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CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

https://innovativegenomics.org/news/crispr-technique-selectively-shreds-cancer-cells/
492•gmays•5h ago•133 comments

I Am Not a Reverse Centaur

https://blog.miguelgrinberg.com/post/i-am-not-a-reverse-centaur
171•ibobev•2h ago•118 comments

Malware developers added nuclear and biological weapons text to to their spyware

https://twitter.com/jsrailton/status/2064661778978533571
183•marc__1•1d ago•118 comments

How to setup a local coding agent on macOS

https://ikyle.me/blog/2026/how-to-setup-a-local-coding-agent-on-macos
133•kkm•3h ago•45 comments

Pirates, a naval warfare game inspired by Sid Meier's Pirates

https://piwodlaiwo.github.io/pirates/
114•iweczek•3h ago•43 comments

Slightly reducing the sloppiness of AI generated front end

https://envs.net/~volpe/blog/posts/reduce-slop.html
135•FergusArgyll•6h ago•94 comments

Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents

https://bitboard.work/
24•arcb•3h ago•9 comments

A PDF that changes based on how its read

https://sgaud.com/texts/pdf
93•SarthakGaud•4h ago•51 comments

Where Did Earth Get Its Oceans? Maybe It Made Them Itself

https://www.quantamagazine.org/where-did-earth-get-its-oceans-maybe-it-made-them-itself-20260612/
84•ibobev•5h ago•50 comments

Introduction to UEFI HTTP(s) Boot with QEMU/OVMF

https://blog.yadutaf.fr/2026/06/12/introduction-to-uefi-https-boot-qemu-ovmf/
51•jtlebigot•5h ago•14 comments

A dumpster arrived behind my university's library

https://yalereview.org/article/sheila-liming-the-end-of-books
138•mooreds•6h ago•116 comments

There Is Life Before Main in Rust

https://grack.com/blog/2026/06/11/life-before-main/
49•mmastrac•1d ago•13 comments

Cosmodial Sky Atlas

https://killedbyapixel.github.io/Cosmodial/
17•memalign•2h ago•1 comments

"Don't You Just Upload It to ChatGPT?"

https://correresmidestino.com/dont-you-just-upload-it-to-chatgpt/
153•speckx•2h ago•130 comments

Law Enforcement's "Warrior" Problem (2015)

https://harvardlawreview.org/forum/vol-128/law-enforcements-warrior-problem/
67•bookofjoe•3h ago•49 comments

Maxproof

https://arxiv.org/abs/2606.13473
119•ilreb•8h ago•10 comments

If you are asking for human attention, demonstrate human effort

https://tombedor.dev/human-attention-and-human-effort/
1421•jjfoooo4•21h ago•446 comments

Show HN: StackScope – I crawled over 40k indie launches to see what they ship

https://stackscope.dev/
34•datafreak_•5h ago•9 comments

Hazel (YC W24) Is Hiring a Full Stack Engineer

https://www.ycombinator.com/companies/hazel-2/jobs/3epPWgu-full-stack-engineer-ts-sci
1•augustschen•7h ago

WASI 0.3

https://bytecodealliance.org/articles/WASI-0.3
206•mavdol04•6h ago•82 comments

A Call to Action: Stop the FCC's KYC Regime

https://blog.lopp.net/call-to-action-stop-the-fcc-kyc-regime/
288•FergusArgyll•6h ago•189 comments

Looking Forward to Postgres 19: It's About Time

https://www.pgedge.com/blog/looking-forward-to-postgres-19-its-about-time
98•xngbuilds•4h ago•30 comments

Encrypted Spaces An architecture for collaborative applications

https://encryptedspaces.org/
52•_____k•8h ago•5 comments

A jacket that harvests drinking water from the air

https://news.utexas.edu/2026/06/11/this-jacket-pulls-drinking-water-from-thin-air/
153•ilreb•21h ago•96 comments

New privacy frontier: Europe eyes crackdown on smart glasses

https://www.politico.com/www.politico.eu/article/new-privacy-frontier-europe-eyes-crackdown-smart...
71•1vuio0pswjnm7•4h ago•55 comments

