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Show HN: Mermaid Formatter – CLI and library to auto-format Mermaid diagrams

https://github.com/chenyanchen/mermaid-formatter
1•astm•1m ago•0 comments

RFCs vs. READMEs: The Evolution of Protocols

https://h3manth.com/scribe/rfcs-vs-readmes/
1•init0•8m ago•1 comments

Kanchipuram Saris and Thinking Machines

https://altermag.com/articles/kanchipuram-saris-and-thinking-machines
1•trojanalert•8m ago•0 comments

Chinese chemical supplier causes global baby formula recall

https://www.reuters.com/business/healthcare-pharmaceuticals/nestle-widens-french-infant-formula-r...
1•fkdk•11m ago•0 comments

I've used AI to write 100% of my code for a year as an engineer

https://old.reddit.com/r/ClaudeCode/comments/1qxvobt/ive_used_ai_to_write_100_of_my_code_for_1_ye...
1•ukuina•13m ago•1 comments

Looking for 4 Autistic Co-Founders for AI Startup (Equity-Based)

1•au-ai-aisl•23m ago•1 comments

AI-native capabilities, a new API Catalog, and updated plans and pricing

https://blog.postman.com/new-capabilities-march-2026/
1•thunderbong•24m ago•0 comments

What changed in tech from 2010 to 2020?

https://www.tedsanders.com/what-changed-in-tech-from-2010-to-2020/
2•endorphine•29m ago•0 comments

From Human Ergonomics to Agent Ergonomics

https://wesmckinney.com/blog/agent-ergonomics/
1•Anon84•32m ago•0 comments

Advanced Inertial Reference Sphere

https://en.wikipedia.org/wiki/Advanced_Inertial_Reference_Sphere
1•cyanf•34m ago•0 comments

Toyota Developing a Console-Grade, Open-Source Game Engine with Flutter and Dart

https://www.phoronix.com/news/Fluorite-Toyota-Game-Engine
1•computer23•36m ago•0 comments

Typing for Love or Money: The Hidden Labor Behind Modern Literary Masterpieces

https://publicdomainreview.org/essay/typing-for-love-or-money/
1•prismatic•37m ago•0 comments

Show HN: A longitudinal health record built from fragmented medical data

https://myaether.live
1•takmak007•40m ago•0 comments

CoreWeave's $30B Bet on GPU Market Infrastructure

https://davefriedman.substack.com/p/coreweaves-30-billion-bet-on-gpu
1•gmays•51m ago•0 comments

Creating and Hosting a Static Website on Cloudflare for Free

https://benjaminsmallwood.com/blog/creating-and-hosting-a-static-website-on-cloudflare-for-free/
1•bensmallwood•56m ago•1 comments

"The Stanford scam proves America is becoming a nation of grifters"

https://www.thetimes.com/us/news-today/article/students-stanford-grifters-ivy-league-w2g5z768z
3•cwwc•1h ago•0 comments

Elon Musk on Space GPUs, AI, Optimus, and His Manufacturing Method

https://cheekypint.substack.com/p/elon-musk-on-space-gpus-ai-optimus
2•simonebrunozzi•1h ago•0 comments

X (Twitter) is back with a new X API Pay-Per-Use model

https://developer.x.com/
3•eeko_systems•1h ago•0 comments

Zlob.h 100% POSIX and glibc compatible globbing lib that is faste and better

https://github.com/dmtrKovalenko/zlob
3•neogoose•1h ago•1 comments

Show HN: Deterministic signal triangulation using a fixed .72% variance constant

https://github.com/mabrucker85-prog/Project_Lance_Core
2•mav5431•1h ago•1 comments

Scientists Discover Levitating Time Crystals You Can Hold, Defy Newton’s 3rd Law

https://phys.org/news/2026-02-scientists-levitating-crystals.html
3•sizzle•1h ago•0 comments

When Michelangelo Met Titian

https://www.wsj.com/arts-culture/books/michelangelo-titian-review-the-renaissances-odd-couple-e34...
1•keiferski•1h ago•0 comments

