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The Art of Multiprocessor Programming 2nd Edition Book Club

https://eatonphil.com/2025-art-of-multiprocessor-programming.html
68•eatonphil•1h ago•9 comments

Compressing Icelandic name declension patterns into a 3.27 kB trie

https://alexharri.com/blog/icelandic-name-declension-trie
132•alexharri•4h ago•41 comments

We may not like what we become if A.I. solves loneliness

https://www.newyorker.com/magazine/2025/07/21/ai-is-about-to-solve-loneliness-thats-a-problem
143•defo10•4h ago•206 comments

WebGPU enables local LLM in the browser. Demo site with AI chat

https://andreinwald.github.io/browser-llm/
21•andreinwald•1h ago•5 comments

Unikernel Guide: Build and Deploy Lightweight, Secure Apps

https://tallysolutions.com/technology/introduction-to-unikernel-2/
16•Bogdanp•1h ago•1 comments

6 Weeks of Claude Code

https://blog.puzzmo.com/posts/2025/07/30/six-weeks-of-claude-code/
70•mpweiher•3h ago•31 comments

The case for having roommates (even when you can afford to live alone)

https://supernuclear.substack.com/p/the-case-for-having-roommates-even
20•surprisetalk•1h ago•31 comments

The Rubik's Cube Perfect Scramble

https://www.solutionslookingforproblems.com/post/the-rubik-s-cube-perfect-scramble
16•notagoodidea•1h ago•3 comments

Ana Marie Cox on the Shaky Foundation of Substack as a Business

https://newsletter.anamariecox.com/archive/substack-did-not-see-that-coming/
4•Bogdanp•25m ago•1 comments

Caches: LRU vs. Random

https://danluu.com/2choices-eviction/
42•gslin•2d ago•6 comments

Microsoft is open sourcing Windows 11's UI framework

https://www.neowin.net/news/microsoft-is-taking-steps-to-open-sourcing-windows-11-user-interface-framework/
91•bundie•7h ago•88 comments

Cerebras Code

https://www.cerebras.ai/blog/introducing-cerebras-code
406•d3vr•17h ago•156 comments

ThinkPad designer David Hill spills secrets, designs that never made it

https://www.theregister.com/2025/08/02/thinkpad_david_hill_interview/
61•LorenDB•3h ago•8 comments

Financial Lessons from My Family's Experience with Long-Term Care Insurance

https://www.whitecoatinvestor.com/financial-lessons-father-long-term-care-insurance/
5•wallflower•1h ago•1 comments

Coffeematic PC – A coffee maker computer that pumps hot coffee to the CPU

https://www.dougmacdowell.com/coffeematic-pc.html
251•dougdude3339•17h ago•76 comments

Aerodynamic drag in small cyclist formations: shielding the protected rider [pdf]

http://www.urbanphysics.net/2025_Formation_Paper_Preprint_v1.pdf
44•PaulHoule•3d ago•14 comments

Go's race detector has a mutex blind spot

https://doublefree.dev/go-race-mutex-blindspot/
7•susam•2d ago•0 comments

OpenAI's "Study Mode" and the risks of flattery

https://resobscura.substack.com/p/openais-new-study-mode-and-the-risks
77•benbreen•2d ago•67 comments

Why leather is best motorcycle protection [video]

https://www.youtube.com/watch?v=xwuRUcAGIEU
136•lifeisstillgood•2d ago•110 comments

At 17, Hannah Cairo solved a major math mystery

https://www.quantamagazine.org/at-17-hannah-cairo-solved-a-major-math-mystery-20250801/
404•baruchel•23h ago•163 comments

This Month in Ladybird

https://ladybird.org/newsletter/2025-07-31/
334•net01•9h ago•105 comments

Palo Alto Networks closing on over $20B acquisition of CyberArk

https://www.calcalistech.com/ctechnews/article/hksugkiwxe
8•tomashertus•3d ago•0 comments

JavaScript retro sound effects generator

https://github.grumdrig.com/jsfxr/
119•selvan•4d ago•21 comments

Weather Model based on ADS-B

https://obrhubr.org/adsb-weather-model
224•surprisetalk•3d ago•35 comments

Cadence Guilty, Pays $140M for Exporting Semi Design Tools to PRC Military Uni

https://www.justice.gov/opa/pr/cadence-design-systems-agrees-plead-guilty-and-pay-over-140-million-unlawfully-exporting
25•737min•2h ago•12 comments

