I mean, we’re talking about real physical things, not first principles thought experiments here. Thus, they have limits imposed by physics and biology. Limits on transmission rate, lethality, particle size, evolutionary change rates, and so on. All of these interact and define a design space that nature has been searching for at unimaginable scale for as long as humans have existed. And yet here we are! Seems like “wiping humanity” might be really hard, perhaps impossible for a virus.

Perhaps I’m being uncharitable or insufficiently creative, but these people strike me as deeply unserious in their engagement with the actually real physical world of biology.

EDIT: Also, in this world, couldn’t an AI just “one shot” a vaccine and an effective treatment?