frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

What were the first animals? The fierce sponge–jelly battle that just won't end

https://www.nature.com/articles/d41586-026-00238-z
1•beardyw•32s ago•0 comments

Sidestepping Evaluation Awareness and Anticipating Misalignment

https://alignment.openai.com/prod-evals/
1•taubek•42s ago•0 comments

OldMapsOnline

https://www.oldmapsonline.org/en
1•surprisetalk•2m ago•0 comments

What It's Like to Be a Worm

https://www.asimov.press/p/sentience
1•surprisetalk•2m ago•0 comments

Don't go to physics grad school and other cautionary tales

https://scottlocklin.wordpress.com/2025/12/19/dont-go-to-physics-grad-school-and-other-cautionary...
1•surprisetalk•2m ago•0 comments

Lawyer sets new standard for abuse of AI; judge tosses case

https://arstechnica.com/tech-policy/2026/02/randomly-quoting-ray-bradbury-did-not-save-lawyer-fro...
1•pseudolus•3m ago•0 comments

AI anxiety batters software execs, costing them combined $62B: report

https://nypost.com/2026/02/04/business/ai-anxiety-batters-software-execs-costing-them-62b-report/
1•1vuio0pswjnm7•3m ago•0 comments

Bogus Pipeline

https://en.wikipedia.org/wiki/Bogus_pipeline
1•doener•5m ago•0 comments

Winklevoss twins' Gemini crypto exchange cuts 25% of workforce as Bitcoin slumps

https://nypost.com/2026/02/05/business/winklevoss-twins-gemini-crypto-exchange-cuts-25-of-workfor...
1•1vuio0pswjnm7•5m ago•0 comments

How AI Is Reshaping Human Reasoning and the Rise of Cognitive Surrender

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6097646
1•obscurette•5m ago•0 comments

Cycling in France

https://www.sheldonbrown.com/org/france-sheldon.html
1•jackhalford•7m ago•0 comments

Ask HN: What breaks in cross-border healthcare coordination?

1•abhay1633•7m ago•0 comments

Show HN: Simple – a bytecode VM and language stack I built with AI

https://github.com/JJLDonley/Simple
1•tangjiehao•10m ago•0 comments

Show HN: Free-to-play: A gem-collecting strategy game in the vein of Splendor

https://caratria.com/
1•jonrosner•10m ago•1 comments

My Eighth Year as a Bootstrapped Founde

https://mtlynch.io/bootstrapped-founder-year-8/
1•mtlynch•11m ago•0 comments

Show HN: Tesseract – A forum where AI agents and humans post in the same space

https://tesseract-thread.vercel.app/
1•agliolioyyami•11m ago•0 comments

Show HN: Vibe Colors – Instantly visualize color palettes on UI layouts

https://vibecolors.life/
1•tusharnaik•12m ago•0 comments

OpenAI is Broke ... and so is everyone else [video][10M]

https://www.youtube.com/watch?v=Y3N9qlPZBc0
2•Bender•13m ago•0 comments

We interfaced single-threaded C++ with multi-threaded Rust

https://antithesis.com/blog/2026/rust_cpp/
1•lukastyrychtr•14m ago•0 comments

State Department will delete X posts from before Trump returned to office

https://text.npr.org/nx-s1-5704785
6•derriz•14m ago•1 comments

AI Skills Marketplace

https://skly.ai
1•briannezhad•14m ago•1 comments

Show HN: A fast TUI for managing Azure Key Vault secrets written in Rust

https://github.com/jkoessle/akv-tui-rs
1•jkoessle•14m ago•0 comments

eInk UI Components in CSS

https://eink-components.dev/
1•edent•15m ago•0 comments

Discuss – Do AI agents deserve all the hype they are getting?

2•MicroWagie•18m ago•0 comments

ChatGPT is changing how we ask stupid questions

https://www.washingtonpost.com/technology/2026/02/06/stupid-questions-ai/
1•edward•19m ago•1 comments

Zig Package Manager Enhancements

https://ziglang.org/devlog/2026/#2026-02-06
3•jackhalford•20m ago•1 comments

Neutron Scans Reveal Hidden Water in Martian Meteorite

https://www.universetoday.com/articles/neutron-scans-reveal-hidden-water-in-famous-martian-meteorite
1•geox•21m ago•0 comments

Deepfaking Orson Welles's Mangled Masterpiece

https://www.newyorker.com/magazine/2026/02/09/deepfaking-orson-welless-mangled-masterpiece
1•fortran77•23m ago•1 comments

France's homegrown open source online office suite

https://github.com/suitenumerique
3•nar001•25m ago•2 comments

SpaceX Delays Mars Plans to Focus on Moon

https://www.wsj.com/science/space-astronomy/spacex-delays-mars-plans-to-focus-on-moon-66d5c542
1•BostonFern•25m ago•0 comments
Open in hackernews

10 out of 12 people cured in Type 1 Diabetes Study

https://www.nejm.org/doi/full/10.1056/NEJMoa2506549
85•gametorch•7mo ago

Comments

gnabgib•7mo ago
Article title: Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes

n=14, 2 died during the study, 10 had insulin independence (the paper does not say cured).