I couldn't submit a PR, so I got hired and fixed it myself

https://www.skeptrune.com/posts/doing-the-little-things/
300•skeptrune•22h ago•184 comments

Hardening mode for the compiler

https://discourse.llvm.org/t/rfc-hardening-mode-for-the-compiler/87660
141•vitaut•13h ago•44 comments

Yearly Organiser

https://neatnik.net/calendar/
86•anewhnaccount2•4d ago•23 comments

Palo Alto Networks agrees to buy CyberArk for $25B

https://techcrunch.com/2025/07/30/palo-alto-networks-agrees-to-buy-cyberark-for-25-billion/
50•vmatsiiako•2d ago•40 comments

Ask HN: Who is hiring? (August 2025)

211•whoishiring•1d ago•239 comments
Open in hackernews

New research finds that ivermectin could help control malaria transmission

https://www.ndm.ox.ac.uk/news/new-research-supports-ivermectin-as-an-effective-strategy-to-control-malaria-transmission
40•rguiscard•3h ago

Comments

kacesensitive•2h ago
Ivermectin has a surprisingly interesting origin, it was discovered in soil near a Japanese golf course and developed from a bacterium that kills parasites. It went on to treat diseases like river blindness and became widely used in both human and veterinary medicine. Despite all that, it’s definitely not some miracle drug or cure-all like some would have you believe. Though that didn’t stop my grandpa from stockpiling it after watching too many Fox News ads.
andy_ppp•2h ago
Yes, I really am always shocked by the Joe Rogans et. al. who spout off about random fad pharmaceuticals like this (with microscopic grains of truth that’s been twisted), they don’t even understand the basics of what is done to prove anything at all works effectively but in complete stupidity there’s a certainty I don’t think I have about anything.

People are more likely to believe Mel Gibson than a scientist on this stuff, it’s going to lead to absolute disaster.

ttoinou•2h ago
Of course but the real question is how good the competition / alternative to Joe Rogan is. If he replaces MSM (all their lies and manipulation), then he’s better, even if he has low proof for what he talks about
kytazo•2h ago
Why was this flagged?
kibwen•2h ago
I didn't flag it, but possibly because it pretends that Joe Rogan doesn't count as "mainstream media" despite being extremely mainstream, or alternatively because it pretends that "mainstream media" is somehow inherently untrustworthy in a way that Joe Rogan is immune to despite his acknowledged detachment from reality.
ttoinou•1h ago
New medias grow and become mainstream yes. You have to interpret each word in when they happened chronologically…
felixgallo•2h ago
The false narrative that there's a 'mainstream media' which is lies and propaganda, as compared to plucky unafraid truth-telling upstarts like Fox and Sinclair and Joe Rogan.
kennywinker•2h ago
Might makes right?

Success in a media marketplace is not the same as quality, honesty, or integrity.

ImHereToVote•2h ago
I believe it was a licensed MD who prescribed Ivermectin to him. It might be that we all have some parasites that worsen COVID immune reactions.
bamboozled•2h ago
Yet there was zero evidence to suggest it would work for COVID, and people like him going around saying it worked, or they had "good results", based on nothing. Then they caused a shortage of the drug in places it was needed. So he actually caused harm with his BS.

I also got a fairly early strain of COVID and didn't have Ivermectin and I got over it pretty easily too? I just thought I pushed it too hard in the gym and felt a bit tired. My cousin got it, ended up in hospital on Oxygen.

Joe Rogan is just a fool and a propagandist.

zoklet-enjoyer•43m ago
iirc, this is what caused the hype with ivermectin. I went to Fleet Farm and bought several tubes as soon as I read this. Because why not? By the time the Joe Rogan types started talking about it, my stash was already expired. I've periodically taken it when I've been exposed to bed bugs and fleas. And as a preventative thing when I'm going into areas with a lot of ticks. The apple flavored horse paste is nasty.

https://www.sciencedirect.com/science/article/pii/S016635422...

smallerfish•2h ago
Yes, and there are licensed MDs working for RFK specifically to demonize vaccines (while there are many other licensed MDs who see vaccines as being very positive and efficacious). A license doesn't make you right.
ImHereToVote•2h ago
I would rather trust an MD over a rando on the Internet sorry.
kennywinker•2h ago
Which licensed MD?

