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Integration of proteomic aging clocks in a phase 2a clinical trial

https://www.nature.com/articles/s41587-026-03286-y
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Open in hackernews

Show HN: Buckaroo – Data table UI for Notebooks

https://github.com/paddymul/buckaroo
105•paddy_m•1y ago
Buckaroo is my open source project. It is a dataframe viewer that has the basic features we expect in a modern table - scroll, search, sort. In addition there are summary stats, and histograms available. Buckaroo support Pandas and Polars dataframes and works on Jupter, Marimo, VSCode and Google Colab notebooks. All of this is extensible. I think of Buckaroo as a framework for building table UIs, and an initial data exploration app built on top of that framework. AG-Grid is used for the core table display and it has been customized with a declarative layer so you don't have to pass JS functions around for customizations. On the python side there is a framework for adding summary stats (with a small DAG for dependencies). There is also an entire Low Code UI for point and click selection of common commands (drop column). The lowcode UI also generates a python function that accomplishes the same tasks. This is built on top of JLisp - a small lisp interpreter that reads JSON flavored lisp.

Auto Cleaning looks at columns and heuristically suggests common cleaning operations. The operations are added to the lowcode UI where they can be edited. Multiple cleaning strategies can be applied and the best fit retained. Autocleaning without a UI and multiple strategies is very opaque. Since this runs heuristically (not with an LLM), it’s fast and data stays local.

I'm eager to hear feedback from data scientists and other users of dataframes/notebooks.

Comments

ZeroCool2u•1y ago
This looks really cool. I will say my default solution for this, and the default across my org, is Data Wrangler in VS Code[1]. My only wish list item is if the low code solution wrote polars instead of pandas. Any thoughts on how hard that might be to accomplish?

1: https://marketplace.visualstudio.com/items?itemName=ms-tools...

paddy_m•1y ago
Thank you.

The Buckaroo lowcode UI is capable of working with Polars, but I don't currently have any commands plumbed in. I will work on that.

I'm aware of Data Wrangler and they did nice work, but it's closed source and from what I can tell non-extensible. What features do you like in Data Wrangler, what do you wish it did differently?

paddy_m•1y ago
I made a Marimo WASM example that you can play with in your browser [1]

I need to make some updates to the polars functionality, I just completed some extensive refactorings of the Lowcode UI focussed on pandas, time to clean that up for polars too.

Also the python codegen for polars is non-idiomatic with multiple re-assignments to a dataframe, vs one big select block. I have some ideas for how to fix that, but they'll take time.

https://marimo.io/p/@paddy-mullen/notebook-sctuj8

RyanHamilton•1y ago
Congratulations on launching. Buckaroo looks great.
franky47•1y ago
But does it work across data tables with 8 dimensions?
trsohmers•1y ago
Only with the oscillation overthruster flag enabled.
hodder•1y ago
Looks cool to me. I often just end out exporting and opening in excel to do this
epistasis•1y ago
This is really great, I'm looking forward to playing with it.

Currently I use a mix of quak (preferred) and itable (if starting fom a colab notebook). It will be interesting to compare for my use cases, which most consist of checking for the distribution of data in a new file, or verifying that a transform I did resulted in the right sort of stuff.

mathisd•1y ago
How does it compare to Data Wrangler ? I like Data Wrangler because it let us open up in a separate VS Code window.