frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

LLM Context Management: How to Improve Performance and Lower Costs

https://eval.16x.engineer/blog/llm-context-management-guide
1•paradite•16s ago•0 comments

Heritability Puzzlers

https://dynomight.net/heritable/
1•norswap•1m ago•0 comments

Show HN: Agent51 – npx agent51 get top post titles on Hacker News

https://github.com/aaurelions/agent51
1•aaurelions•4m ago•0 comments

UTCP version 1.0 is released

https://www.utcp.io/
1•juanviera23•4m ago•0 comments

Blocky Planet – Making Minecraft Spherical

https://www.bowerbyte.com/posts/blocky-planet/
1•gdevillers•6m ago•0 comments

New AI-powered live translation and language learning tools in Google Translate

https://blog.google/products/translate/language-learning-live-translate/
1•meetpateltech•6m ago•0 comments

Built an alert layer on top of QuickBooks – then Intuit added a $300/month fee

https://uselunova.com/blog/alert-layer-on-top-of-quick-books
2•chidog99•7m ago•0 comments

This House is Haunted: a decade-old RCE in the AION client

https://appsec.space/posts/aion-housing-exploit/
1•_zeta•7m ago•1 comments

No evidence ageing/declining populations compromise socio-economic performance

https://arxiv.org/abs/2508.16872
1•bikenaga•7m ago•0 comments

AI Risk Benchmark: GPT-5 Leads, but Misalignments Persist

https://substack.com/home/post/p-171928622
2•m1chael3ma•8m ago•0 comments

Beartype: Unbearably fast near-real-time type-checking in Python

https://github.com/beartype/beartype
2•ForHackernews•9m ago•0 comments

LLVM 21.1 Released with AMD GFX1250 Target, Improved RISC-V, New C/C++ Features

https://www.phoronix.com/news/LLVM-21.1-Released
1•ksec•10m ago•0 comments

Verifying drand Beacons on Ethereum

https://docs.drand.love/blog/2025/08/26/verifying-bls12-on-ethereum/
1•h0h0h0h0111•11m ago•0 comments

Spendly

https://app--spendly-e1fd5345.base44.app/
1•blxkcrift•12m ago•0 comments

Tanzlinden are German dancing trees, with the oldest from the 1680s

https://www.henrykuppen.nl/en/trees-to-make-you-happy-the-tanzlinde-of-peesten
1•speckx•13m ago•0 comments

GoDaddy gets patent for "Recommending domains from free text"

https://domainnamewire.com/2025/08/26/godaddy-gets-patent-for-recommending-domains-from-free-text/
3•us0r•13m ago•2 comments

Greenboot Rust Rewrite Approved for Fedora 43

https://www.phoronix.com/news/Greenboot-Rust-Fedora-43
1•mikece•15m ago•0 comments

First vision language model built off Open AI GPT-OSS

https://huggingface.co/OpenGVLab/InternVL3_5-GPT-OSS-20B-A4B-Preview
1•BUFU•15m ago•0 comments

Cloudflare MCP Server Portals

https://blog.cloudflare.com/zero-trust-mcp-server-portals/
1•mikece•15m ago•0 comments

See if you can break my hiding algorithm –> take the private key

https://redactsure.com/bitcoinchallenge/
1•redactsure•16m ago•1 comments

Breaking the Creepy AI in Police Cameras [video]

https://www.youtube.com/watch?v=Pp9MwZkHiMQ
2•nativeit•16m ago•0 comments

AI/ML Invisible Watermarking and Blockchain Timestamping

https://www.scoredetect.com
1•Novest•18m ago•0 comments

Building an AI Agent with LangGraph

https://spin.atomicobject.com/build-ai-agent-langgraph/
1•philk10•18m ago•0 comments

Show HN: Tweakcc – Customize Claude Code's CLI (themes, verbs, spinner)

https://github.com/Piebald-AI/tweakcc
1•bl-ue•18m ago•0 comments

Show HN: My OSS P2P file transfer tool for learning Next.js (as a C++ dev)

https://www.privydrop.app/en
1•david_bai•20m ago•0 comments

The Future Isn't Model Agnostic

https://fly.io/blog/the-future-isn-t-model-agnostic/
1•indigodaddy•20m ago•0 comments

How China Became an Innovation Powerhouse

https://www.economist.com/business/2025/08/25/how-china-became-an-innovation-powerhouse
3•bookofjoe•22m ago•2 comments

