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Computational chemistry, Locally? My rant on SSH

https://chillphysicsenjoyer.substack.com/p/computational-chemistry-locally
11•crescit_eundo•2d ago

Comments

iyihz•35m ago
i think instead of trying to do more of the work locally, it might be worth considering trying to work more frictionlessly within the cluster environment instead? e.g. using claude to script visualizing the results and transferring them to your local environment for convenient inspection, or even designing a local GUI for running the jobs and inspecting the results?

it doesn't handle the VPN/2FA friction I guess, but I'd think unless most work can be done locally it would be better to invest in making cluster work more convenient

fxwin•31m ago
OP is not ready for corporate environments if "VPN + ssh + 2FA" already "feels like too much" lol

I also wonder how they didn't come across X Forwarding at all? When i used a remote machine for my thesis that was one of the first things i set up, just so i could do small experiments on GPU and look at results more easily.

Basically every issue they seem to have is solved by using VSCode + Remote development (Transferring files, Customizing hotkeys, looking at outputs)

>And as for compute, I also realised that there are many small tasks that can actually be run on my machine

Yes, if you have a $3000 Computer, you can do many things that other people would need to use remote compute for. Depending on the "Cluster" they are talking about, the mac might even have better specs lol

_notreallyme_•24m ago
Most issues can be solved by RTFM. They don't seem to have ever considered that...
NullifyNAN•26m ago
It seems like you’re so close but yet so far. It’s interesting that you concluded that Claude makes it easier to run tasks locally but did not conclude that claude makes it easier to use the cluster. Feels we’re in need of a part 2 where you use CC to automate all of the mundane cluster work.

Also just a hot tip, if you’re able to keep any always-only PC on a university subnet (your PI should have some form of a server) you can use tailscale as a jump proxy and bypass the whole VPN dance.

smitty1e•19m ago
Living this dream with the CI/CD pipeline deploying to a cloud system.

It's really, really hard to shrink the problem and troubleshoot with large, opaque, containerized chunks of functionality and services.

Can I just connect to a DB in a terminal and run some SQL to figure out the problem?

Why, no: no, you cannot.

Flux 3 X Mimic: The Next Generation of Video-Action Models

https://bfl.ai/blog/flux-3-mimic
96•kensai•2h ago•8 comments

Flux 3

https://bfl.ai/blog/flux-3
346•ThouYS•5h ago•90 comments

It's getting harder to focus every day

https://glyphack.com/attention/
134•peykar•3h ago•67 comments

Writing by hand is good for your brain

https://nealstephenson.substack.com/p/writing-by-hand-is-good-for-your
1344•dwwoelfel•21h ago•613 comments

Startup founders urge U.S. government not to shut off Chinese open weight AI

https://www.politico.com/news/2026/07/22/startup-founders-urge-trump-not-to-shut-off-chinese-open...
975•theanonymousone•20h ago•793 comments

Buz – A fork of Bun using modern Zig, with sub-1s incremental builds

https://ziggit.dev/t/buz-a-drop-in-replacement-for-bun-using-modern-zig-with-sub-1s-incremental-b...
27•kristoff_it•2h ago•5 comments

Claude Cookbook

https://platform.claude.com/cookbook/
99•saikatsg•6h ago•45 comments

The Beam Engine

https://glinscott.github.io/beam-engine/
413•glinscott•1d ago•80 comments

Computational chemistry, Locally? My rant on SSH

https://chillphysicsenjoyer.substack.com/p/computational-chemistry-locally
12•crescit_eundo•2d ago•5 comments

Show HN: Echo – Fable-level results at 1/3 the cost using open-weight models

397•adam_rida•16h ago•191 comments

The Book Prize Index

https://book-prize-index.vercel.app
14•Luc•3h ago•1 comments

The day Steve Jobs dissed me in a keynote (2010)

https://sive.rs/itunes
84•downbad_•2h ago•19 comments

Game of Trees – Git-based version control from OpenBSD folks

https://www.gameoftrees.org/
4•gregnavis•1h ago•0 comments

What happened to TheNumbers.com

https://stephenfollows.com/p/what-just-happened-to-thenumberscom-should-worry-us-all
386•nickthegreek•18h ago•180 comments

AMD's Instinct MI455X: Aiming for the Sun

https://chipsandcheese.com/p/amds-instinct-mi455x-aiming-for-the
22•ingve•4h ago•5 comments

Why Software Factories Fail (or: harness engineering is not enough)

https://github.com/humanlayer/advanced-context-engineering-for-coding-agents/blob/main/wsff.md
336•dhorthy•20h ago•241 comments

What else do people draw on gradient.horse?

https://rybakov.com/blog/what_else_do_people_draw_on_gradient-copy.horse/
144•spython•5d ago•27 comments

I regret migrating to Codeberg

https://xn--gckvb8fzb.com/i-regret-migrating-to-codeberg/
357•boramalper•21h ago•250 comments

The PImpl idiom and the C++26 std:indirect type

https://mariusbancila.ro/blog/2026/07/23/the-pimpl-idiom-and-the-cpp26-stdindirect-type/
54•signa11•4h ago•50 comments

Learn OpenGL, extensive tutorial resource for learning Modern OpenGL

https://learnopengl.com/
256•ibobev•20h ago•134 comments

Hetzner is working on LLM Inference

https://sliplane.io/blog/hetzner-inference
25•jonas_scholz•2h ago•11 comments

Why Sony can't bring back its classic Walkman models

https://obsoletesony.substack.com/p/why-sony-cant-bring-back-classic-walkman
145•speckx•17h ago•159 comments

DARPA, U.S. Air Force fly AI-controlled F-16

https://www.darpa.mil/news/2026/darpa-us-air-force-fly-ai-controlled-f-16
255•r2sk5t•21h ago•282 comments

Software rendering in 500 lines of bare C++

https://haqr.eu/tinyrenderer/
286•mpweiher•21h ago•65 comments

Nothing works and everyone is euphoric

https://ptrchm.com/posts/nothing-works-and-everyone-is-euphoric/
106•pchm•2h ago•100 comments

Show HN: Palmier Pro – Open-source macOS video editor built for AI

https://github.com/palmier-io/palmier-pro
170•harrisontin•20h ago•26 comments

Quickly rewrite Git repository history

https://github.com/newren/git-filter-repo
52•modinfo•3d ago•4 comments

Projects every RC live races and results

https://rc-replay.dev/lr/vmrc/r/6912053
16•apokly•3d ago•0 comments

98.css

https://jdan.github.io/98.css/#status-bar
485•lopespm•13h ago•110 comments

Fields Medals 2026

https://www.mathunion.org/imu-awards/fields-medal/fields-medals-2026
192•nill0•21h ago•95 comments