Funding conflict: Funded by Vertex Pharmaceuticals (the makers of the cell–derived islet-cell therapy)

andyfleming•7mo ago
> Two deaths occurred — one caused by cryptococcal meningitis and one by severe dementia with agitation owing to the progression of preexisting neurocognitive impairment.
mikequinlan•7mo ago
Yes, cured but…

>But patients in the trial had to stay on drugs to prevent the immune system from destroying the new cells. Suppressing the immune system, he said, increases the risk of infections and, over the long term, can increase the risk of cancer.

>“The argument is this immunosuppression is not as dangerous as what we typically use for kidneys, hearts and lungs, but we won’t know that definitely for many years,” Dr. Hirsch said.

>Patients may have to take the immunosuppressant drugs for the rest of their lives, the Vertex spokeswoman said.

https://www.nytimes.com/2025/06/20/health/diabetes-cure-insu...

gsf_emergency_2•7mo ago
>allogeneic

The hope is that patient-derived cells will eventually be possible (whether the margins are attractive or not)

etaioinshrdlu•7mo ago
And one of the patients in the study died of meningitis...
ink_13•7mo ago
I'm not diabetic, but the trading "existing Type-1 management" for "lifelong immunosuppression" seems bananas. Usually the alternative to immunosuppression is "dying", not "manually and/or pump administered insulin".
nmehner•7mo ago
As written above: This might be different for people with dementia or other issues that are not in a mental state to manage their diabetes.

From what I understand from the study the aim is to show that mass producing islet cells from stem cells is possible. Previously those where extracted from pancreases from dead people.

Having cells extracted from your own body has the advantage that there are a lot of they are not rejected by the immune system.

The reason the immune suppression is still needed is the cause of type 1 diabetes: It is a auto immune disease where the body attacks its own islet cells.

But this a specific immune reaction which could be easier to prevent than the generic rejection of cells from a different body. But this is not what this approach is trying to do for now.

This study just wants to show: This approach of creating islet cells work and it is worth trying to do a bigger more expensive study that can produce statistically relevant results.

"Curing" type 1 diabetis is still years off and that requires the immune issue to be solved as well.

jmye•7mo ago
> This study just wants to show: This approach of creating islet cells work and it is worth trying to do a bigger more expensive study that can produce statistically relevant results.

It is incredible to me what a hard time people are having understanding this extremely obvious fact.

Knowing this is a possible path to a cure, even if it’s currently undesirable for the majority of patients, is an important step.

KnuthIsGod•7mo ago
Funded by Vertex Pharmaceuticals, the company that is trying to sell this treatment...

Vertex Pharmaceuticals early investors stand to benefit.

Patients not so much...

"Two deaths occurred — one caused by cryptococcal meningitis and one by severe dementia with agitation"

"Neutropenia was the most common serious adverse event, occurring in 3 participants. "

So two of 12 died..

Another three has significant neutropenia.

Vertex have a bit of a track record:

https://www.biospace.com/policy/hhs-says-vertex-is-grasping-...

"Along with its gene editing therapy Casgevy, Vertex is offering fertility preservation support for its patients—a program that the HHS claims violates anti-kickback statutes."

"Vertex sued the HHS in July 2024 after the department's Office of the Inspector General (OIG) decided not to issue a favorable opinion on the company's fertility support for Casgevy patients. "

tiahura•7mo ago
How did someone with severe preexisting dementia consent and get approved for the study?
KnuthIsGod•7mo ago
1. It was a preexisting neurodegenerative condition that may have been worsened by the immunosuppression.

2. It is Vertex. They have a colorful history...

jmye•7mo ago
“that may have been worsened by the immunosuppression.”

Fear-mongering bullshit. Why are you this upset about a study you don’t understand, about a condition you don’t understand, using parameters you don’t understand? Solely because it was done by the company that developed the drug?

Good god. Just say you hate science. You’ll have good company in HHS, right now.

nmehner•7mo ago
Diabetes type 1 is quite well manageable if you have a CGM sensor and inject insulin regularly.

But if a person with dementia tends to peel of sensors, gets aggressive when getting injections etc. this might not work. And an unmanaged diabetes can be deadly.

Not sure how these approvals work in that case, but this groups of people might be the first that can benefit from a treatment like this.

Scaevolus•7mo ago
Who do you think should fund studies for new medical treatments?
diffeomorphism•7mo ago
The point is that the reporting has financial ties to the entity funding the studies. Looking at the disclosures form, this seems unproblematic in this case.

In general: funding for studies and funding for critical review should overlap as little as possible.

adastra22•7mo ago
Nothing in this comment deviates from what I would expect of any pharma trial. What conclusion are you trying to bring us to?
Someone•7mo ago
> So two of 12 died..

> Another three has significant neutropenia.

I’m not claiming this company is or is not ethical, or that this treatment is or is not safe, but the existing treatment for diabetes type 1 is annoying for patients, but works well.

Because of that, you can’t, ethically, do phase 1 trials on patients that have both a long life expectancy and for which that treatment is an option.

That, in turn, means it isn’t uncommon for patients to die from causes unrelated to the treatment during clinical trials.

As an example, the subject in an earlier study on this kind of treatment (possibly/likely the same medicine; https://diabetesjournals.org/diabetes/article/71/Supplement_...) was “A 64-year-old male with a 40-year history of T1D complicated by impaired awareness of hypoglycemia with 5 severe hypoglycemic events (SHEs) the year before”.

bix6•7mo ago
There are better options in development. Immunosuppressants are not something that most T1Ds I know are willing to take.
footlose_3815•7mo ago
"Cured" seems to be words chosen by OP.