fp.

Loss of epigenetic information as a cause of mammalian aging

https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7

1•andsoitis•1m ago•0 comments

Specsmaxxing – On overcoming AI psychosis, and why I write specs in YAML

https://acai.sh/blog/specsmaxxing

1•brendanmc6•7m ago•0 comments

The AI coding tool config problem is getting worse, not better

https://github.com/sampleXbro/agentsmesh

2•samplexBro•9m ago•0 comments

FDA Clearance of IND Application for ER-100 in Optic Neuropathies

https://www.lifebiosciences.com/life-biosciences-announces-fda-clearance-of-ind-application-for-e...

1•andsoitis•11m ago•0 comments

Show HN: Seeker – Career Routing Engine

https://www.seekerscore.com

1•danylchukllc•12m ago•1 comments

Evaluating ER-100 for Safety in People with Glaucoma or Optic Nerve Conditions

https://clinicaltrials.gov/study/NCT07290244

1•andsoitis•13m ago•0 comments

Tython – Just a Small Language

https://github.com/younissk/tython

1•modinfo•17m ago•1 comments

Artisan (YC W24) uses AI to rip off "This is Fine" artist for ad

https://bsky.app/profile/kcg.bsky.social/post/3mkwcpx45q223

1•starkparker•18m ago•0 comments

The Final Form of Software Development

https://blog.zksecurity.xyz/posts/end-coding/

1•ricochet11•18m ago•0 comments

Deep Dive into the OTel Normalizer groundcover Built for GenAI

https://www.groundcover.com/blog/otel-normalizer-genai-part-2

1•thebitofmyheart•21m ago•0 comments

MathStudio Android APK modernized for Android >= 7

https://github.com/woct0rdho/mathstudio-apk-modernized

1•woctordho•39m ago•1 comments

Unruly Play

https://www.unrulyplay.com/

3•bkudria•43m ago•0 comments

I Wrote Ultralearning. This Is What I'd Change Because of AI

https://www.scotthyoung.com/blog/2026/04/29/ultralearning-ai/

2•pullshark91•43m ago•0 comments

Show HN: UIGen – Runtime front end for any OpenAPI spec with AI skills

https://github.com/darula-hpp/uigen

3•ombedzi•44m ago•0 comments

Turning live heart rate data into a generative audio story

https://runnory.com/blog/heart-rate-writes-the-story

2•danultimateb•45m ago•1 comments

Engaging Essays in Cosmology [1971-2026]

https://archive.org/details/a.-tomilin-engaging-essays-in-cosmology-mir-titles-2026

3•the-mitr•49m ago•0 comments

Yann LeCun's Billion Dollar Bet [video]

https://www.youtube.com/watch?v=kYkIdXwW2AE

1•mfiguiere•52m ago•0 comments

Show HN: Stay Lean – Calorie Navigation

https://apps.apple.com/us/app/stay-lean-calorie-navigation/id6762153463

1•janpmz•53m ago•1 comments

Making Postman load 60% Faster

1•vedkribhu•58m ago•1 comments

Model Engines Manufacturable drawings/plans

https://outerzone.co.uk/plans.asp?cat=Engines&Xcardsperpage=48

1•pillars•1h ago•0 comments

I wrote a custom CUDA inference engine to run Qwen3.5-27B on $130 mining cards

https://news.ycombinator.com/submit

2•Haru-neo•1h ago•0 comments

Einstein's Big Idea Documentry(2005) - 1h 49M [video]

https://thinktv.pbslearningmedia.org/resource/nvfb-sci-einsteinsidea/wgbh-nova-einsteins-big-idea...

