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OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
576•klaussilveira•10h ago•167 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
888•xnx•16h ago•540 comments

How we made geo joins 400× faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
90•matheusalmeida•1d ago•20 comments

What Is Ruliology?

https://writings.stephenwolfram.com/2026/01/what-is-ruliology/
18•helloplanets•4d ago•9 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
20•videotopia•3d ago•0 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
197•isitcontent•11h ago•24 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
199•dmpetrov•11h ago•90 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
307•vecti•13h ago•136 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
352•aktau•17h ago•175 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
350•ostacke•17h ago•91 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
452•todsacerdoti•18h ago•228 comments

Delimited Continuations vs. Lwt for Threads

https://mirageos.org/blog/delimcc-vs-lwt
20•romes•4d ago•2 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
78•quibono•4d ago•17 comments

PC Floppy Copy Protection: Vault Prolok

https://martypc.blogspot.com/2024/09/pc-floppy-copy-protection-vault-prolok.html
52•kmm•4d ago•3 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
253•eljojo•13h ago•152 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
388•lstoll•17h ago•263 comments

Was Benoit Mandelbrot a hedgehog or a fox?

https://arxiv.org/abs/2602.01122
5•bikenaga•3d ago•1 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
230•i5heu•13h ago•174 comments

Zlob.h 100% POSIX and glibc compatible globbing lib that is faste and better

https://github.com/dmtrKovalenko/zlob
12•neogoose•3h ago•7 comments

Female Asian Elephant Calf Born at the Smithsonian National Zoo

https://www.si.edu/newsdesk/releases/female-asian-elephant-calf-born-smithsonians-national-zoo-an...
24•gmays•6h ago•5 comments

Show HN: R3forth, a ColorForth-inspired language with a tiny VM

https://github.com/phreda4/r3
68•phreda4•10h ago•12 comments

Why I Joined OpenAI

https://www.brendangregg.com/blog/2026-02-07/why-i-joined-openai.html
116•SerCe•7h ago•94 comments

I spent 5 years in DevOps – Solutions engineering gave me what I was missing

https://infisical.com/blog/devops-to-solutions-engineering
135•vmatsiiako•16h ago•59 comments

Understanding Neural Network, Visually

https://visualrambling.space/neural-network/
268•surprisetalk•3d ago•36 comments

Introducing the Developer Knowledge API and MCP Server

https://developers.googleblog.com/introducing-the-developer-knowledge-api-and-mcp-server/
42•gfortaine•8h ago•13 comments

Learning from context is harder than we thought

https://hy.tencent.com/research/100025?langVersion=en
168•limoce•3d ago•87 comments

I now assume that all ads on Apple news are scams

https://kirkville.com/i-now-assume-that-all-ads-on-apple-news-are-scams/
1039•cdrnsf•20h ago•431 comments

FORTH? Really!?

https://rescrv.net/w/2026/02/06/associative
60•rescrv•18h ago•22 comments

Show HN: ARM64 Android Dev Kit

https://github.com/denuoweb/ARM64-ADK
14•denuoweb•1d ago•2 comments

Show HN: Smooth CLI – Token-efficient browser for AI agents

https://docs.smooth.sh/cli/overview
88•antves•1d ago•63 comments
Open in hackernews

Psilocybin treatment extends cellular lifespan, improves survival of aged mice

https://www.nature.com/articles/s41514-025-00244-x
47•pseudolus•7mo ago

Comments

redwood•7mo ago
What a wild coincidence if true. Unless somehow the psychoactive effects are caused by the same thing... and how wild that would be considering the effect of the drug is to put you back into the state of in-the-moment wonder as if a child again!
joshuamcginnis•7mo ago
Exercise, healthy diet, caloric restriction, adequate sleep, and stress management have also all had been shown to extend cellular lifespan and improve survival of aged mice - and humans.
purrplexed•7mo ago
Adding another thing to that list can't be bad can it?
oulu2006•7mo ago
Exactly, keep adding to it - and they all add up.
gcp123•7mo ago
Having spent some time working on aging research before transitioning to biotech, this paper genuinely excited me in a way that few studies have recently. The longevity field is littered with compounds that work beautifully in vitro but fail spectacularly in vivo - seeing psilocybin deliver both cellular lifespan extension AND improved survival in aged mice is remarkable.

What strikes me most is the mechanistic plausibility. The SIRT1 upregulation, reduced oxidative stress, and telomere preservation they observed align perfectly with what we know about successful aging interventions. When I was working on senescence research, we’d get compounds that would extend cellular lifespan by targeting one pathway, but they’d often have off-target effects that negated benefits in whole organisms.

The dosing strategy here is particularly clever - starting with 5mg/kg for acclimation, then monthly 15mg/kg treatments. That mirrors what we’re seeing in clinical trials for depression, but applied to aging. I remember being skeptical when colleagues first suggested psychedelics might have systemic anti-aging effects beyond their neurological benefits, but the serotonin receptor distribution throughout the body makes this increasingly plausible.

The survival curve (80% vs 50%) is the kind of effect size that gets my attention. In aging research, we’re usually thrilled with 10-20% lifespan extension. But starting treatment at 19 months (equivalent to 60-65 human years) makes this especially compelling - most aging interventions need to start early in life to be effective.

My main concern is the limited exploration of potential downsides. Delayed senescence can be a double-edged sword - those cells that keep proliferating longer might accumulate DNA damage that wasn’t detected in their short-term assays. We need much longer studies to understand cancer risk.

Still, given psilocybin’s remarkable safety profile and the FDA’s breakthrough therapy designation, this opens fascinating possibilities for combining psychedelic therapy with longevity medicine. Imagine treating both the psychological burden of aging and its biological mechanisms simultaneously.

oulu2006•7mo ago
love this comment - i read this as well and was excited to see it on hackernews
dinfinity•7mo ago
> The dosing strategy here is particularly clever - starting with 5mg/kg for acclimation, then monthly 15mg/kg treatments. That mirrors what we’re seeing in clinical trials for depression, but applied to aging.

15mg/kg seems like a lot, though. 15mg per person is a 'common' dose for a human. I don't know what the mapping between mice and humans is, but tripping on 1500mg of psilocybin once a month would be pretty taxing for me.

Projectiboga•7mo ago
One catch is both of those dosing levels are relatively large. This isn't toxic in the classic sense, but those are both heroic dosages on the mental effects side. I think this is like 20-80 grams of dried shrooms.
akhosravian•7mo ago
These dosages are off the charts for what most people ever do.

A typical estimate is 15 mg psilocybin per gram of dried mushroom so for a 200 pound person that’s 90 grams of mushrooms. 5 grams is the classic heroic dose.

southernplaces7•7mo ago
One sees many of these kinds of papers about X or Y doing this or that incredible feat of life extension in mice. The problem is that aside from many of these papers possibly having some dubious methodology, the subjects are mice. That's some seriously different physiology and a whole pile of other biological differences, right down to the genetic level. Seems obvious, but many news stories about it seem to gloss over just how far a medical advance in mice is from anything resembling useful technology for humans.

Hell, if we could apply to humans all the therapies and treatments that have so far cured or at least helped with cancer, Parkinsons, dementia and aging itself in mice and rats, among other things, we'd long since have created a much easier time with these diseases.

Euphorbium•7mo ago
I did tons of mushrooms in my twenties and mosr people estimate my age in my twenties. I am 35.