https://pubmed.ncbi.nlm.nih.gov/41160460/#:~:text=ResultsAt%...
But somehow I doubt it will be found to be that effective.
Now that it's legal and everywhere, I just get super fun panic attacks. I'm worthless, I'm failing as a parent, everybody hates me, you know, the normal anxiety attacks. Even Charlotte's Web that's SUPER low THC gives me panic attacks.
It's like my body hates it when I'm happy? I would give anything to be able to fix this problem.
1. I've eaten like crap. Things too heavy I'm grease, processed food, and red meats. When I'm rating cleaner, I don't feel as panicky
2. If I feel the panic coming on, I HAVE to do some sort of aerobic exercise in that first 15 minute "induction" phase of smoking. Otherwise I'll carry the panic along through the entire session.
FWIW, YMMV
Saw someone literally suggesting keeping a CBD vape pen just in case of a panic attack. Or a friend using it for heart palpitations.
Wasn't the amount of THC concentration in resin seen as the indicator of potency? Then that amount was hacked through selective breeding, unbeknownst that not following with a complementary increase in amount of CBD will create an anxiety causing superdrug.
I experienced it once - on a party in a country where CBD strains are legal to buy by anyone, as long as they contain ~0%THC. And high quality high THC strains can be bought at a pharmacy with a prescription.
A friend rolled a 50%/50% joint, approx 0.5g total, and we proceeded to smoke it whole, just the two of us. I was surprised you could get that high without a shadow of a paranoia.
But fortunately there's a much better solution for those of us who get anxiety from weed, it's called "don't smoke weed".
In my defense, it may have been a stupid joke but it's not as stupid as trying to prevent brain damage by taking cannabinoids at levels known to cause brain damage.
I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in this study appear to be in the same range where things start getting really disrupted in cells.
In other words, don’t expect to replicate these results with normal recreational use.
Actually, I think even by 2016 we already had enough phase 3 drug failures that the amyloid hypothesis was severely called into question?
anjel•2h ago
whycome•2h ago
And also, apparently, the registered trademark?
> The researchers found that high levels of amyloid beta were associated with cellular inflammation and higher rates of neuron death. They demonstrated that exposing the cells to THC reduced amyloid beta protein levels and eliminated the inflammatory response from the nerve cells caused by the protein, thereby allowing the nerve cells to survive.
magospietato•1h ago