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Loss of epigenetic information as a cause of mammalian aging

https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7
1•andsoitis•5m ago•0 comments

Specsmaxxing – On overcoming AI psychosis, and why I write specs in YAML

https://acai.sh/blog/specsmaxxing
1•brendanmc6•12m ago•0 comments

The AI coding tool config problem is getting worse, not better

https://github.com/sampleXbro/agentsmesh
2•samplexBro•13m ago•0 comments

FDA Clearance of IND Application for ER-100 in Optic Neuropathies

https://www.lifebiosciences.com/life-biosciences-announces-fda-clearance-of-ind-application-for-e...
1•andsoitis•15m ago•0 comments

Show HN: Seeker – Career Routing Engine

https://www.seekerscore.com
1•danylchukllc•16m ago•1 comments

Evaluating ER-100 for Safety in People with Glaucoma or Optic Nerve Conditions

https://clinicaltrials.gov/study/NCT07290244
1•andsoitis•17m ago•0 comments

Tython – Just a Small Language

https://github.com/younissk/tython
1•modinfo•21m ago•1 comments

Artisan (YC W24) uses AI to rip off "This is Fine" artist for ad

https://bsky.app/profile/kcg.bsky.social/post/3mkwcpx45q223
1•starkparker•22m ago•0 comments

The Final Form of Software Development

https://blog.zksecurity.xyz/posts/end-coding/
1•ricochet11•23m ago•0 comments

Deep Dive into the OTel Normalizer groundcover Built for GenAI

https://www.groundcover.com/blog/otel-normalizer-genai-part-2
1•thebitofmyheart•25m ago•0 comments

MathStudio Android APK modernized for Android >= 7

https://github.com/woct0rdho/mathstudio-apk-modernized
1•woctordho•43m ago•1 comments

Unruly Play

https://www.unrulyplay.com/
3•bkudria•47m ago•0 comments

I Wrote Ultralearning. This Is What I'd Change Because of AI

https://www.scotthyoung.com/blog/2026/04/29/ultralearning-ai/
2•pullshark91•47m ago•0 comments

Show HN: UIGen – Runtime front end for any OpenAPI spec with AI skills

https://github.com/darula-hpp/uigen
3•ombedzi•48m ago•0 comments

Turning live heart rate data into a generative audio story

https://runnory.com/blog/heart-rate-writes-the-story
2•danultimateb•49m ago•1 comments

Engaging Essays in Cosmology [1971-2026]

https://archive.org/details/a.-tomilin-engaging-essays-in-cosmology-mir-titles-2026
3•the-mitr•53m ago•0 comments

Yann LeCun's Billion Dollar Bet [video]

https://www.youtube.com/watch?v=kYkIdXwW2AE
1•mfiguiere•56m ago•0 comments

Show HN: Stay Lean – Calorie Navigation

https://apps.apple.com/us/app/stay-lean-calorie-navigation/id6762153463
1•janpmz•58m ago•1 comments

Making Postman load 60% Faster

1•vedkribhu•1h ago•1 comments

Model Engines Manufacturable drawings/plans

https://outerzone.co.uk/plans.asp?cat=Engines&Xcardsperpage=48
1•pillars•1h ago•0 comments

I wrote a custom CUDA inference engine to run Qwen3.5-27B on $130 mining cards

https://news.ycombinator.com/submit
2•Haru-neo•1h ago•0 comments

Einstein's Big Idea Documentry(2005) - 1h 49M [video]

https://thinktv.pbslearningmedia.org/resource/nvfb-sci-einsteinsidea/wgbh-nova-einsteins-big-idea...
1•num42•1h ago•0 comments

Pgxbackup: Continuity Support for PgBackRest

https://thebuild.com/blog/2026/05/01/pgxbackup-continuity-support-for-pgbackrest/
1•thunderbong•1h ago•0 comments

Show HN: Keryx: TypeScript framework where one Action becomes HTTP, WS, CLI, MCP

https://www.keryxjs.com
1•evantahler•1h ago•1 comments

The Reality of Being a Man in Your 50s in South Korea

https://indignified.com/the-hidden-realities-of-midlife-masculinity-in-south-korea/
11•ZguideZ•1h ago•4 comments