If there are 100 licensed MDs telling you it’s BS, and 1 telling you it’s a miracle cure…

wat10000•1h ago
What do you call someone who graduates last in their class in medical school?

“Doctor.”

There’s no shortage of credentialed quacks out there.

ujkhsjkdhf234•38m ago
Get involved in sports and you'll learn you can find a crooked doctor to prescribe anything and I mean ANYTHING.
danans•1h ago
> Yes, I really am always shocked by the Joe Rogans et. al. who spout off about random fad pharmaceuticals like this

Why shocked?

It seems quite normal since we live in an age where there is no accountability for spouting that stuff, and probably a major economic upside for the person spouting it.

Snake oil has never had a bigger market than it has today, aided by the Internet as a platform.

bamboozled•2h ago
Golf is awesome...I know that much for sure.
gus_massa•2h ago
> it’s definitely not some miracle drug or cure-all like some would have you believe

I agree. Anyway, there is a nice post about Ivermectin in 2020 by Derek Lowe (In the Pipeline) https://www.science.org/content/blog-post/what-s-ivermectin the most relevant quotes are:

> The drug is effective against a wide number of parasites and arthropods in general

> Its ion-channel mechanism of action against parasites has no application to viruses.

cryptoegorophy•1h ago
It would’ve been very nice to show early in Covid the scale size of parasites vs viruses. Calling it a horse dewormer created the opposite, conspiracy effect.
sjsdaiuasgdia•58m ago
"Well if it can kill that big ol' thing, surely it can absolutely destroy those microscopic bastards!"

A whole lot of people will ignore or rationalize away evidence that disagrees with what they have already decided is true.

rolph•45m ago
it really is gloomy to see one who now realizes how mistaken it is, and have to help them through the aftermath.
vnchr•2h ago
The discoverers of ivermectin shared a Nobel Prize in 2015 [0] with a discoverer of a novel malaria treatment. Interesting coincidence.

[0] https://www.nobelprize.org/prizes/medicine/2015/press-releas...

walterbell•2h ago
https://www.medpagetoday.com/special-reports/features/116436

> Four states -- Tennessee, Arkansas, Idaho, and Louisiana -- have passed OTC ivermectin laws

> [Nine] other states have bills moving through their legislatures

zoklet-enjoyer•42m ago
You can just go buy it at any farm supply store. Same thing with DMSO
walterbell•19m ago
State legislative processes have multiple functions.
amluto•1h ago
> It has now been shown to reduce malaria transmission by killing the mosquitoes that feed on treated individuals.

That seems like it will interfere with careless randomized controlled trial design. If the drug kills mosquitos, it could easily do less well at preventing the user from getting infected by a mosquito, but it could potentially prevent an infected patient from spreading an infection via mosquito or even kill a mosquito that would otherwise subsequently spread an infection between two other people.

In any case, here’s a better article. It seems the authors are very much aware of this issue, and they randomized entire clusters of people:

https://www.science.org/content/article/well-known-drug-coul...

OutOfHere•1h ago
This paper seems misleading to me because ivermectin was dosed only once a month at about a standard dose. Based on the drug's pharmacology, there is no way in which it could maintain any effectiveness over a week.

If the paper is legitimate, then the effect could be better with weekly dosing and much better with twice-a-week dosing.

rolph•48m ago
it doesnt stop you from being infected, it is administered, in such dosage as to make the blood toxic to mosquitoes.

the reduction of infection is by reduction of mosquito population.

raffael_de•37m ago
This research must have been conducted by conspiracy nuts - after all Ivermectin is a horse dewormer and that's all you have to know about it (source: CNN)
jmclnx•21m ago
Well something needs to be done about malaria. Since there is no hope in solving Climate Change, seems malaria and other disease are slowing heading north.

I remember reading some nasty mosquito diseases already landed in Florida and Southern Texas. And seems malaria use to be as far north as NH.

So, if work does not start soon, malaria could cover a decent area of the US. Of course we know the politicians will completely ignore this threat and some may even say it is no worse than the common cold. Just look at the progress on Climate Change, if decent work was done on that 30+ years ago, it would have solved lots of potential issues.