re: the article itself, they concentrate only on brain regions which have high density of CB1 expression and that's reasonable. But CB1 is not the only CNS cannabinoid receptor (CB2 mostly expressed peripherally). There's also GPR55 which is activated by cannabinoids like THC. A little issue which could be addressed in future work.

https://cheflindseyfarr.com/marinated-tomato-stone-fruit-sal...

(I second the recommendation of adding burrata.)

Wisdom is understanding that if there was legislation on the matter, and people who ate, produced, or sold non-tomato fruits were hunted and deprived of their freedoms by the state on the basis that fruits are bad for society, then you would likely see similar frustrations expressed about an article title that includes the phrase "tomatoes and fruits" to distinguish them.

Do they mean 'That is a slab.' or 'Hand me that slab.'?

Context matters. There is no correct answer. There are no metaphysical truth particles that shake 'True!'. Expressivism, how you feel about the statement, is going to decide what you think.

Anyway, I used to intentionally say things like "I love drugs, although its specifically Caffeine."

But that's presumably why the parent commenter spoke up in the first place.

Industry-fueled self-delusion can be intercepted if we make the effort to do so.

We see a distinction for that one, just like we do for alcohol.

Agreed completely on the day drinking point. That’s actually what got me to quit initially years ago. I realized, would I be drinking right now before work? Hell no. So why am I okay with getting high?

Have you tried blending in CBD?

Typically I smoke small joints with 90% CBD strains and the rest a high THC strain, only thing I can smoke.

For me, the downsides manifest as drarticlsly increased anxiety (I naturally have next to none), extremely poor sleep - I sleep but the sleep is so low quality it begins to feel like my brain barely works right, and the obvious one, the effects on your motivation. I naturally tend towards ADHD style dopamine chasing, and weed makes that about 100x worse. Instead of getting my work done, I will procrastinate with any number of cheap dopamine hits such as video games, internet sleuthing, etc.

I think part of it is the crowd you end up in when you smoke weed. Unsurprisingly, drug use lends itself to putting you in situations with other drug users. These users often completely ignore, leave out, or outright lie about the downsides of these drugs, from chronic weed use to LSD.

I know lots of people that smoke heavily and I've watched their trajectory over decades. It's a sad story really. I'm pretty sure if you manage it responsibly the benefits may well outweigh the downsides but over the long term it really adds up.

Of course, everybody ages, and people are not usually as sharp as they were in their twenties or earlier. But given that I also have access to a sizeable control group where I don't see that effect I figure it has to have some factual basis too large to be just handwaved away.

Feel free to correct the fact that we haven't met in person by the way, you & yours are always welcome here.

https://thereitis.org/mr-x-by-carl-sagan/

He originally wrote about it under a pseudonym for fear of professional consequences. Many such cases.

Yes, I know some of those. But usually they are either very light users or they achieved their success before becoming heavy users.

I also know some pretty heavy users that are adamant that they are doing better than before but their environment does not usually agree. This is a thing that is fairly common with heavy drug users though.