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Overestimation of microplastics potentially caused by scientists' gloves

https://news.umich.edu/nitrile-and-latex-gloves-may-cause-overestimation-of-microplastics-u-m-study-reveals/
134•giuliomagnifico•3h ago

Comments

giantg2•1h ago
Classic. This is like that female serial killer in Europe that turned out to actually just be DNA from a woman making the DNA collection swabs.
thebruce87m•1h ago
I thought that exact thing and opened the comments to see you’d already commented with it.

There is a “case files” podcast on it that I found quite good.

vlz•1h ago
This seems to be the Casefile episode about the "Phantom of Heilbronn"

https://casefilepodcast.com/case-178-the-woman-without-a-fac...

alsetmusic•57m ago
That's incredible. Though the effect of this will be claims that microplastics don't exist while no one in that case claimed that murders didn't happen. Happy to have learned about an interesting historical oddity either way.
pell•1h ago
Interestingly, contamination of the forensic equipment was considered early on already. However, due to the geographic area of the findings and initial negative control tests using fresh swabs, they ruled it out.
MagicMoonlight•1h ago
That’s why you’re supposed to submit an unused swab with the samples, so that they can make sure the swab itself isn’t the source.
wewewedxfgdf•1h ago
That's a relief. Now I can stop worrying about microplastics. Just like the environment - we don't hear much about it any more, so they must have sorted that out too. Didn't they? Did they?
_fizz_buzz_•1h ago
The article specifically says the opposite.
darkerside•1h ago
So the problem is these particles are literally flying off the gloves of the scientists wearing them to the point it's interfering with the experiment and so... it's less of a problem?
sd9•1h ago
Huh, good point
stef25•1h ago
Well, it could mean more microplastics occur in an unnatural environment (the lab) containing much more plastics than in a typical home setting.

If you're around plastic a lot you're ingesting a lot and if you're not, you're not.

So the conclusion would be that plastics "sheds" and you should avoid it in packaging, kitchen utensils, etc

xienze•1h ago
Yes? Most people don’t live their entire lives in a lab wearing nitrile gloves, so there’s an argument to be made that the concentration of microplastics found in that setting is not reflective of everyday life.

So, not that microplastics don’t exist, but that they don’t exist to the same degree as in a lab environment.

formerly_proven•54m ago
I wouldn't be surprised if e.g. all these paper-thin synthetic (plastic) disposable parts and fabrics used in labs shed microplastics way more than e.g. synthetic fabrics designed to be survive a machine wash a few dozen times, or upholstery meant to withstand tens of thousands of sitting cycles, nevermind solid plastics (e.g. reusable food containers, furniture surfaces).
jofer•1h ago
It's not microplastics coming from the gloves. It's particles of the powder used to coat the gloves and keep them from sticking. Different composition, but similar and easily mistaken.
XorNot•1h ago
If you read the article you'd find that what they are finding are not microplastics - they're stearates[1]

These are soap-like chemicals used as mould release agents on gloves, but what also means are chemically similar to plastics when analyzed by some techniques and under a microscope will spontaneously form micelle-structures which look very similar to microplastics (you can't exactly get in there and poke them).

[1] https://en.wikipedia.org/wiki/Stearic_acid

scorpionfeet•1h ago
“if you read the article”

Now why would anyone do that when the headline already supports their uninformed opinion?

jevogel•1h ago
No, the gloves leave stearates (not plastic, but similar looking particles) residue on contact. So there are not literally micro plastics flying off the gloves. Read the article.
throwup238•1h ago
Called it!

> To be honest, after reading some of these microplastics papers I'm starting to suspect most of them are bullshit. Plastics are everywhere in a modern lab and rarely do these papers have proper controls, which I suspect would show that there is a baseline level of microplastic contamination in labs that is unavoidable. Petri dishes, pipettes, microplates, EVERYTHING is plastic, packaged in plastic, and cleaned using plastic tools, all by people wearing tons of synthetic fibers.

> We went through this same nonsense when genetic sequencers first became available until people got it into their heads that DNA contamination was everywhere and that we had to be really careful with sample collection and statistical methods.