Solving NYT Pips with DLX

https://github.com/DonoG/NYTPips4Processing
1•impossiblecode•1h ago•1 comments

Baldur's Gate to be turned into TV series – without the game's developers

https://www.bbc.com/news/articles/c24g457y534o
3•vunderba•1h ago•0 comments

Interview with 'Just use a VPS' bro (OpenClaw version) [video]

https://www.youtube.com/watch?v=40SnEd1RWUU
2•dangtony98•1h ago•0 comments

EchoJEPA: Latent Predictive Foundation Model for Echocardiography

https://github.com/bowang-lab/EchoJEPA
1•euvin•1h ago•0 comments

Disablling Go Telemetry

https://go.dev/doc/telemetry
1•1vuio0pswjnm7•1h ago•0 comments

Effective Nihilism

https://www.effectivenihilism.org/
1•abetusk•1h ago•1 comments

The UK government didn't want you to see this report on ecosystem collapse

https://www.theguardian.com/commentisfree/2026/jan/27/uk-government-report-ecosystem-collapse-foi...
5•pabs3•1h ago•0 comments

No 10 blocks report on impact of rainforest collapse on food prices

https://www.thetimes.com/uk/environment/article/no-10-blocks-report-on-impact-of-rainforest-colla...
3•pabs3•1h ago•0 comments
Open in hackernews

Researchers find a way to make the HIV virus visible within white blood cells

https://www.theguardian.com/global-development/2025/jun/05/breakthrough-in-search-for-hiv-cure-leaves-researchers-overwhelmed
216•colinprince•8mo ago

Comments

w10-1•8mo ago
Here's the paper: https://www.nature.com/articles/s41467-025-60001-2

To be clear: they deliver the HIV TAT protein which activates latent cells to transcribe HIV (ultimately possibly producing viable HIV virions).

Activating-to-kill has been pursued with other agents, but none have proven effective at depleting the reservoir. (The latent reservoir requires HIV anti-retroviral therapy to be lifelong, making one of the top three most expensive diseases in the US).

This may be more of a proof for the method, of encapsulating a fragile mRNA in a protective lipid layer, but one which will be incorporated into cells. I'd expect it to be used outside attempts to cure HIV (having consumed some HIV funding).

sirspacey•8mo ago
thank you for this, very interesting
_Microft•8mo ago
> This may be more of a proof for the method, of encapsulating a fragile mRNA in a protective lipid layer, but one which will be incorporated into cells. I'd expect it to be used outside attempts to cure HIV (having consumed some HIV funding).

What does that mean? (mRNA encapsulated in a lipid nanoparticle entering cells is exactly how the COVID vaccines of BioNTech and Moderna work)

rusk•8mo ago
Trojan Horse
ampdepolymerase•8mo ago
The phospholipid micelles are non-trivial (trade secret) to make and it's the major reason why African nations and other countries have not been able to successfully create mRNA vaccines at scale.

A cell is a bundle of proteins wrapped in a membrane that's sort of an oil drop (or as another comment said, a fat bubble). In biology it's called a phospholipid bilayer. Fun fact you can actually "merge" cells together with the help of certain viruses. Drug delivery usually involves moving molecules though this phospholipid bilayer which involves all sorts of tricks. There are pores and receptors on the membrane that can selectively bind to different biochemical molecules and proteins. A good chunk of research in bioinformatics, chemoinformatics, quantum computing is focusing on simulating protein binding dynamics and protein-protein interactions on various levels so we can design drugs that can bind to the receptors we want. (Alphafold made this a lot easier to figure out how to go from a sequence of genetic material to a specific protein shape) A RNA vaccine is kinda like a virus in that it has to be taken into a so the cellular machinery (ribosomes) can build the protein that it codes for. So having a micelle (or nanoparticle, whatever you want to call it) that can get absorbed and merged into the cell that you are targeting specifically is a Big Deal.

bijection•8mo ago
The linked article covers this - the main innovation is neither the HIV activation treatment nor the general mRNA-wrapped-in-lipids (LNP) delivery mechanism. Instead, it's a new form of LNP which works on specific white blood cells that were hard to target before.

  It was “previously thought impossible” to deliver mRNA to the type of white
  blood cell that is home to HIV, said Dr Paula Cevaal, research fellow at the
  Doherty Institute and co-first author of the study, because those cells did
  not take up the fat bubbles, or lipid nanoparticles (LNPs), used to carry it.

  The team have developed a new type of LNP that those cells will accept, known
  as LNP X. She said: “Our hope is that this new nanoparticle design could be a
  new pathway to an HIV cure.”
dyauspitr•8mo ago
If you can activate the latent cells all at once, in theory your immune system can do the rest.
ben_w•8mo ago
"If" is the hard part of many things.
bawolff•8mo ago
Interesting. I wonder if this would be applicable to other viruses that hide dormant like shingles or herpes.
hwillis•8mo ago
Unfortunately no, which is a real shame because herpesviruses like EBV are harmful and practically unavoidable. This research is specific to delivering mRNA to white blood cells.

