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Postgres IDE in VS Code

https://techcommunity.microsoft.com/blog/adforpostgresql/announcing-a-new-ide-for-postgresql-in-vs-code-from-microsoft/4414648
326•Dowwie•3h ago•151 comments

Find Your People

https://foundersatwork.posthaven.com/find-your-people
120•jl•2h ago•48 comments

Beyond Semantics: Unreasonable Effectiveness of Reasonless Intermediate Tokens

https://arxiv.org/abs/2505.13775
49•nyrikki•2h ago•14 comments

Into The Tunnel: The secret life of wind tunnels

https://jordanwtaylor2.substack.com/p/into-the-tunnel
20•iamwil•1h ago•2 comments

Caesar's Last Breath

https://charliesabino.com/caesars-last-breath/
86•charliesabino•4h ago•38 comments

The metre originated in the French Revolution

https://www.abc.net.au/news/science/2025-05-20/metre-treaty-anniversary-metric-system-measurement-metrology/105302024
37•Tomte•3h ago•60 comments

Positional preferences, order effects, prompt sensitivity undermine AI judgments

https://www.cip.org/blog/llm-judges-are-unreliable
46•joalstein•1h ago•34 comments

Types of optical systems in a lens designer's toolbox (2020)

https://www.pencilofrays.com/lens-design-forms/
3•picture•10m ago•0 comments

You Don't Need Re-Ranking: Understanding the Superlinked Vector Layer

https://superlinked.com/vectorhub/articles/why-do-not-need-re-ranking
14•softwaredoug•1h ago•7 comments

Show HN: Samchika – A Java Library for Fast, Multithreaded File Processing

https://github.com/MayankPratap/Samchika
40•mprataps•5h ago•24 comments

Sesame Scheme: Unintended Consequences of Allergen Food Labeling

https://www.choicesmagazine.org/choices-magazine/submitted-articles/unintended-consequences-of-allergen-food-labeling
16•hilux•1h ago•3 comments

Why I no longer have an old-school cert on my HTTPS site

https://rachelbythebay.com/w/2025/05/22/ssl/
141•mcbain•7h ago•121 comments

Designing type inference for high quality type errors

https://blog.polybdenum.com/2025/02/14/designing-type-inference-for-high-quality-type-errors.html
36•PaulHoule•4d ago•6 comments

Remembering Alasdair MacIntyre

https://www.wordonfire.org/articles/remembering-alasdair-macintyre-1929-2025/
101•danielam•7h ago•41 comments

MCP is the coming of Web 2.0 2.0

https://www.anildash.com//2025/05/20/mcp-web20-20/
94•freediver•3h ago•88 comments

Writing A Job Runner (In Elixir) (Again) (10 years later)

https://github.com/notactuallytreyanastasio/genstage_tutorial_2025/blob/main/README.md
90•rhgraysonii•8h ago•24 comments

Slime (2021)

https://granta.com/slime/
15•Tomte•2h ago•0 comments

The Curious Case of the Pygmy Nuthatch

https://slate.com/culture/2025/05/birds-movies-charlies-angels-2000-pygmy-nuthatch.html
105•prawn•2d ago•14 comments

John Carmack talk at Upper Bound 2025

https://twitter.com/ID_AA_Carmack/status/1925710474366034326
399•tosh•13h ago•260 comments

How to live on $432 a month in America

https://shagbark.substack.com/p/how-to-live-on-432-a-month-in-america
24•cactusplant7374•2h ago•10 comments

Tallest Wooden Wind Turbine

https://modvion.com/
145•Bluestein•4d ago•105 comments

Satellites Spotting Depth

https://tech.marksblogg.com/depth-anything-v2-maxar-ai-detection.html
82•marklit•2d ago•21 comments

'Turbocharged' Mitochondria Power Birds' Epic Migratory Journeys

https://www.quantamagazine.org/turbocharged-mitochondria-power-birds-epic-migratory-journeys-20250519/
69•pseudolus•4d ago•16 comments

Alberta separatism push roils Canada

https://www.nytimes.com/2025/05/22/world/canada/alberta-separatism-referendum.html
6•paulpauper•1h ago•16 comments