[1]

[1] https://news.ycombinator.com/item?id=40681390

gww•1h ago
I haven't really read the studies but shouldn't they have negative controls to negate these effects? Wouldn't that let the author's correct for a baseline contamination level in the lab?
codebje•1h ago
On the one hand, hundreds or perhaps thousands of studies might be wrong. On the other hand, this one might be wrong. Who's to say?
estearum•55m ago
Not even that! This study doesn't even say contamination is causing overestimation. It says that it's possible.

But as mentioned elsewhere in the thread, everyone knows that it's possible and take measure to mitigate it.

A paper that said those mitigations were insufficient or empirically found not to work would be interesting. A paper saying "you should mitigate this" is... not very interesting.

xienze•16m ago
> Not even that! This study doesn't even say contamination is causing overestimation. It says that it's possible.

From the article:

> They found that on average, the gloves imparted about 2,000 false positives per millimeter squared area.

I dunno, that seems like a lot of false positives. Doesn’t that strongly imply that overestimation would be a pretty likely outcome here? Sounds like a completely sterile 1mm^2 area would raise a ton of false positives because of just the gloves.

throwup238•52m ago
That has happened many times in scientific research. The aforementioned fad in DNA sequencing was one such case where tons of papers before proper methods were developed are entirely useless, essentially just garbage data. Another case is fMRI studies before the dead salmon experiment.
throwup238•56m ago
That was the difficulty with DNA: how do you make that control if everything is contaminated and minor variations in protocol (like wafting your hands over the samples one too many times) changes the baseline?

It took years to figure out proper methods and many subfields have their own adjusted procedures and sometimes even statistical models. At least with DNA you could denature it very effectively, I’m not sure how they’re going to figure out the contamination issue with microplastics.

gww•23m ago
I have worked at a sequencing center before. DNA contamination is easier to mitigate because the lab disposables aren't made out of what you are testing. Disposables are almost always plastic and tend to have minimal DNA contamination. Environmental DNA contamination is largely mitigated with PCR hoods and careful protocols/practices. However, these procedures don't mitigate DNA contamination at the collection level, which is likely where the statistical models you mentioned help.

I can't imagine wafting your hands over the tubes would change the plastic amounts substantially compared to whatever negative controls the papers used. But again, I am not an expert on this kind of analytical chemistry. I always worry more about batch effects. But it does seem like microplastics are becoming the new microbiome.

globemaster99•1h ago
Carl Sagan was right all along. Always question science, never trust these so called experts, do your own assessment, research and thinking. This must be another global climate change scam.
harladsinsteden•1h ago
> Do your own assessment.

Yeah, and my primitive home-grown analysis then carries the same weight as those from experts with professional equipment? Oh come on...

Dilettante_•1h ago
Doesn't have to be one or the other. Trust, but verify? Experts make mistakes, professional equipment can be mishandled. Don't take anybodies word, look at the evidence for yourself.

This is a very scientific way of thinking. It's only gotten a bad rap on account of people using it to attack others' research and then(crucially) failing to perform their own.

globemaster99•56m ago
True, trust but verify and start questioning things. Science is now more politicized more than ever by politicians. COVID vaccines are not even tested. I didn't said this. Pfizer and Moderna CEO said this in EU parliament hearing.
estearum•49m ago
Lol, the COVID vaccines went through some of the largest randomized controlled trials ever conducted and had some of the best safety and efficacy results ever seen.

You might have heard that it wasn't tested for reducing transmission, i.e. whether the vaccines make it less likely that an infected, vaccinated person would transmit the virus to someone else... Which it wasn't, because uhhh... how would you?

They tested it for safety, reduction in symptomatic infection rate and reduction in infection severity.

You should set aside your conclusions for a bit and take an earnest effort at learning some of the details of this stuff if you want to "do your own research" etc. It is clear you are misunderstanding some pretty fundamental things that are actually easily understandable if you approach them with honest curiosity!

You can literally look up the trial designs and they just say right on them exactly what they're testing for and how they're doing it.

sarchertech•40m ago
We have more data on COVID vaccines that nearly every drug in existence.

My wife was one of the first pregnant women to get the vaccine (outside of trials) because she’s an ER doctor, and she’s had regular follow-up surveys from the CDC for years.

gus_massa•40m ago
>> COVID vaccines are not even tested

Do you have a link to the exact quote?

