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Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
250•theblazehen•2d ago•84 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
23•AlexeyBrin•1h ago•1 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
705•klaussilveira•15h ago•206 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
967•xnx•21h ago•558 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
66•jesperordrup•6h ago•28 comments

Reinforcement Learning from Human Feedback

https://arxiv.org/abs/2504.12501
7•onurkanbkrc•43m ago•0 comments

Making geo joins faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
135•matheusalmeida•2d ago•35 comments

Where did all the starships go?

https://www.datawrapper.de/blog/science-fiction-decline
42•speckx•4d ago•34 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
68•videotopia•4d ago•6 comments

ga68, the GNU Algol 68 Compiler – FOSDEM 2026 [video]

https://fosdem.org/2026/schedule/event/PEXRTN-ga68-intro/
13•matt_d•3d ago•2 comments

Jeffrey Snover: "Welcome to the Room"

https://www.jsnover.com/blog/2026/02/01/welcome-to-the-room/
39•kaonwarb•3d ago•30 comments

What Is Ruliology?

https://writings.stephenwolfram.com/2026/01/what-is-ruliology/
45•helloplanets•4d ago•46 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
237•isitcontent•16h ago•26 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
237•dmpetrov•16h ago•126 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
340•vecti•18h ago•147 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
506•todsacerdoti•23h ago•247 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
389•ostacke•21h ago•97 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
303•eljojo•18h ago•188 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
361•aktau•22h ago•186 comments

Cross-Region MSK Replication: K2K vs. MirrorMaker2

https://medium.com/lensesio/cross-region-msk-replication-a-comprehensive-performance-comparison-o...
3•andmarios•4d ago•1 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
428•lstoll•22h ago•284 comments

PC Floppy Copy Protection: Vault Prolok

https://martypc.blogspot.com/2024/09/pc-floppy-copy-protection-vault-prolok.html
71•kmm•5d ago•10 comments

Was Benoit Mandelbrot a hedgehog or a fox?

https://arxiv.org/abs/2602.01122
23•bikenaga•3d ago•11 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
25•1vuio0pswjnm7•2h ago•14 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
96•quibono•4d ago•22 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
270•i5heu•18h ago•219 comments

Delimited Continuations vs. Lwt for Threads

https://mirageos.org/blog/delimcc-vs-lwt
34•romes•4d ago•3 comments

I now assume that all ads on Apple news are scams

https://kirkville.com/i-now-assume-that-all-ads-on-apple-news-are-scams/
1079•cdrnsf•1d ago•461 comments

Introducing the Developer Knowledge API and MCP Server

https://developers.googleblog.com/introducing-the-developer-knowledge-api-and-mcp-server/
64•gfortaine•13h ago•30 comments

Understanding Neural Network, Visually

https://visualrambling.space/neural-network/
305•surprisetalk•3d ago•44 comments
Open in hackernews

Sharper MRI scans may be on horizon thanks to new physics-based model

https://news.rice.edu/news/2025/sharper-mri-scans-may-be-horizon-thanks-new-physics-based-model
159•hhs•2mo ago

Comments

Insanity•2mo ago
After reading the article I get what it’s saying.. but isn’t any MRI _technically_ physics-based.
BobbyTables2•2mo ago
Does seem like advertising “rack and pinion” steering on a car…
Karliss•2mo ago
The term is "physics based model" it has somewhat specific meaning in context of mathemtical/physics modelling. It has nothing to do with all physics required to make MRI work. A model doesnt have to be based on physics to be usefull. You can often get some recognizable image by dumb stronger signal=> brighter pixel logic without fully modelling how why it changes. As long as change in material correlates with change in signal (doesn't even have to happen uniformly) you can get some picture and leave the interpretation to human. A simpler example would be temperature control. You can have simple hysteresis based approch of temperature under threshold turn on heater, above threshold turn off. Or you can have physics based model of what the heating power is, what's the heat capacity of chamber, what's the heat capacity of object, how the temperature diffuses within object, what's the thermal resistance of interfaces between heater, target and temperature sensor. Many everyday systems systems are controlled by generic PID controllers without physically modelling how exactly the process reacts to input, PID can be be considered a mathematical control model with sufficient parameterization to approximate various physical systems. You could also make an AI based model and create a signal processing function that way. For many drones PID coefficients are tuned by hand, it was quite a surprise when one of controller manufacurers had made a physics based model to calculate suitable defaults based on drone mass, momment of inertia and maximum thrust.

