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New HIV vaccine shows unprecedented success in preclinical study

https://www.lji.org/news-events/news/post/new-hiv-vaccine-shows-unprecedented-success-in-preclinical-study/
104•codebyaditya•1h ago

Comments

short_sells_poo•48m ago
OK this sounds fantastic, but is it going to be another case of an expert dropping in on this thread and going "Ah, 100s of these come out every month. It's promising but nowhere near human trials yet."
RGS1811•46m ago
While HIV vaccine research is an exciting field, it's worth pointing out that halting HIV transmission is, practically speaking, a solved problem with oral and injectable reverse transcriptase inhibitors. The ongoing loss of life and health due to HIV could be stopped if we cared enough to invest resources in wide-scale PrEP availability and public health education. Waiting for an HIV vaccine is the domain equivalent of hoping fusion power will solve our energy needs. Other solutions exist already; we just have to use them.
XorNot•42m ago
Who's waiting? The problem is the populations we need to distribute it to can least afford it.

The reason we want a vaccine is because there's a huge logistics difference between a twice yearly injection and the real magic of something more like an MMR shot where one dose is usually effective for life.

Varelion•42m ago
Project 2025 vehemently goes against of it.
RajT88•35m ago
Long history of not wanting to address the epidemic:

https://en.wikipedia.org/wiki/Ronald_Reagan_and_AIDS

greggsy•39m ago
Isn’t prep more like a prophylactic, as opposed to a a vaccine?

I’m more familiar with malaria, where the preventative medicines are currently more effective than the vaccines.

RGS1811•36m ago
The analogy to malaria is pretty on point. Pre-Exposure Prophylaxis (PrEP) is, you nailed it, prophylactic. It's not as good as a vaccine would be, and it's not as cheap as a one-and-done shot, but we've gotten to the point where you can get one shot every six months (lenacapavir) and, it's 99%+ effective at preventing infection. And, much like with malaria, the prophylaxis works— there is currently no HIV vaccine that reliably prevents infection.
nerdjon•34m ago
Cost and compliance are still 2 major factors that have not been solved.

We also have education and stigma. While within the LGBT community it is far more common to be open about status and taking prep and doxy (far from perfect though), it still feels like outside of that the conversations are not happening as much as they should.

Throw in doctors that are not being proactive about the conversation.

Right now it seems like having prep and doxy is largely considered only if you are engaged in "risky" behavior (not saying that in a judgmental way to be clear), instead of just being sexually active and protecting yourself. Money and investment alone won't fix that, that is a societal shift around how we talk about sex.

That is also before we get into the cost issues in many other countries just for those that do need it.

bluGill•2m ago
PReP has some side effects. While they are rare, they are things you need to be aware of. If you are not doing risky sex it isn't for you.

Most people want to believe they are in a monogamous relationship and thus not having risky sex - even though they are the one cheating. Either PReP needs to be more common, are people need to stop their risky sex activities (that they are not even admitting to).

abirch•1m ago
Compliance is the big thing.

Vaccines are the "an ounce of prevention is worth a pound of cure"

ChrisRR•25m ago
There's still a huge difference between a one off injection and lifelong tablets.
mathgeek•20m ago
From a convenience factor, sure, but both effectively turn a death sentence into a solved problem. I believe GP was pointing out that we should prioritize funding for the existing solution until the more convenient one is available.
niceguy1827•20m ago
This is the wrong take. You are basically arguing that if we have one solution, why bother having a second one?
evilfred•19m ago
prep is great but i would really rather take a one-time vaccine than be expected to take an expensive pill forever that could mess up my liver
cogman10•16m ago
It's a solved problem if you are someone that knows you'll be exposed to HIV in the very near future and you have the money and wherewithal to purchase PrEP before that event (and you can plan the event 7 days out).

The power of a vaccine is you can give it to adults and kids before they are sexually active and protect them, potentially, for the rest of their lives.

I'd also be curious to know if the combination of ART + the vaccine might cure someone of HIV. Which is also a pretty big deal.

compass_copium•4m ago
This is completely inaccurate. There is PrEP that requires dosing two times a year. You can also get PEP if you engage in a risky activity without PrEP.
smcg•16m ago
Those on prep would welcome a vaccine, it would be a significant improvement. I agree that this is no reason to take the foot off the gas with prep availability, we need more ASAP.
gadders•15m ago
Is it not available in pharmacies?
est31•12m ago
For rich people (meaning the ~3 billion people that have some sort of access to medical infrastructure), it is a solved problem, but there are quite many people without any access to it. Even for those "solved problem" people, taking a pill every day to be protected is inconvenient. They might not take it every day, etc.

Also, even if it were a solved problem, the methodologies developed here can probably help with other viruses too in the future. This has already happened with the antivirals originally developed for HIV.

compass_copium•2m ago
Again, inaccurate. You can get a PrEP shot twice a year now.

Access is a valid point. Perhaps the money being used to fund a superfluous vaccine should be used to fund access to PrEP in the Third World.

AndrewDucker•43m ago
Tested on rhesus macaques. Worked well for 44% of them.

It's a positive step, but still a fair way off for humans.

nerdjon•40m ago
I have to admit that given how many times we have been here, I struggle with being excited about any news about a HIV vaccine until we see results from humans. Just way too many times of hope.

That being said, I don't understand enough to parse this very buzzword heavy release. Is this fundamentally different than the every 6 month vaccine we have now and is a more traditional vaccine or is it just continuing on that trend?

noname120•3m ago
Long-acting antiretroviral injection ≠ vaccine
khalic•34m ago
Phase I trials happening now. Godspeed to them. It’s where most HIV vaccines die
iandanforth•15m ago
The most interesting point of the article for me is that this vaccine appears to be a series of shots which act as a curriculum for the immune system. Each one slightly different and targeting a different stage of B-cell development. I've never thought of vaccine series working like that, so it was a new and impressive idea.
api•8m ago
All vaccines are training data for the immune system, which is a learning machine whose operation is a little bit like a genetic algorithm. It generates and sieves variation using a vocabulary of pre-encoded building blocks to fit the targets it's presented with.

It's an incredible system, and a product of probably a billion years of evolution since the first multicellular organisms had to protect themselves from infection.

okzgn•5m ago
Congratulations, hope the vaccine shows the same highly positive results in humans as it did in the primates on which it was tested.

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491•krembo•6h ago•92 comments

New HIV vaccine shows unprecedented success in preclinical study

https://www.lji.org/news-events/news/post/new-hiv-vaccine-shows-unprecedented-success-in-preclini...
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