IIRC they have a 95% reduction in hospitalization rate, measured in a double blind human trial. [Compare that with the vector virus and inactivated virus vaccines, that have like a 65% reduction in hospitalization rate, measured in a double blind human trial.]

pfdietz•28m ago
Which reminds me, I need to arrange my biannual COVID booster.
croes•9m ago
The claim wasn’t it wasn’t tested but that it wasn’t tested for transmission prevention.

Still false

https://www.rmit.edu.au/news/factlab-meta/viral-pfizer--admi...

ivell•1h ago
It is partially correct. Except make sure you have the necessary skills to question the science. Intuition in these things are quite misleading. Don't start questioning cancer reports just because you don't feel sick.If you really don't trust it, get a relevant medical degree or take second opinions from those who are really qualified and not some quacks. Otherwise you would just end up dead.
greenavocado•15m ago
The problem is the wholesale erosion of belief in institutions after the COVID "vaccine" situation
Forgeties79•22m ago
I guarantee you Carl Sagan was not telling you to dismiss experts and he very much understood climate change was real. He literally testified before Congress on it, likely decades before you were even born.

It is generally bad practice to so drastically twist somebody’s words to make them say the opposite of what they’re saying. Carl Sagan would not agree with you.

khalic•1h ago
This study assumes everybody is oblivious to contamination, and explicitly says they can't differentiate. Not useful and bordering on the tautological
inglor_cz•1h ago
While we are used to associate "the observer effect" with particle physics, it can appear in biology and/or chemistry as well.

Keeping things meticulously clean on the microscopic level is a complicated task. One of the many reasons why so few EUV chip fabs even exist.

amelius•26m ago
By that same effect we probably introduced life on Mars already.
lokinork•1h ago
As per usual, they get the result then go back to do the study. Been happening in economics forever too.
BoredPositron•1h ago
ITT people that only read the headline.
fHr•58m ago
Didnt they use for newest studies to detect microplastic in placentas I think only non plastic omitting alternative gloves and material. Can't recall there it was specifically mentioned in a worldclass ARTE docu about microplastics maybe some ARTE Ultras here can recall.
keeperofdakeys•53m ago
Reminds me of the story of Polywater. https://en.wikipedia.org/wiki/Polywater
thomasgeelens•47m ago
this feels like such a weird oversight in such a controlled environment: "oh my bad it was the gloves!" I wonder in how many other studies this happened?
zug_zug•30m ago
This is good news, probably. We'll have to wait and see which studies replicate and which don't.
dust42•19m ago
So basically the gloves that kitchen staff now must wear means we get an extra dose of micro plastics? Yikes.
firesteelrain•8m ago
It says similar.

“ Stearates are salts, or soap-like particles. Manufacturers coat disposable gloves with stearates to make them easier to peel from the molds used to form them. But stearates are also chemically very similar to some microplastics, according to the researchers, and can lead to false positives when researchers are looking for microplastic pollution.”

Stearates aren’t microplastics. Maybe we need to be concerned with stearate pollution too.

krautburglar•19m ago
Smells like BS to me. The usual

    There are no conflicts to declare.
means nothing these days. There are so many ways to indirectly reward people for keeping your gravy train on the tracks.
jordanb•13m ago
Just the fact that the lab gets to publish something that's regime-friendly is beneficial to them.

Why was the study funded through the humanities department?

Mordisquitos•16m ago
I'm amazed that wasn't taken into account! Many years ago, in the final year of my Biology degree, I did a paid summer internship at an Evolutionary Biology lab here in Spain, assisting in a project where they were researching relationships between metal ion accumulation (mostly zinc) and certain SNPs (≈"gene varieties"). A lot of my work was in slicing tiny fragments of deep-frozen human livers and kidneys in a biosafety cabinet over dry ice.

The reason I bring this up is because the researchers had taken the essential precaution of providing me with a ceramic knife to do the cutting (and platic pliers), to eliminate the risk of contaminating the samples with metal from ordinary cutting implements.

That some research on microplatics did not take into account the absolutely mental amount of single-use plastic that is involved in biological research, particularly gloves of all things, boggles the mind.

tasuki•6m ago
So you're saying microplastics aren't a problem, because there's too much microplastics in gloves??

Overestimation of microplastics potentially caused by scientists' gloves

https://news.umich.edu/nitrile-and-latex-gloves-may-cause-overestimation-of-microplastics-u-m-stu...
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