Technically the tittle isn't lying. Researchers created new physics based model which is more detailed and makes less simplifications compared to old physics based model. The qualification also clarifies that potentially sharper image won't be achieved by new device model or a picture of 3d model printed on marketing materials.

omnicognate•2mo ago
Nice that it's called physics-based rather than the grammatically weird "physically based" used in computer graphics.
iandanforth•2mo ago
FYI if you're getting a contrast MRI in the near future, avoid vitamin c. https://hscnews.unm.edu/news/unm-scientists-discover-how-nan...
chrisweekly•2mo ago
thanks
Roritharr•2mo ago
Getting one on Monday, have a slight cold and took liposomal vitamin c just hours ago!

Thanks for making me aware!

vlovich123•2mo ago
I thought I read that in general it’s just better to decline contrast because it doesn’t actually add value to the scan.
jmhmd•2mo ago
It depends on the indication for the scan. Some indications do not require contrast, others MUST have contrast in order to have any value. If you refuse contrast without understanding the reason, you may be simply wasting your time and money.
wolfi1•2mo ago
not only vitamin c but fruits containing oxalic acid if I read that right. But I'm far more interested in when such contrast agents are warranted, because I'm not aware that in Europe that contrast agent would be used that much for MRI
lurking_swe•2mo ago
see sections “Why Would I Need a Contrast MRI?” and “Which Types of MRI Require Contrast”

https://www.ashospital.net/blog/why-do-i-need-contrast-for-m...

dcminter•2mo ago
For your anecdata I'm in Sweden and definitely had a contrast agent (presumably gadolinium based) for a recent MRI of my gallbladder/pancreas/liver area.
mstade•2mo ago
Same here, also in Sweden.
dorfsmay•2mo ago
> previous research has shown that even in those with no symptoms, gadolinium particles have been found in the kidney and the brain and can be detected in the blood and urine years after exposure

So do you stop eating high oxilate and high vitamin C food for a year after the MRI? Are there foods or drinks that help flush gadolinium?

lostlogin•2mo ago
> I'm not aware that in Europe that contrast agent would be used that much for MRI

I’m a New Zealand MR tech. Based on the practice of my European colleagues, they give it just as often as we do.

3052•2mo ago
I'm in the UK and getting one to diagnose ED/recurrent priapism.
elric•2mo ago
I have one planned soon. Of course the prescribing doctor didn't mention any of this, but I guess the research is still too fresh. Thanks for raising awareness.
dwroberts•2mo ago
*If your scan involves contrast agent, which many do not
kyleblarson•2mo ago
My late grandfather had a severe reaction to contrast agent while getting an MRI and coded while in the machine. (They resuscitated him)
sschueller•2mo ago
Many variants seem to be banned in Europe [1]

[1] https://mblynchfirm.com/pharmaceutical-litigation/gadolinium...

Animats•2mo ago
Here's the paper.[1] No paywall this way; U.S. Government funded research. The paper claims an associated Github repository but there is no obvious link. There's no imagery in the paper, just the development of the math. So this may or may not help much.

[1] https://www.osti.gov/pages/servlets/purl/3001752

vbitz•2mo ago
I think the source code is here? https://github.com/pinheirothiagoj/NMR_Molecular_Eigenmodes_...
opello•2mo ago
Seems right to me, same link as in the PDF's Data Availability section.
dguest•2mo ago
Weird that I couldn't find the paper on arXiv: in my field I just google the title prefixed with "arXiv" and it pops up.

