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A 2026 look at three bio-ML opinions I had in 2024

https://www.owlposting.com/p/a-2026-look-at-three-bio-ml-opinions

17•abhishaike•3h ago

Comments

ViscountPenguin•1h ago

Any chance of raising the paywall on this article?

I was quite enjoying it, but then the paywall hit me right in the middle of the chemical synthesis section.

I have no problem with you wanting to earn money from your work, but it's a bit odd to post an unreadable article to hn (odd enough that I assume it was by mistake?).

The struggle of resizing windows on macOS Tahoe

https://noheger.at/blog/2026/01/11/the-struggle-of-resizing-windows-on-macos-tahoe/

730•happosai•4h ago•330 comments

CLI agents like Claude Code make self-hosting on a home server easier and fun

https://fulghum.io/self-hosting

229•websku•3h ago•148 comments

This game is a single 13 KiB file that runs on Windows, Linux and in the Browser

https://iczelia.net/posts/snake-polyglot/

68•snoofydude•2h ago•23 comments

iCloud Photos Downloader

https://github.com/icloud-photos-downloader/icloud_photos_downloader

289•reconnecting•5h ago•148 comments

I Cannot SSH into My Server Anymore (and That's Fine)

https://soap.coffee/~lthms/posts/i-cannot-ssh-into-my-server-anymore.html

64•TheWiggles•4d ago•24 comments

FUSE is All You Need – Giving agents access to anything via filesystems

https://jakobemmerling.de/posts/fuse-is-all-you-need/

58•jakobem•3h ago•19 comments

Sampling at negative temperature

https://cavendishlabs.org/blog/negative-temperature/

107•ag8•5h ago•38 comments

I'm making a game engine based on dynamic signed distance fields (SDFs) [video]

https://www.youtube.com/watch?v=il-TXbn5iMA

161•imagiro•3d ago•21 comments

I'd tell you a UDP joke…

https://www.codepuns.com/post/805294580859879424/i-would-tell-you-a-udp-joke-but-you-might-not-get

75•redmattred•2h ago•24 comments

Don't fall into the anti-AI hype

https://antirez.com/news/158

551•todsacerdoti•14h ago•729 comments

Elo – A data expression language which compiles to JavaScript, Ruby, and SQL

https://elo-lang.org/

41•ravenical•4d ago•5 comments

The Next Two Years of Software Engineering

https://addyosmani.com/blog/next-two-years/

45•napolux•3h ago•17 comments

Gentoo Linux 2025 Review

https://www.gentoo.org/news/2026/01/05/new-year.html

291•akhuettel•13h ago•147 comments

Insights into Claude Opus 4.5 from Pokémon

https://www.lesswrong.com/posts/u6Lacc7wx4yYkBQ3r/insights-into-claude-opus-4-5-from-pokemon

24•surprisetalk•5d ago•5 comments

A set of Idiomatic prod-grade katas for experienced devs transitioning to Go

https://github.com/MedUnes/go-kata

101•medunes•4d ago•13 comments

Perfectly Replicating Coca Cola [video]

https://www.youtube.com/watch?v=TDkH3EbWTYc

128•HansVanEijsden•3d ago•68 comments

A 2026 look at three bio-ML opinions I had in 2024

https://www.owlposting.com/p/a-2026-look-at-three-bio-ml-opinions

17•abhishaike•3h ago•1 comments

Ask HN: What are you working on? (January 2026)

139•david927•8h ago•463 comments

Rare Iron Age war trumpet and boar standard found

https://www.bbc.com/news/articles/cr7jvj8d39eo

7•breve•4d ago•0 comments

BYD's cheapest electric cars to have Lidar self-driving tech

https://thedriven.io/2026/01/11/byds-cheapest-electric-cars-to-have-lidar-self-driving-tech/

109•senti_sentient•4h ago•121 comments

Poison Fountain

https://rnsaffn.com/poison3/

161•atomic128•7h ago•104 comments

Show HN: What if AI agents had Zodiac personalities?

https://github.com/baturyilmaz/what-if-ai-agents-had-zodiac-personalities

7•arbayi•1h ago•1 comments

Anthropic: Developing a Claude Code competitor using Claude Code is banned

https://twitter.com/SIGKITTEN/status/2009697031422652461

226•behnamoh•5h ago•137 comments

Quake 1 Single-Player Map Design Theories (2001)

https://www.quaddicted.com/webarchive//teamshambler.planetquake.gamespy.com/theories1.html

40•Lammy•19h ago•2 comments

"Food JPEGs" in Super Smash Bros. & Kirby Air Riders

https://sethmlarson.dev/food-jpegs-in-super-smash-bros-and-kirby-air-riders

254•SethMLarson•5d ago•64 comments

"Scholars Will Call It Nonsense": The Structure of von Däniken's Argument (1987)

https://www.penn.museum/sites/expedition/scholars-will-call-it-nonsense/

50•Kaibeezy•5h ago•6 comments

I dumped Windows 11 for Linux, and you should too

https://www.notebookcheck.net/I-dumped-Windows-11-for-Linux-and-you-should-too.1190961.0.html

723•smurda•13h ago•685 comments

Meta announces nuclear energy projects

https://about.fb.com/news/2026/01/meta-nuclear-energy-projects-power-american-ai-leadership/

241•ChrisArchitect•6h ago•247 comments

C++ std::move doesn't move anything: A deep dive into Value Categories

https://0xghost.dev/blog/std-move-deep-dive/

226•signa11•2d ago•183 comments

iMessage-kit is an iMessage SDK for macOS

https://github.com/photon-hq/imessage-kit

21•rsync•3h ago•5 comments