How to sequence your own DNA at home

https://bradleywoolf.com/links-1/sequencing-my-own-dna-at-home

43•bilsbie•1h ago

Comments

Aurornis•1h ago

I wish this had some discussion of the results. The earlier reports about this sensor and process were very mixed. It’s a cool process either way, but I’d like to know how usable the real world output can be.

whatever1•59m ago

What is the accuracy in this ? Aka if I run the experiment 10 times how many differences will i get? I don’t have a physical sense on what would be a good number.

myhf•36m ago

You would get a lot of differences, but the errors would cancel each other out with enough depth of coverage.

This technology's baseline accuracy is around 95% per base, so 10x reads of every segment in the sample would give >99% accuracy for each base after aligning the reads with each other.

https://en.wikipedia.org/wiki/Coverage_(genetics)

Jules-Bertholet•31m ago

> so 10x reads of every segment in the sample would give >99% accuracy for each base after aligning the reads with each other

This assumes random errors, which IIRC isn't the case for Oxford Nanopore.

Jules-Bertholet•33m ago

Oxford Nanopore unfortunately has a high error rate (3-5%) compared to other sequencing technologies. And the errors are non-random

mephux•42m ago

https://www.the-odin.com/whole-genome-sequencing-30x/

If you want it quick and cheap(er) - 599.00

drdaeman•34m ago

If it's an US-based lab, aren't they subject to CLIA with all its retention requirements?

For $7.5k+ you get a guaranteed privacy (as other comments suggest, other properties may vary, but at least the data never leaves your home).

vibrio•8m ago

I suspect there is a deep sequencing service that is non CLIA and cheap. True. they may not be trustworthy with the data. That said, there are steps here where the data is put into Claude. Do we trust that ?

bleepblap•39m ago

> This is intended to be read by AI

Fuck this

asveikau•18m ago

Yeah that's weird. The instructions are not even hard to read. I don't understand what an LLM would add to this.

SuperSixFour•15m ago

Literally left the article to come here and say this.

metalman•35m ago

I am very impressed with the, why wait? just do it now approach to the future. which while not here, IS there.

dekhn•20m ago

Nothing about this is the future. Sequencing at home will not solve any major problems. It's mainly a fun exercise to demonstrate that sequencing has been commodified.

dwa3592•22m ago

This is so cool. Thanks for doing this. The fact that we have this in a palm sized object is just crazy. Also, if/when we have a similar sized device for doing CRISPR .... umm i should stop here - it's becoming the plot of Gattaca

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How to sequence your own DNA at home

Comments

Fable turned reMarkable into Tom Riddle's diary from Harry Potter

OpenWrt One – Open Hardware Router

How to sequence your own DNA at home

CoMaps – FOSS Offline Maps

GLM 5.2 and the coming AI margin collapse

Ternlight – 7 MB embedding model that runs in browser (WASM)

NSA and IETF: Fairness

A global workspace in language models

Pruning RAG context down to what the answer actually needs

A 2048-spin bulk acoustic wave Ising machine for number partitioning and Sudoku

Small AI Models Gain Traction In places with unreliable networks

Full Writeup of the Windows GDID

Linux on the Atari Jaguar

AMD Ryzen AI Halo – $4k AI Dev Kit

Stealth robotics startup (YC S26) is hiring principal engineers (Palo Alto)

Resetting Xbox

Strata – An app that talks me out of dying outdoors

Acronym Fatigue Series Introduction: why I'm wary of acronyms

OfficeCLI: Office suite for AI agents to read and edit Microsoft Office files

AI: The ROI Runway Could Be Long Outside the Tech Sector

Craig Mod built his own Good Reads

OpenSSH 10.4/10.4p1 Released

Learning to code is still worthwhile

Evaluation order and nontermination in query languages

LLMs Are Not a Default Execution Engine

The Music of Destruction

The LLVM Compiler Infrastructure

Aluminum foil (2021)

Januscape: Guest-to-Host Escape in KVM/x86 [CVE-2026-53359]

Using precision editing to study human embryo development shows master gene