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UCLA discovers first stroke rehabilitation drug to repair brain damage (2025)

https://stemcell.ucla.edu/news/ucla-discovers-first-stroke-rehabilitation-drug-repair-brain-damage
69•bookofjoe•3h ago

Comments

benoau•3h ago
> “The goal is to have a medicine that stroke patients can take that produces the effects of rehabilitation,” said Dr. S. Thomas Carmichael, the study’s lead author and professor and chair of UCLA Neurology. “Rehabilitation after stroke is limited in its actual effects because most patients cannot sustain the rehab intensity needed for stroke recovery.

Sounds truly amazing, I have known two people who had severe strokes - one's PT was contingent on triaging resources to whoever was likely to recover more, another simply hated PT and speech therapy and often refused to participate or do the exercises. Even if it didn't help recovery a medicine like this would have reduced the stress of everyone involved.

mlmonkey•1h ago
Are there any supplements that can work for neurogenesis? I've heard Lions Mane extract can do this, but I'm not sure. Anybody know of anything?
dirtbagskier•1h ago
Cardiovascular exercise and strength training. Both are thought to contribute to neurogenesis, even in healthy people
throwforfeds•1h ago
There's (minimal) research on psilocybin doing just that. One of the tragedies of prohibition is that we just weren't able to study these psychedelic compounds easily for 50+ years.
toasty228•53m ago
If you don't sleep 8+ hours a day every single day, exercise regularly, live in a place with clean air, eat clean food, don't drink alcohol, etc. you're losing your time, no amount of supplement will make up for our modern way of life, you're going to optimise the 0.1% while missing the 99.9% that matters
SilentM68•28m ago
That is true, but keep in mind that routine is very difficult to do for someone that makes their living running the rat race, with stress, no time, responsibilities, worry, untreated health problems, etc. If you have the money, job security, then you'll have peace of mind. That will then allow one to live that kind of optimized lifestyle.
rexpop•9m ago
This is why we cannot abide scabs.
caycep•35m ago
Of note, cautionary tale is too much neurogenesis is brain cancer...
dymk•27m ago
No, brain cancer is brain cancer.
NDlurker•31m ago
Noopept

https://en.wikipedia.org/wiki/Omberacetam

sysreq_•19m ago
Nicotine is the only psychoactive substance proven to increase intellectual function. Rote neurogenisis does not - much in the same way height isn’t a proxy for IQ. Stimulants like Adderall, Caffiene, etc are Dunning-Kruger by proxy.
seabass-salmon•1h ago
Wonder what criteria they're using to define "first" here, as I'm aware Clinuvels afamelanotide treatment had positive results (though they're not proceeding with it currently as the burdensome regulatory processes make it too risky to have too many pots on the boil) https://biotechdispatch.com.au/news/clinuvel-announces-posit...
caycep•36m ago
It really depends on how much the company wants to invest. If it really worked, then it would be relatively straightforward for them to put together a Phase II. Not cheap, but relatively straightforward. Or at least it would have been when we had a functioning FDA

Also, the other definition in question is what the UCLA PR person means by "repairing brain damage". As far as I can tell from the paper - the "drug" part was using some neurotransmitter blockers on brain cells on a Petri dish to see if they could change gene expression or oscillatory firing patterns matching recordings in mice undergoing "physical therapy". They did not actually test to see if the stuff grew new brain cells or dendritic connections.

0xWTF•34m ago
... in male mice.

I think savvy universities want savvy PIs are savvy enough to realize that the point of these is to boost measurable visibility like citation count and h-index, so the headline of a news release boosting the article doesn't matter. They can always blame a copy editor for the headlines. It could read "world peace solved with moon juice." The provost would only care if it generated negative feedback. So it's the PR department's job to juice it as much as possible without getting blowback.

somewhatgoated•31m ago
Isn’t that where all drugs start out? But yea the headline doesnt tell the full story
KnuthIsGod•32m ago
Potentially life changing for male mice...
bawolff•25m ago
People go on about this too much. Its the first step, it shows promise.

Does that mean it will neccesarily work? No, of course not. But its still exciting to see progress being made.

functionmouse•9m ago
very happy for those mice
MattCruikshank•11m ago
If you've read Ted Chiang's "Understand," you'll understand why this headline made my eyes pop out. For those who haven't, it's in the "Stories of Your Life and Others" collection, which includes the short story that the film Arrival was based on.
naxios_official•10m ago
Interesting read. The history of early software companies and their culture is always fascinating. There's a lot modern startups could learn from that era's approach to building products.

Library for fast mapping of Java records to native memory

https://github.com/mamba-studio/TypedMemory
57•joe_mwangi•1h ago•17 comments

UCLA discovers first stroke rehabilitation drug to repair brain damage (2025)

https://stemcell.ucla.edu/news/ucla-discovers-first-stroke-rehabilitation-drug-repair-brain-damage
74•bookofjoe•3h ago•23 comments

Nullsoft, 1997-2004 (2004)

https://slate.com/technology/2004/11/the-death-of-the-last-maverick-tech-company.html
182•downbad_•3d ago•56 comments

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152•speckx•3h ago•69 comments

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491•negura•14h ago•342 comments

I let AI build a tool to help me figure out what was waking me up at night

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7•showmypost•27m ago•0 comments

Google says criminal hackers used AI to find a major software flaw

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9•donohoe•8h ago•1 comments

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315•adamnemecek•5h ago•98 comments

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6•samizdis•4d ago•1 comments

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151•littlexsparkee•2d ago•62 comments

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From Buffon's Needle to Buffon's Noodle

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https://user8.bearblog.dev/rant/
5•James72689•3d ago•0 comments

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7•ab613•1h ago•4 comments

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285•movis•6h ago•488 comments

The greatest shot in television: James Burke had one chance to nail this scene (2024)

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327•susam•18h ago•182 comments

Hardware Attestation as Monopoly Enabler

https://grapheneos.social/@GrapheneOS/116550899908879585
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Guitar tuner that uses phone accelerometer

https://tautme.github.io/phone-sensors/accel-tuner.html
142•adm4•3d ago•84 comments

Local AI needs to be the norm

https://unix.foo/posts/local-ai-needs-to-be-norm/
1728•cylo•1d ago•685 comments

Holding Community Space

https://supernuclear.substack.com/p/building-a-space-people-never-want
34•surprisetalk•3d ago•21 comments

Microsoft Israel chief leaves amid ethical controversy

https://en.globes.co.il/en/article-microsoft-israel-chief-leaves-amid-ethical-controversy-1001542602
124•bhouston•4h ago•119 comments