Herpesvirus latency is really complicated, more so than HIV. It hides in more tissues and particularly in nerves, which have some degree (debated) of immune privilege. Every type has different latency. Most types have multiple, very different methods of staying latent and stay more latent than HIV. We understand some of those methods, partially understand many of them, and still don't know a lot about others. A latent infection will probably still remain if too few of these pathways are activated at once.

vikramkr•8mo ago
Always hard to tell what and where specifically the impacts of any research will be. Looking at how they discuss the creating of this lnp formulation in the paper:

> We therefore modified the lipid composition of the LNP to enhance potency. First, the ionisable lipid DLin-MC3-DMA (MC3) was replaced with SM-102, an ionisable lipid previously shown to lead to greater cytosolic mRNA delivery through enhanced endosomal escape [30]. Second, the SM-102-LNPs were further modified using ß-sitosterol, a naturally-occurring cholesterol analogue associated with enhanced mRNA delivery [31], to create a formulation referred to as LNP X (Fig. 1b).

[30]: https://pubmed.ncbi.nlm.nih.gov/29653760/

[31]: https://pubmed.ncbi.nlm.nih.gov/32080183/

Neither of those papers they cited were focused on HIV/T cells specifically. Maybe this will have no applications, or applications in HIV only, or be generally useful for hard to transfect cells, or be bad for HIV for some unforseen reason but useful elsewhere, or be a dead end, you never know. But yeah maybe if folks run into similar challenges for approaches to dealing with those viruses, maybe there's something from this work that could help them, who knows?

istjohn•8mo ago
> Prof Tomáš Hanke of the Jenner Institute, University of Oxford, disputed the idea that getting RNA into white blood cells had been a significant challenge. He said the hope that all cells in the body where HIV was hiding could be reached in this way was “merely a dream”.
breppp•8mo ago
https://archive.md/Atn11
user____name•8mo ago
Another breakthrough earlier last month: https://www.nature.com/articles/s41467-025-59398-7
blindriver•8mo ago
Pharma companies aren’t incentivized to cure HIV. Gilead found a cure for Hepatitis C but instead of being praised for it, it was derided by Wall Street because the limited financial value. I certainly hope a more honorable company will find a cure instead of a monthly treatment like Ozempic, which is a Wall Street darling because it’s expensive and monthly.
t-writescode•8mo ago
Human Beings are incentivized to cure HIV. Real people are experiencing real pain and problem to the tune of millions of persons a year. It is among the most stigmatized long-term illnesses on the planet.

Maybe BigCo Evil Pharma isn't "incentivized" to cure HIV; but hundreds of universities including those outside the United States, are. The US does not hold a monopoly on medical advancement.

HIV is *hard* to cure. That's why it's not been cured yet.

pomtato•8mo ago
> Human Beings are incentivized to cure

i'm not so sure, insulin for diabetes is a solved problem yet it's costs hundreds of $ all because scumy of pharma corps(looking at you Eli Lily) keep renewing the patent using legal loopholes.

kgwxd•8mo ago
...in the US.
rzz3•8mo ago
Watch Excision Biotheraputics. I almost guarantee it’ll get bought and killed.
adrr•8mo ago
Gilead charges $85k for Harvoni. There's also alternative drugs from different manufacturers because there still lots of money to made. Treatments you're constrained by the duration of the patent thats need to be filed before trials. You're looking at a max of 14 years. Ozempic runs out 2032 but there are already alternative drugs.
geraneum•8mo ago
> a more honorable company

This is sad…

candiddevmike•8mo ago
Thankfully these folks are Australian and have socialized medicine where they're incentivized to fix the underlying condition instead of treating the symptoms
hackernoops•8mo ago
Positive development.
kylehotchkiss•8mo ago
Macrophage targeted mRNA. Wonderful.

Now do TB & leprosy.

meindnoch•8mo ago
Leprosy is non-existent in the developed world, and can be cured with antibiotics.
jitl•8mo ago
True that it’s preventable if caught early enough in infection. However the nerve damage caused by the leprosy bacteria is much harder to treat and continues the harm even after antibiotic treatment.
kylehotchkiss•8mo ago
The developed world is not the only place medicine matters, and the treatment course is months of antibiotics, which not adhering to can lead to antibiotic resistance. So treatment paths that can more deeply/directly eliminate the bacteria without that duration is a worthwhile research target.