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Training mRNA Language Models Across 25 Species for $165

50•maziyar•2d ago
We built an end-to-end protein AI pipeline covering structure prediction, sequence design, and codon optimization. After comparing multiple transformer architectures for codon-level language modeling, CodonRoBERTa-large-v2 emerged as the clear winner with a perplexity of 4.10 and a Spearman CAI correlation of 0.40, significantly outperforming ModernBERT. We then scaled to 25 species, trained 4 production models in 55 GPU-hours, and built a species-conditioned system that no other open-source project offers. Complete results, architectural decisions, and runnable code below.

Comments

maziyar•2d ago
full article: https://huggingface.co/blog/OpenMed/training-mrna-models-25-...
xyz100•2h ago
What makes this dataset or problem worth solving compared to other health datasets? Would the results on this task be broadly useful to health?
CyberDildonics•51m ago
What other "datasets" are you talking about? How do you "solve a dataset" ?
HocusLocus•2h ago
gray goo of the future
khalic•2h ago
> In Progress: CodonJEPA

JEPA is going to break the whole industry :D

digdugdirk•1h ago
Can you explain this? I haven't heard of JEPA, and from a quick search it seems to be vision/robotics based?
lukeinator42•1h ago
https://openreview.net/pdf?id=BZ5a1r-kVsf
khalic•54m ago
It’s a self supervised learning architecture, and it’s pretty much universal. The loss function runs on embeddings, and some other smart architectural choices allover. Worth diving into for a few hours, Yann LeCun gives some interesting talks about it
simianwords•2h ago
What makes these Domain specific models work when we don’t have good domain models for health care, chemistry, economics and so on
colechristensen•1h ago
>we don’t have good domain models for health care, chemistry, economics and so on

Who says we don't?

simianwords•58m ago
Examples please?
colechristensen•23m ago
No, it's really simple to search for domain specific models being used "in production" all over the place
simianwords•20m ago
I didn’t find a single one that outperforms a general model.
rubicon33•1h ago
Can someone explain what one might use this model for? As a developer with a casual interest in biology it would be fun to play with but honestly not sure what I would do
colechristensen•1h ago
You can get your feet wet with genetic engineering for surprisingly little money.

This guy shows a lot of how it's done: https://www.youtube.com/@thethoughtemporium

Basically you can design/edit/inject custom genes into things and see real results spending on the scale of $100-$1000.

someuser54541•56m ago
Is there something like this in text/readable format?
yieldcrv•1h ago
Distributing the load on this will probably be infinitely more useful than “folding at home”

Show HN: A game where you build a GPU

https://jaso1024.com/mvidia/
58•Jaso1024•50m ago•6 comments

Simple self-distillation improves code generation

https://arxiv.org/abs/2604.01193
362•Anon84•7h ago•110 comments

12,000 AI-generated blog posts added in a single commit

https://github.com/OneUptime/blog/commit/30cd2384794c897d95aca77d173db44af51ca849
28•noslop•51m ago•5 comments

Show HN: TurboQuant-WASM – Google's vector quantization in the browser

https://github.com/teamchong/turboquant-wasm
49•teamchong•2h ago•2 comments

Show HN: sllm – Split a GPU node with other developers, unlimited tokens

https://sllm.cloud
31•jrandolf•2h ago•19 comments

Some Unusual Trees

https://thoughts.wyounas.com/p/some-unusual-trees
169•simplegeek•8h ago•51 comments

Tell HN: Anthropic no longer allowing Claude Code subscriptions to use OpenClaw

929•firloop•18h ago•719 comments

Apple approves driver that lets Nvidia eGPUs work with Arm Macs

https://www.theverge.com/tech/907003/apple-approves-driver-that-lets-nvidia-egpus-work-with-arm-macs
60•naves•1h ago•11 comments

Author of "Careless People" banned from saying anything negative about Meta

https://www.thetimes.com/uk/technology-uk/article/sarah-wynn-williams-careless-people-meta-nrffdfpmf
323•macleginn•2h ago•230 comments

Components of a Coding Agent

https://magazine.sebastianraschka.com/p/components-of-a-coding-agent
54•MindGods•4h ago•15 comments

Artemis II crew take “spectacular” image of Earth

https://www.bbc.com/news/articles/ce8jzr423p9o
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The Cathedral, the Bazaar, and the Winchester Mystery House

https://www.dbreunig.com/2026/03/26/winchester-mystery-house.html
105•dbreunig•3d ago•43 comments

The Indie Internet Index – submit your favorite sites

https://iii.social
15•freshman_dev•3h ago•2 comments

Training mRNA Language Models Across 25 Species for $165

50•maziyar•2d ago•17 comments

Electrical Transformer Manufacturing Is Throttling the Electrified Future

https://www.bloomberg.com/features/2025-bottlenecks-transformers/
14•toomuchtodo•2d ago•3 comments

Mbodi AI (YC P25) Is Hiring

https://www.ycombinator.com/companies/mbodi-ai/jobs/mf9L3sy-senior-robotics-engineer-systems-cont...
1•chitianhao•5h ago

Claude Code Found a Linux Vulnerability Hidden for 23 Years

https://mtlynch.io/claude-code-found-linux-vulnerability/
237•eichin•17h ago•145 comments

What life looks like on the most remote inhabited island

https://apps.npr.org/life-on-tristan-da-cunha/
24•brightbeige•1h ago•4 comments

The most-disliked people in the publishing industry

https://www.woman-of-letters.com/p/the-most-disliked-people-in-the-publishing
66•Caiero•3d ago•23 comments

OpenClaw privilege escalation vulnerability

https://nvd.nist.gov/vuln/detail/CVE-2026-33579
480•kykeonaut•1d ago•222 comments

iNaturalist

https://www.inaturalist.org/
496•bookofjoe•1d ago•118 comments

The smallest ELF executable (2021)

https://nathanotterness.com/2021/10/tiny_elf_modernized.html
29•michelangelo•3d ago•1 comments

Herbie: Automatically improve imprecise floating point formulas

https://herbie.uwplse.org/doc/latest/tutorial.html
183•summarity•4d ago•33 comments

When legal sports betting surges, so do Americans' financial problems

https://www.npr.org/2026/04/04/nx-s1-5773354/legal-sports-betting-research-credit-bankruptcy
22•pseudolus•2h ago•9 comments

Run Linux containers on Android, no root required

https://github.com/ExTV/Podroid
193•politelemon•19h ago•70 comments

German men 18-45 need military permit to leave country for longer than 3 months

https://www.dw.com/en/german-men-need-military-permit-for-extended-stays-abroad/a-76662677
178•L_226•1h ago•203 comments

Astronomers Find a Third Galaxy Missing Its Dark Matter

https://www.universetoday.com/articles/astronomers-find-a-third-galaxy-missing-its-dark-matter-va...
6•gostsamo•23m ago•0 comments

Iran's Network of Cameras Bolsters Air Defenses, Expert Says

https://www.wsj.com/livecoverage/iran-war-news-2026/card/iran-s-network-of-cameras-bolsters-air-d...
7•uxhacker•30m ago•0 comments

Improving my focus by giving up my big monitor

https://ounapuu.ee/posts/2026/04/01/focus/
163•Fudgel•3d ago•160 comments

We replaced RAG with a virtual filesystem for our AI documentation assistant

https://www.mintlify.com/blog/how-we-built-a-virtual-filesystem-for-our-assistant
373•denssumesh•1d ago•144 comments