Bits with Soul

https://www.darwin.cam.ac.uk/lectures/entry/bits-with-soul/
24•mrkeen•4d ago•5 comments

Show HN: Defuddle, an HTML-to-Markdown alternative to Readability

https://github.com/kepano/defuddle
365•kepano•21h ago•61 comments

Sugar-Coated Poison: Benign Generation Unlocks LLM Jailbreaking

https://arxiv.org/abs/2504.05652
40•favoboa•2d ago•35 comments

Measuring Lunar North and South Polar Regions

https://iopscience.iop.org/article/10.3847/PSJ/adbc9d
7•bryanrasmussen•4d ago•2 comments

KumoRFM: A Foundation Model for In-Context Learning on Relational Data

https://kumo.ai/company/news/kumo-relational-foundation-model/
97•cliffly•11h ago•17 comments

Quantum Picturalism

https://quantuminpictures.org/
48•mathgenius•2d ago•16 comments
Open in hackernews

'Turbocharged' Mitochondria Power Birds' Epic Migratory Journeys

https://www.quantamagazine.org/turbocharged-mitochondria-power-birds-epic-migratory-journeys-20250519/
69•pseudolus•4d ago

Comments

coolcase•8h ago
Wouldn't mind some bird mitochondria!
b800h•8h ago
Seriously, what would happen if we swapped out human mitochondria from a zygote for bird mitochondria?
jyounker•8h ago
I don't think you'd get the same sort of effects, because a huge part of the mitochondrial regulation and function is carried out by genes and gene products from outside the mitochondria.

It would be an interesting experiment though. I'd expect that they might not live, or that the cell would function sub-optimally, but who knows, maybe the cellular machinery is highly conserved.

dejj•7h ago
Yes. Afaik from Nick Lane’s “Oxygen” the Cytochrome Oxidase made from the mitochondrial DNA have to match the Cytochrome C made from nuclear DNA. Even slight mismatch seems to lower mitochondrial performance and is a problem why heteroplasmy (mixing of mitochondria from father and mother) seems to be selected-out.
treyd•3h ago
Well what if you also swapped out those genes?
dghughes•3h ago
You'd get Kids in the Hall Chicken Lady.
mckirk•3h ago
And some whale blood!
ljf•8h ago
Previously posted: https://news.ycombinator.com/item?id=44051652 (1 day ago, 78 comments)
rbanffy•2h ago
Can the entries be merged?
EGreg•2h ago
Can they? Yes. Should they? No.
rbanffy•2h ago
Why have two separate discussions on the same topic a day apart?
gherkinnn•8h ago
No layman's discussion about mitochondria is complete without the In Our Time episode on just that:

https://www.bbc.co.uk/programmes/m001md34

It is one of my favourites.

londons_explore•7h ago
What is the typical lifespan of ATP within a cell?

Are we talking milliseconds or minutes?

pfdietz•6h ago
According to the wikipedia page on ATP, the average ATP concentration in eukaryotic cells is 1 to 10 micromols per gram.

According to https://bionumbers.hms.harvard.edu/bionumber.aspx?s=n&v=2&id... a single mammalian cell has a mass of 3 to 4 nanograms.

Google AI tells me the average rate of ATP formation in a mammalian cell is around 10 million molecules per second.

The ratio here ranges from 3 to 40 minutes.

I imagine it varies greatly depending on cell type.

eitally•5h ago
From an exercise physiology point of view, it's generally accepted that ATP-CP powered motility is possible for only about 10 seconds (that is to say, you only store enough ATP for about 10 seconds of high intensity work -- sprinting, maximal weight lifting, etc). After that, other energy systems become dominant ... both of which create ATP but depend on either glycolysis (anaerobic) or oxidative phosphorylation (aerobic) for the process/conversion.
ck2•3h ago
vaguely related there is a fantastic new PBS Space Time this week which suggests the "no alien life" fermi paradox may be related to how our mitochondria evolved by a series of fortunate accidents which may not be reproducible elsewhere

https://www.pbs.org/video/is-there-a-simple-solution-to-the-...

( https://www.youtube.com/watch?v=abvzkSJEhKk )