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Scientists find ways to boost memory in aging brains

https://news.vt.edu/articles/2025/10/cals-jarome-improving-memory.html
57•stevenjgarner•2h ago

Comments

stevenjgarner•2h ago
Virginia Tech researchers have shown that memory loss in aging may be reversible. Using CRISPR tools, they corrected molecular disruptions in the hippocampus and amygdala, restoring memory in older rats. Another experiment revived a silenced memory gene, IGF2, through targeted DNA methylation editing. These findings highlight that aging brains can regain function through precise molecular intervention.
tom_•1h ago
"In mice", I thought to myself. But then I read the article - and how wrong I was!
chrisweekly•55m ago
Rats. I thought it'd be mice too.
knodi123•16m ago
but what about my senile mice? please, won't somebody think of them??
wzdd•56m ago
Looking forward to seeing the same generation of biohackers who previously CRISPRed their lactose intolerance to now CRISPR their hippocampi!
riggsdk•20m ago
For those curious, that is @thethoughtemporium on youtube.
twostorytower•24m ago
Download more ram!
BobbyTables2•19m ago
Funny how nobody has used CRISPR to make the body naturally produce caffeine…

You should write an agent

https://fly.io/blog/everyone-write-an-agent/
381•tabletcorry•6h ago•191 comments

Scientists find ways to boost memory in aging brains

https://news.vt.edu/articles/2025/10/cals-jarome-improving-memory.html
57•stevenjgarner•2h ago•8 comments

Game design is simple

https://www.raphkoster.com/2025/11/03/game-design-is-simple-actually/
142•vrnvu•4h ago•51 comments

A Note on Fil-C

https://graydon2.dreamwidth.org/320265.html
36•signa11•2h ago•7 comments

Kimi K2 Thinking, a SOTA open-source trillion-parameter reasoning model

https://moonshotai.github.io/Kimi-K2/thinking.html
604•nekofneko•12h ago•242 comments

Two billion email addresses were exposed

https://www.troyhunt.com/2-billion-email-addresses-were-exposed-and-we-indexed-them-all-in-have-i...
354•esnard•6h ago•244 comments

Show HN: I scraped 3B Goodreads reviews to train a better recommendation model

https://book.sv
269•costco•1d ago•99 comments

A prvalue is not a temporary

https://blog.knatten.org/2025/10/31/a-prvalue-is-not-a-temporary/
3•ingve•11m ago•40 comments

Analysis indicates that the universe’s expansion is not accelerating

https://ras.ac.uk/news-and-press/research-highlights/universes-expansion-now-slowing-not-speeding
107•chrka•6h ago•116 comments

Swift on FreeBSD Preview

https://forums.swift.org/t/swift-on-freebsd-preview/83064
187•glhaynes•9h ago•109 comments

Open Source Implementation of Apple's Private Compute Cloud

https://github.com/openpcc/openpcc
360•adam_gyroscope•1d ago•75 comments

LLMs encode how difficult problems are

https://arxiv.org/abs/2510.18147
109•stansApprentice•8h ago•21 comments

The Geometry of Schemes [pdf]

https://webhomes.maths.ed.ac.uk/~v1ranick/papers/eisenbudharris.pdf
18•measurablefunc•6d ago•3 comments

Eating stinging nettles

https://rachel.blog/2018/04/29/eating-stinging-nettles/
181•rzk•15h ago•170 comments

GT – Experimental multiplexing tensor framework for distributed GPU computing

https://github.com/bwasti/gt
10•brrrrrm•4d ago•0 comments

Hightouch (YC S19) Is Hiring

https://job-boards.greenhouse.io/hightouch/jobs/5542602004
1•joshwget•5h ago

FBI tries to unmask owner of archive.is

https://www.heise.de/en/news/Archive-today-FBI-Demands-Data-from-Provider-Tucows-11066346.html
725•Projectiboga•10h ago•379 comments

The Parallel Search API

https://parallel.ai/blog/introducing-parallel-search
95•lukaslevert•10h ago•36 comments

I analyzed the lineups at the most popular nightclubs

https://dev.karltryggvason.com/how-i-analyzed-the-lineups-at-the-worlds-most-popular-nightclubs/
141•kalli•13h ago•69 comments

Mathematical exploration and discovery at scale

https://terrytao.wordpress.com/2025/11/05/mathematical-exploration-and-discovery-at-scale/
229•nabla9•17h ago•113 comments

The secret campaign to silence critics of a hospital real estate empire

https://www.motherjones.com/politics/2025/10/medical-properties-trust-mpt-steward-health-care-ed-...
45•hhs•3h ago•1 comments

ICC ditches Microsoft 365 for openDesk

https://www.binnenlandsbestuur.nl/digitaal/internationaal-strafhof-neemt-afscheid-van-microsoft-365
536•vincvinc•10h ago•168 comments

Show HN: TabPFN-2.5 – SOTA foundation model for tabular data

https://priorlabs.ai/technical-reports/tabpfn-2-5-model-report
65•onasta•8h ago•11 comments

Auraphone: A simple app to collect people's info at events

https://andrewarrow.dev/2025/11/simple-app-collect-peoples-info-at-events/
39•fcpguru•12h ago•17 comments

I may have found a way to spot U.S. at-sea strikes before they're announced

https://old.reddit.com/r/OSINT/comments/1opjjyv/i_may_have_found_a_way_to_spot_us_atsea_strikes/
307•hentrep•22h ago•450 comments

Show HN: Auto-Adjust Keyboard and LCD Brightness via Ambient Light Sensor[Linux]

https://github.com/donjajo/als-led-backlight
8•donjajo•4d ago•1 comments

Show HN: See chords as flags – Visual harmony of top composers on musescore

https://rawl.rocks/
107•vitaly-pavlenko•1d ago•27 comments

Show HN: qqqa – A fast, stateless LLM-powered assistant for your shell

https://github.com/matisojka/qqqa
131•iagooar•16h ago•80 comments

How often does Python allocate?

https://zackoverflow.dev/writing/how-often-does-python-allocate/
89•ingve•5d ago•61 comments

How I am deeply integrating Emacs

https://joshblais.com/blog/how-i-am-deeply-integrating-emacs/
208•signa11•19h ago•146 comments