Some earlier articles by the same authors are there though (e.g. https://arxiv.org/abs/2310.06106), does the journal of chemical physics prohibit arXiv posting or is the norm just different in that field?

uecker•2mo ago
While this work is great, this will not directly lead to "sharper MRI scans". This is about better modelling of NMR signals, which may eventually lead to better MRI, but it is still pretty far away from imaging. If you want how we use simpler signal models in physics-based reconstruction to improve MR images, you can look at our paper: https://doi.org/10.1098/rsta.2020.0196
azalemeth•2mo ago
Indeed. Martin's a great name in the field -- the thing that has actually made most clinical proton MRI substantially better over the last twenty years has been parallel imaging (acquiring the magnetic resonance signal from different spatially separated devices known as RF coils) and associated reconstruction techniques such as compressed sensing.

Given the fact that macrocyclic gadolinium complexes accumulate in the brain and the linear ones dechelate I think very few companies are pursuing new agents. I've done some work with different ions (like Dy, which has Curie paramagnetism) but a lot of focus in the field is trying to find alternatives to gad and reduce its use. There are plenty of great ways of getting more info out of a machine that spans quantum mechanics to medicine, from the established but now actually useful and routine (like advanced diffusion models) to the sort of utterly mad techniques I work on... [0]

[0] https://www.science.org/doi/10.1126/sciadv.adz4334

olsondv•2mo ago
Advanced diffusion certainly benefited from the acquisition speed ups. That is its biggest challenge in my opinion preventing it from wider clinical adoption. It takes too long to get enough images for the models. Hyperpolarized MR will run into issue of lack of expertise in clinical imaging centers. There is already a shortage of good techs and MR companies are working to further automate the workflows. Unless there is a major benefit of the advanced techniques, people will stick to the bread and butter FSE and DWI.
alphydan•2mo ago
Funnily enough there's a different Martin (Martin Plenio) pushing the boundaries of MRI resolution using quantum effects (molecular hyperpolarization).

https://www.uni-ulm.de/nawi/institut-fuer-quantenoptik/ag-pr...

For a more technical intro, see https://arxiv.org/abs/2403.14521

uecker•2mo ago
Also cool, but it does not push the boundaries of MRI resolution. They try to bring a hyperpolarizer to market for a ¹³C-Pyruvate contrast agent, but it seems their hyperpolarizer is not yet certified. In any case, this will give metabolic information at low resolution so competes with PET.
ForOldHack•2mo ago
"However Gd is also retained in the brain, bone, skin, and other tissues in patients with normal renal function, and the presence of Gd can persist months to years after the last administration of a GBCA."

This is therapy. May persist... I want to throw this here, because there is a lot of discussion here by not only a few patients but a few very knowledgeable researchers which is surprising for such an extremely niche field, and the discussion is amazing.

ForOldHack•2mo ago
I suspected this was blahtering AI, and this confirms it: "By solving this equation, they were able to capture the full spectrum of molecular motion and relaxation." The equation is solved buddy, and has been since Plank solved it. It's the discreet calculation of its values give is a digital image that can be contrast enhanced by differing molecules, the physics has not changed, and the equation has not changed. <Downvote>
gosub100•2mo ago
> discreet calculation

why do they have to be discreet about doing some math? who is going to be bothered by it?

lostlogin•2mo ago
I assume OP means discrete and not discreet.

“Discreet and discrete are homophones. They sound the same but they have different definitions. Discreet means careful or intentionally unobtrusive. Discrete means distinct or unconnected.”

I learned something though.

https://www.grammarly.com/blog/commonly-confused-words/discr...

gosub100•2mo ago
If you have a bad Greek vacation, you can also Diss Crete.
tpoacher•2mo ago
sth sth "Disk-read" pun