https://philfung.github.io/openvaxx/

And this recent story about a man who worked with researchers to create a personalized cancer vaccine for his dog:

https://medicalxpress.com/news/2026-03-ai-cancer-vaccine-dog-oncologist.html

It got me wondering what the current technology, research, and startup landscape looks like for personalized mRNA medicine in humans.

Are any HN people working in this space, or close to it? I’m especially curious about: - how real the pipeline is today outside major institutions - which parts are getting cheaper or more accessible - which parts of the pipeline is being taken over by software and possibly new AI models - where the real bottlenecks are: sequencing, target selection, manufacturing, QC, regulation, or something else - whether anyone is building tools, infrastructure, or startups around more individualized mRNA therapies