Show HN: Free Web Dialer for U.S./Canada Toll-Free Numbers (Skype Replacement?)

https://tollfree.connect-ez.com
1•Connect-EZ•24m ago•0 comments

Canadian Tech Hiring Freeze Continues

https://www.hiringlab.org/en-ca/2025/08/26/canadian-tech-hiring-freeze-continues/
2•speak_plainly•25m ago•1 comments

It's Time for Americans to Start Talking About "Soft Secession"

https://cmarmitage.substack.com/p/its-time-for-americans-to-start-talking
3•speckx•26m ago•0 comments
Open in hackernews

One Universal Antiviral to Rule Them All?

https://www.cuimc.columbia.edu/news/one-universal-antiviral-rule-them-all
71•breve•2h ago

Comments

giancarlostoro•1h ago
Wont viruses just adapt and now we've got worse viruses as a result? Isn't this kind of why doctors don't like to prescribe antibiotics too often, because they become ineffective in the long run.

I'm genuinely asking, I'm a simple software dev not a doctor.

kristjank•1h ago
Antibiotics are related to bacteria, which have different mutation mechanisms than viruses. I'm also a tech guy, so someone may correct me. Also, this seems to influence the human end to make protective material, not act on the viruses directly.
busyant•1h ago
Viruses can acquire resistance by mutation. This has been well established for decades.

FWIW, I was trained as a bacterial geneticist and routinely used bacteriophage (viruses that infect bacteria) with various resistance mutations.

Viral mutations are not restricted to viruses that infect bacteria.

edit: in fact, fundamental aspects of the genetic code were determined by analyzing and exploiting viral mutations.

https://en.wikipedia.org/wiki/Crick,_Brenner_et_al._experime...

thyristan•1h ago
Maybe, maybe not. Antibiotic resistance develops because antibiotics are only somewhat deadly to bacteria, so natural selection can occur and bacteria develop resistance over time. There are some antibiotic/bacteria combinations where this doesn't happen, because the respective antibiotic is so deadly to that special kind of bacteria, that no survivors can pass on their slightly increased resistance.

And bacteria self-replicate, whereas a virus needs to infect a cell and be reproduced by that cell. Some antiviral mechanisms attack the reproduction proteins that the human cells use, which the virus cannot do without. And the human cells don't have reproductive pressure to replicate viruses, quite the contrary.

aredox•1h ago
1) Viruses don't adapt instantly nor perfectly - that's why viruses can be animal-specific. Influenza (or recently SARS-CoV) are famous because they are malleable enough to adapt to new hosts, human or animal, within a few months or years, but not all viruses have this ability.

2) To further illustrate, some viruses have been nearly eliminated with a single vaccine. Polio didn't manage to adapt before going almost extinct. And a good reason why is:

3) Viruses can only evolve inside contaminated hosts. If you find a cure that stops quickly the virus from multiplying and contaminating, you are also curtailing its ability to adapt. A contaminated host is a giant casino machine, allowing the virus to mutate until it hits a new evolutionary step. A strong enough vaccine or treatment is like throwing out the virus before it has time to play much.

tialaramex•1h ago
Two viruses have been entirely eliminated in the wild, one (Smallpox) still exists in government research facilities the other (Rinderpest) I believe is just gone because it wasn't useful as a direct weapon (humans aren't affected) and nobody actually wants Rinderpest, it was just killing cattle and while poor farmers need their cattle or they'll starve the rich want to drink milk and eat steak so they weren't keen on this virus either and helped fund its eradication.
grapesodaaaaa•1h ago
Is it really true that we have “worse” viruses, or that they are adapting to our modern antibiotic regime & reverting to the status quo?
XorNot•1h ago
Antibiotics have never killed any viruses ever. They are exclusively for treating bacterial infections (which are generally worse by a lot).
tiahura•24m ago
Azithromycin (rhinovirus, influenza A, Zika), clarithromycin (influenza A, rhinovirus), doxycycline (dengue, Zika), minocycline (West Nile), teicoplanin/dalbavancin (Ebola, MERS/SARS-CoV and SARS-CoV-2), rifampin/rifamycins (orthopoxviruses), aminoglycosides (HSV-2, influenza A, Zika), salinomycin/monensin (influenza A/B, coronaviruses incl. SARS-CoV-2), nanchangmycin (Zika, West Nile, dengue, chikungunya), nitroxoline (mpox), and some fluoroquinolones have all shown antiviral properties.

