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A Visual Guide to Genome Editors

https://www.asimov.press/p/a-visual-guide-to-genome-editors

40•surprisetalk•2d ago

Comments

chriscrisby•5h ago

I honestly thought it was Gnome editors.

obloid•54m ago

I also misread it as Gnome editors and was briefly very confused when I started reading the article.

liotier•3h ago

I naïvely expected some sort of IDE, and jokingly thought about compilation spitting out a vial of CRISPR & payload for the desired sequence... The instantaneïty of computer programming has seriously warped our expectations.

Curved-Crease Sculpture

https://erikdemaine.org/curved/

118•wonger_•5h ago•16 comments

Andrej Karpathy: Software in the era of AI [video]

https://www.youtube.com/watch?v=LCEmiRjPEtQ

961•sandslash•19h ago•545 comments

How OpenElections uses LLMs

https://thescoop.org/archives/2025/06/09/how-openelections-uses-llms/index.html

39•m-hodges•3h ago•6 comments

Show HN: A DOS-like hobby OS written in Rust and x86 assembly

https://github.com/krustowski/rou2exOS

100•krustowski•6h ago•11 comments

Star Quakes and Monster Shock Waves

https://www.caltech.edu/about/news/star-quakes-and-monster-shock-waves

13•gmays•2d ago•0 comments

Compiling LLMs into a MegaKernel: A Path to Low-Latency Inference

https://zhihaojia.medium.com/compiling-llms-into-a-megakernel-a-path-to-low-latency-inference-cf7840913c17

3•matt_d•25m ago•0 comments

Homegrown Closures for Uxn

https://krzysckh.org/b/Homegrown-closures-for-uxn.html

17•todsacerdoti•2h ago•0 comments

Show HN: EnrichMCP – A Python ORM for Agents

https://github.com/featureform/enrichmcp

33•bloppe•2h ago•8 comments

We Can Just Measure Things

https://lucumr.pocoo.org/2025/6/17/measuring/

29•tosh•2d ago•22 comments

Posit floating point numbers: thin triangles and other tricks (2019)

http://marc-b-reynolds.github.io/math/2019/02/06/Posit1.html

36•fanf2•5h ago•15 comments

Show HN: Claude Code Usage Monitor – real-time tracker to dodge usage cut-offs

https://github.com/Maciek-roboblog/Claude-Code-Usage-Monitor

152•Maciej-roboblog•9h ago•93 comments

Juneteenth in Photos

https://texashighways.com/travel-news/the-history-of-juneteenth-in-photos/

92•ohjeez•2h ago•37 comments

Flowspace (YC S17) Is Hiring Software Engineers

https://flowspace.applytojob.com/apply/6oDtY2q6E9/Software-Engineer-II

1•mrjasonh•2h ago

Guess I'm a Rationalist Now

https://scottaaronson.blog/?p=8908

146•nsoonhui•9h ago•421 comments

Show HN: Unregistry – “docker push” directly to servers without a registry

https://github.com/psviderski/unregistry

582•psviderski•20h ago•128 comments

Geochronology supports LGM age for human tracks at White Sands, New Mexico

https://www.science.org/doi/10.1126/sciadv.adv4951

23•gametorch•4h ago•8 comments

Public/protected/private is an unnecessary feature

https://catern.com/private.html

27•PaulHoule•2d ago•20 comments

Researchers are now vacuuming DNA from the air

https://www.sciencedaily.com/releases/2025/06/250603114822.htm

44•karlperera•3d ago•38 comments

From LLM to AI Agent: What's the Real Journey Behind AI System Development?

https://www.codelink.io/blog/post/ai-system-development-llm-rag-ai-workflow-agent

97•codelink•10h ago•31 comments

What would a Kubernetes 2.0 look like

https://matduggan.com/what-would-a-kubernetes-2-0-look-like/

73•Bogdanp•7h ago•112 comments

Why do we need DNSSEC?

https://howdnssec.works/why-do-we-need-dnssec/

32•gpi•2h ago•55 comments

Show HN: TrendFi – I built AI trading signals that self-optimize

https://trend.fi

22•wolfman1•3d ago•25 comments

Visual History of the Latin Alphabet

https://uclab.fh-potsdam.de/arete/en

77•speckx•2d ago•53 comments

Munich from a Hamburger's perspective

https://mertbulan.com/2025/06/14/munich-from-a-hamburgers-perspective/

82•toomuchtodo•3d ago•57 comments

Getting Started Strudel

https://strudel.cc/workshop/getting-started/

106•rcarmo•3d ago•43 comments

The Scheme That Broke the Texas Lottery

https://www.newyorker.com/news/letter-from-the-southwest/the-scheme-that-broke-the-texas-lottery

29•mitchbob•6h ago•14 comments

Elliptic Curves as Art

https://elliptic-curves.art/

179•nill0•15h ago•24 comments

Finding Dead Websites

https://www.marginalia.nu/log/a_122_dead_websites/

87•ingve•2d ago•15 comments

My iPhone 8 Refuses to Die: Now It's a Solar-Powered Vision OCR Server

https://terminalbytes.com/iphone-8-solar-powered-vision-ocr-server/

410•hemant6488•1d ago•168 comments

In praise of "normal" engineers

https://charity.wtf/2025/06/19/in-praise-of-normal-engineers/

95•zdw•2h ago•68 comments