Mouse Pointer as a Mere Mortal

https://unsung.aresluna.org/mouse-pointer-as-a-mere-mortal/
1•zdw•1h ago•0 comments

Quantum Machine Learning: A Pragmatic Guide for Classical ML Engineers

https://pawankjha.substack.com/p/quantum-machine-learning-the-pragmatic
2•pawanjha25•1h ago•0 comments

Redesigning Agent Skills – two missing parts

https://simianwords.bearblog.dev/what-agent-skills-misses-now/
1•simianwords•1h ago•0 comments

NodeMind – binary document index, 48× smaller than float32 RAG, no GPU required

https://github.com/QLNI/NodeMind
2•Nodemind•1h ago•0 comments

MX Script: a scripting language for one file web APIs

https://www.mxscript.com/
2•jlkdevelop•1h ago•0 comments
Open in hackernews

Show HN: Buckaroo – Data table UI for Notebooks

https://github.com/paddymul/buckaroo
105•paddy_m•11mo ago
Buckaroo is my open source project. It is a dataframe viewer that has the basic features we expect in a modern table - scroll, search, sort. In addition there are summary stats, and histograms available. Buckaroo support Pandas and Polars dataframes and works on Jupter, Marimo, VSCode and Google Colab notebooks. All of this is extensible. I think of Buckaroo as a framework for building table UIs, and an initial data exploration app built on top of that framework. AG-Grid is used for the core table display and it has been customized with a declarative layer so you don't have to pass JS functions around for customizations. On the python side there is a framework for adding summary stats (with a small DAG for dependencies). There is also an entire Low Code UI for point and click selection of common commands (drop column). The lowcode UI also generates a python function that accomplishes the same tasks. This is built on top of JLisp - a small lisp interpreter that reads JSON flavored lisp.

Auto Cleaning looks at columns and heuristically suggests common cleaning operations. The operations are added to the lowcode UI where they can be edited. Multiple cleaning strategies can be applied and the best fit retained. Autocleaning without a UI and multiple strategies is very opaque. Since this runs heuristically (not with an LLM), it’s fast and data stays local.

I'm eager to hear feedback from data scientists and other users of dataframes/notebooks.

Comments

ZeroCool2u•11mo ago
This looks really cool. I will say my default solution for this, and the default across my org, is Data Wrangler in VS Code[1]. My only wish list item is if the low code solution wrote polars instead of pandas. Any thoughts on how hard that might be to accomplish?

1: https://marketplace.visualstudio.com/items?itemName=ms-tools...

paddy_m•11mo ago
Thank you.

The Buckaroo lowcode UI is capable of working with Polars, but I don't currently have any commands plumbed in. I will work on that.

I'm aware of Data Wrangler and they did nice work, but it's closed source and from what I can tell non-extensible. What features do you like in Data Wrangler, what do you wish it did differently?

paddy_m•11mo ago
I made a Marimo WASM example that you can play with in your browser [1]

I need to make some updates to the polars functionality, I just completed some extensive refactorings of the Lowcode UI focussed on pandas, time to clean that up for polars too.

Also the python codegen for polars is non-idiomatic with multiple re-assignments to a dataframe, vs one big select block. I have some ideas for how to fix that, but they'll take time.

https://marimo.io/p/@paddy-mullen/notebook-sctuj8

RyanHamilton•11mo ago
Congratulations on launching. Buckaroo looks great.
franky47•11mo ago
But does it work across data tables with 8 dimensions?
trsohmers•11mo ago
Only with the oscillation overthruster flag enabled.
hodder•11mo ago
Looks cool to me. I often just end out exporting and opening in excel to do this
epistasis•11mo ago
This is really great, I'm looking forward to playing with it.

Currently I use a mix of quak (preferred) and itable (if starting fom a colab notebook). It will be interesting to compare for my use cases, which most consist of checking for the distribution of data in a new file, or verifying that a transform I did resulted in the right sort of stuff.

mathisd•11mo ago
How does it compare to Data Wrangler ? I like Data Wrangler because it let us open up in a separate VS Code window.