And no, strep throat is not worse than ebola.

quotemstr•56m ago
Of course. Given unlimited time, viruses will develop resistance. Resistance = evolution = descent + modification + selection. You can quibble about whether viruses are alive, but they definitely evolve.

But so what? Anti-pathogen drugs are useful in the period during which resistance hasn't become universal, and if and when it comes a problem, we'll have other drugs.

Besides: sometimes you get lucky and the virus goes extinct before it can develop resistance (e.g. smallpox)

yablak•1h ago
Sounds like the first few scenes of every Zombie movie and TV show ever...
oaiey•27m ago
Indeed. Or an Utopia. But sentencing on that is still open
jihadjihad•20m ago
I like the turn of phrase "sentencing" here. The jury gave its verdict, guilty as all hell, and now we're ready for the sentencing hearing, Your Honor.
IIAOPSW•17m ago
There are things that are wrong and there are things that are crimes and it is up to those on the bench to appreciate the difference.
tovej•1h ago
Interesting, and potentially very good. But I can't help but wonder, like at least one other commenter, that this might have unexpected effects if applied at a larger scale. I know some viruses kill bacteria for instance. I don't know, something about universal applicability makes me a little uneasy.
XorNot•1h ago
Bacteriophages don't infect things which aren't bacteria.

In fact they're so absurdly specific that while you could bathe in a solution of them and not get sick, they also frequently fail to infect slightly different members of the same species, which is why ultimately they never become antibiotic alternatives: having the right one on hand ranges from difficult to impossible.

vprcic•1h ago
The prospect of being able to use this against viruses like the one causing rabies is pretty exciting!
account42•43m ago
Don't we already have treatments for the rabies virus but the problem is that it's too late once the virus gets to the central nervous system which is when symptoms show? How would this new antiviral be different?
abeppu•54m ago
> When he and his colleagues looked at the individuals’ immune cells, they could see encounters with all sorts of viruses—flu, measles, mumps, chickenpox. But the patients had never reported any overt signs of infection or illness.

Given that the article goes on to talk about mild persistent inflammation, is it possible that these individuals are sometimes asymptomatic but still capable of carrying/transmitting viruses at least temporarily? The article talks about potentially immunizing healthcare workers during a future pandemic, but if this was just allowing people to never develop symptoms (and not have to leave work) while having low-grade infections, would we accidentally create a work-force of Typhoid Marys?

devmor•34m ago
I am not a medical expert, but from what I read the last time I saw this being discussed, ISG15 deficiency also causes something called "infernopathy" that leads to inflammation across the entire body. I don't believe it's related to viral activity at all.
mapontosevenths•12m ago
From TFA: "We only generate a small amount of these ten proteins, for a very short time, and that leads to much less inflammation than what we see in ISG15-deficient individuals,” Bogunovic says. “But that inflammation is enough to prevent antiviral diseases."

It seems that the goal is to learn to trigger the benefits, without triggering the bad parts. Which, should probably have been obvious to you without even bothering to read the article.

quotemstr•49m ago
Broad-based inflammation delivered by lipid nanoparticle chock full of mRNA: what could possibly go wrong? I'll stick with monoclonal antibodies, thanks.

Oh, and here's what the ISG15 deficiency (the condition these mRNAs are there to simulate) does:

> Patients present...with infectious, neurologic or dermatologic features. Basal ganglia calcification is observed in all patients... The basal ganglia calcifications may cause epileptic seizures... The IFN-I inflammation may also manifest early in life as ulcerative skin lesions in the armpit, groin and neck regions. Finally, ISG15-deficiency leads to mendelian susceptibility to mycobacterial disease... [t]hese infections present as fistulizing lymphadenopathies and respiratory symptoms following BCG vaccination.

Yeah, about those antiviral superpowers...

mapontosevenths•15m ago
What's wrong with mRNA, or lipid nanoparticles?
mapontosevenths•6m ago
For the record, here are the primary researchers qualifications: https://www.pediatrics.columbia.edu/profile/dusan-bogunovic-...

His reputably published, peer reviewed, work can be found here: https://www.science.org/doi/10.1126/scitranslmed.adx5758

inka•44m ago
And the part where he says people with this mutation are more prone to bacterial infections is not worrying, because…? In a world of more and more antibiotic resistant bacteria, that does not seem like a good trade-off…