>Another egregious weakness is biology. Wolfram displays absolutely no understanding of evolution, or what would be necessary to explain the adaptation of organisms to their environments. This is related to his peculiar views on methodology. If you want to get a rough grasp of how the leopard might get its spots, then building a CA model (or something similar) can be very illuminating. It will not tell you whether that's actually how it works. This is an important example, because there is a classic theory of biological pattern formation, or morphogenesis, first formulated by Turing in the 1950s, which lends itself very easily to modeling in CAs, and with a little fine-tuning produces things which look like animal coats, butterfly wings, etc., etc. The problem is that there is absolutely no reason to think that's how those patterns actually form; no one has identified even a single pair of Turing morphogens, despite decades of searching. [See "Update, 4 March 2012" below.] Indeed, the more the biologists unravel the actual mechanisms of morphogenesis, the more complicated and inelegant (but reliable) it looks. If, however, you think you have explained why leopards are spotted after coming up with a toy model that produces spots, it will not occur to you to ask why leopards have spots but polar bears do not, which is to say that you will simply be blind to the whole problem of biological adaptation.

The deranged Wolfram story I find most delightful is about the pains he took micromanaging the illustrations in his book, and how hard he is to work for. He required a photo of a leopard, to illustrate how its spots were similar to a reaction diffusion system. But he rejected the first leopard photo and demanded it be replaced by another, because he didn't like its facial expression.

I think it's charming how aesthetically picky he was about which cat pictures to use in his book. It's not enough for the science and mathematics behind the gigantic book to be ground breaking, revolutionary, earth shattering and astounding -- but also the leopard's smirk can't give readers the wrong impression.

Speaking of Turing's "The Chemical Basis of Morphogenesis":

https://news.ycombinator.com/item?id=42519371

>Alan Turing was fascinated with morphogenesis, and wrote an article by the title "The Chemical Basis of Morphogenesis". He modeled cell growth as a reaction-diffusion systems, now known as Turing Patterns. And he was firmly against and intended to defeat the religious claptrap pseudoscience we now call "Intelligent Design". [...]

>I typed in the preface to "Morphogenesis: Collected Works of A.M. Turing", and scanned the drawing inside the front cover by Alan Turing's mother of her son watching the daisies grow:

http://donhopkins.com/home/archive/Turing/Morphogenesis.txt

http://donhopkins.com/home/AlanTuringHockeyOrWatchingTheDais...

>[...]

And note the three levels of John von Neumann's universal constructors (mechanical, mathematical, quantum):

https://news.ycombinator.com/item?id=22304084

Another criticism of this book is that it seems to give Wolfram credit for a bunch of discoveries made by a huge array of people in math, CS, and areas like complexity, game theory, artificial life and AI, etc.