Anyone using it with nodejs to make a sandbox for code agents?

no but it works great in conjunction with observable and d3js for pretty interactives!

It works surprisingly well in terms of writing python for native execution, and then trying to share on the web and having it Just Work TM. Unfortunately, when I want python it's because I want numpy, scipy and friends, and once you bring them on board pyodide load times are long. As an example comparison: a face turning octahedron puzzle in python + pyodide, loads in 10 seconds https://cubes.hgreer.com/fto.html . Meanwhile, a megaminx puzzle in javascript (statically generated by python) loads in 200 ms https://cubes.hgreer.com/ssg/output.html

Pyodide is one of the hidden gems of the Python ecosystem. It's SO good at what it does, and it's nearly 8 years old now so it's pretty mature.

I love using Pyodide to build web UIs for trying out new Python libraries. Here's one I built a few weeks ago to exercise my pure-Python SQLite AST parser, for example: https://tools.simonwillison.net/sqlite-ast

It's also pretty easy[1] to get C or Rust libraries that have Python bindings compiled to a WebAssembly wheel that Pyodide can then load.

Here's a bit of a nutty example - the new Monty Python-like sandbox library (written in Rust) compiled to WASM and then loaded in Pyodide in the browser: https://simonw.github.io/research/monty-wasm-pyodide/pyodide...

[1] OK, Claude Code knows how to do it.

There's also xeus-cpp which is cpp based on wasm. Xeus-cpp and pyodide are the backends for Jupyterlite [1] kernels in browser.

It's actually a very good way to teach coding in python/c++(11, 17 or even 23), explore language features or your own library within browser and allow students to execute code by hosting just some static html pages and some assets without any backend.

1. https://jupyter.org/try-jupyter/lab/

Yea, I even built online ide based on Pyodide. Insane peace of software. You can try here: playcode.io/python