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GPT-5.6 used a prompt to close a 30-year gap in convex optimization

https://old.reddit.com/r/math/comments/1uxj3cy/after_openais_cdc_proof_announcement_gpt56_used_a/
373•mbustamanter•6h ago•218 comments

Gleam Is Now on Tangled

https://tangled.org/gleam.run/gleam
120•nerdypepper•3h ago•69 comments

The Kimi K3 Moment

https://stephen.bochinski.dev/blog/2026/07/18/the-kimi-k3-moment/
38•sbochins•1h ago•21 comments

Goodbye, and Thanks for All the Bikesheds

https://queue.acm.org/detail.cfm?id=3818307
100•Ygg2•1h ago•86 comments

If You Build It, They Will Come

https://www.benlandautaylor.com/p/if-you-build-it-they-will-come
85•barry-cotter•3h ago•29 comments

Elixir-lang.org has a new design

https://elixir-lang.org/
95•bbg2401•3h ago•60 comments

Is this the end of the once-mighty GoPro?

https://amateurphotographer.com/latest/photo-news/going-going-gone-is-this-the-end-of-the-once-mi...
142•aanet•3d ago•243 comments

Our Approach to Bioresilience: Isomorphic Labs and Google DeepMind

https://deepmind.google/blog/our-approach-to-bioresilience/
35•bookofjoe•3h ago•18 comments

Fable 5 vs. GPT-5.6 Sol on an NP-Hard Problem: Does /goal help?

https://charlesazam.com/blog/fable-5-gpt-5-6-sol-goal/
166•couAUIA•8h ago•84 comments

What's the deal with all the random weekly quota resets for agents lately?

https://minimaxir.com/2026/07/agent-quota-reset/
4•minimaxir•18m ago•0 comments

REO Trucks I4 4WD Pickup Truck Starts at $21,500

https://reotrucks.com
44•b_mc2•1h ago•43 comments

Regressive JPEGs

https://maurycyz.com/projects/bad_jpeg/
594•vitaut•16h ago•62 comments

LG monitors silently install software through Windows Update without consent

https://videocardz.com/newz/lg-monitors-silently-install-software-through-windows-update-without-...
801•baranul•9h ago•405 comments

Setting up your spare Mac for Claude Code to control, a step-by-step guide

https://ykdojo.github.io/claude-controls-mac/
97•ykev•3h ago•74 comments

Tech note: making your own V-I plots at home

https://lcamtuf.substack.com/p/tech-note-making-your-own-v-i-plots
45•zdw•23h ago•6 comments

Show HN: Q3Edit – Edit and play Quake 3 maps in the browser

https://q3edit.com
33•drdator•4h ago•8 comments

A Second-Grade Teacher Revived a Beloved Video Game

https://www.nytimes.com/2026/07/13/style/backyard-baseball-video-game-teacher.html
38•danso•5d ago•15 comments

Show HN: Get alerts for good seats at 70mm IMAX showings of The Odyssey

https://imaxxing.io/
13•andrewtorkbaker•1h ago•10 comments

What AI did to stackoverflow in a graph

https://data.stackexchange.com/stackoverflow/query/1953768#graph
300•secretslol•8h ago•348 comments

How GitHub gave every repository a durable owner

https://github.blog/security/application-security/how-github-gave-every-repository-a-durable-owner/
33•ascertain•1w ago•5 comments

GTX 1080s: Testing a Legend

https://www.lttlabs.com/articles/2026/07/15/gtx-1080s-revisiting-legends
50•LabsLucas•2d ago•18 comments

Thanks HN for 15 years of support and helping me find my life's work

766•nicholasjbs•1d ago•97 comments

The Computer at the Bottom of a Canal

https://negroniventurestudios.com/2026/07/18/the-computer-at-the-bottom-of-a-canal/
117•Kudos•10h ago•25 comments

Reviving a 15-year-old netbook with Arch Linux

https://parksb.github.io/en/article/41.html
197•parksb•4d ago•134 comments

Fake food delivery site for the dopamine

https://old.reddit.com/r/BingeEatingDisorder/comments/1uzr3ui/fake_food_delivery_site_for_the_dop...
60•guerrilla•3h ago•23 comments