1•num42•1h ago•0 comments

Pgxbackup: Continuity Support for PgBackRest

https://thebuild.com/blog/2026/05/01/pgxbackup-continuity-support-for-pgbackrest/

1•thunderbong•1h ago•0 comments

Show HN: Keryx: TypeScript framework where one Action becomes HTTP, WS, CLI, MCP

https://www.keryxjs.com

1•evantahler•1h ago•1 comments

The Reality of Being a Man in Your 50s in South Korea

https://indignified.com/the-hidden-realities-of-midlife-masculinity-in-south-korea/

10•ZguideZ•1h ago•4 comments

Mouse Pointer as a Mere Mortal

https://unsung.aresluna.org/mouse-pointer-as-a-mere-mortal/

1•zdw•1h ago•0 comments

Quantum Machine Learning: A Pragmatic Guide for Classical ML Engineers

https://pawankjha.substack.com/p/quantum-machine-learning-the-pragmatic

2•pawanjha25•1h ago•0 comments

Redesigning Agent Skills – two missing parts

https://simianwords.bearblog.dev/what-agent-skills-misses-now/

1•simianwords•1h ago•0 comments

NodeMind – binary document index, 48× smaller than float32 RAG, no GPU required

Loss of epigenetic information as a cause of mammalian aging

Specsmaxxing – On overcoming AI psychosis, and why I write specs in YAML

The AI coding tool config problem is getting worse, not better

FDA Clearance of IND Application for ER-100 in Optic Neuropathies

Show HN: Seeker – Career Routing Engine

Evaluating ER-100 for Safety in People with Glaucoma or Optic Nerve Conditions

Tython – Just a Small Language

Artisan (YC W24) uses AI to rip off "This is Fine" artist for ad

The Final Form of Software Development

Deep Dive into the OTel Normalizer groundcover Built for GenAI

MathStudio Android APK modernized for Android >= 7

Unruly Play

I Wrote Ultralearning. This Is What I'd Change Because of AI

Show HN: UIGen – Runtime front end for any OpenAPI spec with AI skills

Turning live heart rate data into a generative audio story

Engaging Essays in Cosmology [1971-2026]

Yann LeCun's Billion Dollar Bet [video]

Show HN: Stay Lean – Calorie Navigation

Making Postman load 60% Faster

Model Engines Manufacturable drawings/plans

I wrote a custom CUDA inference engine to run Qwen3.5-27B on $130 mining cards

Einstein's Big Idea Documentry(2005) - 1h 49M [video]

Pgxbackup: Continuity Support for PgBackRest

Show HN: Keryx: TypeScript framework where one Action becomes HTTP, WS, CLI, MCP

The Reality of Being a Man in Your 50s in South Korea

Mouse Pointer as a Mere Mortal

Quantum Machine Learning: A Pragmatic Guide for Classical ML Engineers

Redesigning Agent Skills – two missing parts

NodeMind – binary document index, 48× smaller than float32 RAG, no GPU required

MX Script: a scripting language for one file web APIs

MX Script: a scripting language for one file web APIs

Loss of epigenetic information as a cause of mammalian aging

Specsmaxxing – On overcoming AI psychosis, and why I write specs in YAML

The AI coding tool config problem is getting worse, not better

FDA Clearance of IND Application for ER-100 in Optic Neuropathies

Show HN: Seeker – Career Routing Engine

Evaluating ER-100 for Safety in People with Glaucoma or Optic Nerve Conditions

Tython – Just a Small Language

Artisan (YC W24) uses AI to rip off "This is Fine" artist for ad

The Final Form of Software Development

Deep Dive into the OTel Normalizer groundcover Built for GenAI

MathStudio Android APK modernized for Android >= 7

Unruly Play

I Wrote Ultralearning. This Is What I'd Change Because of AI

Show HN: UIGen – Runtime front end for any OpenAPI spec with AI skills

Turning live heart rate data into a generative audio story

Engaging Essays in Cosmology [1971-2026]

Yann LeCun's Billion Dollar Bet [video]

Show HN: Stay Lean – Calorie Navigation

Making Postman load 60% Faster

Model Engines Manufacturable drawings/plans

I wrote a custom CUDA inference engine to run Qwen3.5-27B on $130 mining cards

Einstein's Big Idea Documentry(2005) - 1h 49M [video]

Pgxbackup: Continuity Support for PgBackRest

Show HN: Keryx: TypeScript framework where one Action becomes HTTP, WS, CLI, MCP

The Reality of Being a Man in Your 50s in South Korea

Mouse Pointer as a Mere Mortal

Quantum Machine Learning: A Pragmatic Guide for Classical ML Engineers

Redesigning Agent Skills – two missing parts

NodeMind – binary document index, 48× smaller than float32 RAG, no GPU required

MX Script: a scripting language for one file web APIs