Checkout this open-source, local-first bioinformatics/AI desktop app

https://github.com/Liatir/liatir-app
2•Suffro•1h ago•0 comments

Show HN: Zetteldesk – An MCP server that prints and mails letters

https://zetteldesk.com/en
2•akrost•1h ago•0 comments

Show HN: I made a TV for old cartoons

https://cartoontv.xyz/
4•a_void_sky•2h ago•1 comments

Show HN: Arcadeia – A self-hosted media library with animated video previews

https://github.com/travelonium/arcadeia
14•omidontop•2d ago•6 comments

Show HN: ProofFlick, Grammarly meets Wispr Flow for Windows, pay once

https://proofflick.com/
2•StevenFarah•2h ago•0 comments

Show HN: Pawl – Hooks that stop coding agents from deleting your home dir

https://github.com/ulukaya/pawl
2•ulukaya•2h ago•0 comments

Show HN: Chelis, a tensor language agents can write and prove

https://github.com/Chelis-Lang/chelis
3•jeffreysmith•2h ago•0 comments

Show HN: I turned my iPhone and a $20 smart plug into an f-stop timer

https://peterszentkiralyi.eu/darkplug/
83•pentakkusu•1d ago•36 comments

Show HN: Schema – Visual Git Diffs for Postgres, MySQL and SQLite Schemas

https://github.com/dobrinov/schema
3•dobrinov•4h ago•0 comments

Show HN: CloudGrip – Open-source AI proxy to cap LLM API budgets

https://github.com/Aliyunazeer/cloudgrip-backend
2•aliyunazeer07•4h ago•0 comments

Show HN: Cellula Humana – 3D interactive exploration of a human cell

https://cellulahumana.com/
7•djordjejanjic•5h ago•0 comments