The Fermi Paradox, Percolation, and Inbreeding

https://reactormag.com/the-fermi-paradox-percolation-and-inbreeding/
17•bryanrasmussen•3h ago•25 comments

EU ban on destruction of unsold clothes and shoes enters into application

https://environment.ec.europa.eu/news/ban-destruction-unsold-clothes-and-shoes-enters-application...
206•robtherobber•5h ago•193 comments

British runner Josh Kerr breaks world record for mile which stood for 27 years

https://news.sky.com/story/british-runner-josh-kerr-breaks-world-record-for-mile-which-had-stood-...
71•austinallegro•4h ago•47 comments

Qubes OS Security in the Public Record

https://arxiv.org/abs/2607.14587
64•sciences44•10h ago•9 comments

No link between acetaminophen use during pregnancy and adverse birth outcomes

https://sph.unc.edu/sph-news/no-link-between-acetaminophen-use-during-pregnancy-and-adverse-birth...
42•geox•3h ago•23 comments
Open in hackernews

No link between acetaminophen use during pregnancy and adverse birth outcomes

https://sph.unc.edu/sph-news/no-link-between-acetaminophen-use-during-pregnancy-and-adverse-birth-outcomes-study-finds/
42•geox•3h ago

Comments

eth0up•1h ago
Just for the sake of honest balance, with minimal commentary and no opinions:

Acetaminophen and dementia correlation:

https://pmc.ncbi.nlm.nih.gov/articles/PMC2877629/

https://www.sciencedirect.com/science/article/abs/pii/S01638...

Note that it's also hard on the liver. A lot fatalities due to taking after hangovers, etc: https://www.medicalnewstoday.com/articles/322813 So if you insist, maybe take some NAC.

But apparently, Ibuprofen helps counter the dementia risk:

https://www.aan.com/PressRoom/home/PressRelease/624

I am not not asserting any clever marketing here. I am merely citing public information. Noting all the above, I am confident it's perfectly safe for children and fetuses, and if posing any risk at all, applies strictly to full grown adults. No doubts about child safety have been expressed here.

estearum•1h ago
The first paper shows no evidence of any effect from Tylenol...? But yeah seems like lots of support for the ibuprofen protective effect, interestingly.
eth0up•43m ago
If you do start munching on advil; note there are rumors, by medical researchers, case reports, and more, that if you dig beneath the shiny surface to find, do show a lot of compelling data for GI damage, heart risk and other serious side-effects. And depending on how fair one wants to be with 'evidence' -- almost all wording describing NSAIDs as "protective", uses easy-to-miss but distinct qualifiers such as "potential" and other such vague 'maybe'-equivalents that alone have been used to suppress and dismiss many other...potential medicines. Sometimes, conclusive just means inspired. And sometimes ambiguity means certainty, depending on levels of inspiration involved.

Of course, one might pause for a moment to consider just how potential the alluded benefits really are with ibuprofen, and ask why doctors aren't recommending it for mental health, or as a general health product. But that might point to the peculiar fact that there is substantially more evidence suggesting risk over health benefits, and the benefits really depend on what one wants to see. There is a reason it's not marketed as a health product, but with the way it's framed, it should be, nu? I mean, potential benefits sells a lot of snake oil and lowfat yogurt. Why not advil and acetaminophen?

And by similar logic used to dismiss acetaminophen here as a health risk, eg because there's no link with autism/ADHD it's safe; why not apply the same logic to opiates? We could just say opiates do not directly cause, eg , parkinsons, or AIDS, therefore it's safe for babies. Myself, I never correlated acetaminophen with autism/ADHD, but I know it has more side-effects than listen on the bottle.

estearum•36m ago
Yeah I work in clinical trials so I'm very comfortable with all the caveats the need to be applied to correlative studies like these.

Which also answers your other question of why doctors don't recommend it: we don't actually know that it does this.

As for the rest of the ramble, you (or I) definitely don't know hardly anything that hasn't been established in clinical trials. Certainly can't just vibes-based assess a label and its completeness. It's really, really hard to know things.

The precise wording as far as safety is: "we have no substantive or high-quality evidence that the drug is unsafe."

greggsy•1h ago
The liver toxicity is well known, and overdose is not uncommon.
lokar•1h ago
A better policy fix would be to remove it from multi-drug products. Require it always be the only active ingredient.
mmooss•49m ago
> overdose is not uncommon

Anecdotally, I hear about it far more in Internet comments like the parent than elsewhere. How common is it?

ctoa•59m ago
"A lot fatalities due to taking after hangovers" no, that's not how acetaminophen fatalities happen. In fact, the article you cited specifically mentions "there is no scientific evidence that people with AUD (alcohol use disorder) who take the recommended dose of acetaminophen increase their risk of liver damage."

Fatalities happen basically from: product stacking combination medicines people don't realize contain acetaminophen and/or multi-day accumulation exceeding max daily limit over multiple days.

Chronic drinkers have impaired acetaminophen processing so they can't handle otherwise safe doses, but fatalities still typically occur in multi-day accumulation scenarios. Their safe daily max is ~half that of a non drinker.

The effects of one round of acute drinking don't impair the liver in the same way. People are not dropping dead because they took a normal dose of acetaminophen for a hangover. Not that I'm recommending you start doing it, but it is a myth.

redwall_hp•40m ago
> Fatalities happen basically from: product stacking combination medicines people don't realize contain acetaminophen and/or multi-day accumulation exceeding max daily limit over multiple days.

I find it obnoxious that NyQuil has taken over as the default brand people grab for cough syrup, for that reason. It has acetaminophen, while Robitussin or such have the other active ingredients without that risk.

The typical person doesn't read and understand active ingredients, and it's lucky if they even check dosage instructions.

ctoa•26m ago
I absolutely think we should ban acetaminophen in otc combo meds. There was a big drop in hospitalizations when they dropped the max allowed dose in prescription drugs like Vicodin, there's no reason these otc things like NyQuil need to exist at all.
phendrenad2•48m ago
This article is about "how early a child is born or a child’s weight at birth". I don't know why we're talking about other possible negatives of Acetaminophen. Seems off-topic to me.
DANmode•1h ago
Now do the study in mutated (MTHR, MTHFR, COMT, others, some combination of them) sample populations.
estearum•1h ago
Why?
DANmode•50m ago
Because those mutations change detox efficiencies.

Not sure I understand the question!

qsera•1h ago
clean chit!
tootie•46m ago
And yet I still see MAHA defenders even on HN.
anonymousiam•45m ago
This paper says there are no adverse effects to the mother, but it does not mention possible adverse effects to the child beyond "birth health" and does not address the recent controversy about a possible link to autism.
dofm•26m ago
Why would it need to? There is no medical controversy.

There’s only a weak and now discounted statistical association that was seized upon by two disgraceful anti-science politicians to create a political controversy.

ourmandave•58s ago
I can't figure it out. What is the actual reason they knowingly LIED about it?

Some personal grievance against Tylenol brand?

More graft from a competitor?

Appease their conspiracy loving dumbass base?

Destroy the scientific reputation of the US?

Trump is actually that fucking stupid?

All of the above?

eth0up
•
22m ago
Because we couldn't possibly modify

"we have no substantive or high-quality evidence that the drug is unsafe." - (damn all the research showing it is)

--to

"we have no substantive or high-quality evidence that the drug is safe." - (damn all the research suggesting it isn't)

Well, that's as good a green light for an ad campaign as one could ask for. "we don't actually know that it does this." ain't never stopped a motivated pharmaceutical rep before. You have my official endorsement for feeding advil and acetaminophen to all. And protection from dementia is just what America needs. !Win / !Win

Maybe restless leg and depression too! And don't tell me fetuses don't get depressed there in that dark womb. We know damn well they get restless.

estearum•19m ago
Drugs are approved for the specific uses based on extremely high-quality evidence. That evidence balances the benefits against the detectable downsides/costs/side-effects. Those downsides are also on the label.

That's almost entirely generated by the highest quality evidence generation system we could possibly have, which is RCTs. And no, pharma reps actually aren't allowed to encourage (or even talk about) off-label uses of drugs.

I get the sense that you don't know much about this space.