Kimi K2.7-Code: open-source coding model with better token efficiency

https://huggingface.co/moonshotai/Kimi-K2.7-Code
374•nekofneko•10h ago•199 comments

Nobody ever gets credit for fixing problems that never happened (2001) [pdf]

https://web.mit.edu/nelsonr/www/Repenning=Sterman_CMR_su01_.pdf
704•sam_bristow•20h ago•238 comments

You can power on a Mac remotely

https://www.jeffgeerling.com/blog/2026/power-on-your-mac-remotely/
18•speckx•5h ago•8 comments

Show HN: Script to bulk delete Claude chats from the web UI

https://github.com/MatteoLeonesi/bulk-delete-claude-chat
47•ML0037•5h ago•17 comments

Vinyl succumbs to Loudness War: more than just collateral damage (2025)

https://magicvinyldigital.net/2025/04/27/vinyl-succumbs-to-loudness-war-more-than-just-collateral...
142•sneela•6d ago•216 comments
Open in hackernews

Elliptical Python Programming

https://susam.net/elliptical-python-programming.html
184•sebg•1y ago

Comments

benob•1y ago
TIL that in python, 1--2==3
seplox•1y ago
It's not a python thing. 1-(-2), distribute the negative.
qsort•1y ago
In most C-like languages that would be a syntax error. E.g. in C and C++ as a rule you tokenize "greedily", "1--2" would be tokenized as "1", "unary decrement operator", "2", which is illegal because you're trying to decerment an rvalue.

Python doesn't have "--", which allows the tokenizer to do something else.

nyrikki•1y ago
In C, that is really because Unary minus (negation) has precedence over binary operations.

    +a - b; // equivalent to (+a) - b, NOT +(a - b)
    -c + d; // equivalent to (-c) + d, NOT -(c + d)

https://en.cppreference.com/w/cpp/language/operator_arithmet...

    +-e; // equivalent to +(-e), the unary + is a no-op if “e” is a built-in type
     // because any possible promotion is performed during negation already
The same doesn't apply to, !! Which is applied as iterated binary operations (IIRC)

I am pretty sure the decriment operator came around well after that quirk was established.

seanhunter•1y ago
Peter van der Linden’s book “Expert C Programming” (which is awesome btw) says that one of them (Kernighan, Richie or maybe Ken Thompson I forget) realised early on that the c compiler had the wrong operator precedence for bit twiddling and unary and boolean operators but “at that stage we had a few thousand lines of C code and thought it would be too disruptive to change it”
j2kun•1y ago
Also worth noting that `1 - -2` works and produces 3 in C because the space breaks the operator.
plus•1y ago
For those who are curious, `...` is a placeholder value in Python called Ellipsis. I don't believe it serves any real purpose other than being a placeholder. But it is an object and it implements `__eq__`, and is considered equal to itself. So `...==...` evaluates to `True`. When you prefix a `True` with `-`, it is interpreted as a prefix negation operator and implicitly converts the `True` to a `1`, so `-(...==...)` is equal to `-1`. Then, you add another prefix `-` to turn the `-1` back into `1`.

`--(...==...)--(...==...)` evaluates to `2` because the first block evaluates to 1, as previously mentioned, and then the next `-` is interpreted as an infix subtraction operator. The second `-(...==...)` evaluates to `-1`, so you get `1 - -1` or `2`.

When chaining multiple together, you can leave off the initial `--`, because booleans will be implicitly converted to integers if inserted into an arithmetic expression, e.g. `True - -1` -> `1 - -1` -> `2`.

> There should be one-- and preferably only one --obvious way to do it.

This article is obviously completely tongue-in-cheek, but I feel the need to point out that this sentence is not meant to be a complete inversion of the Perl philosophy of TIMTOWTDI. The word "obvious" is crucial here - there can be more than one way, but ideally only one of the ways is obvious.

pletnes•1y ago
Numpy actively uses … to make slicing multidimensional arrays less verbose. There are also uses in FastAPI along the lines of «go with the default».
abuckenheimer•1y ago
excellent explanation, to add to this since I was curious about the composition, '%c' is an integer presentation type that tells python to format numbers as their corresponding unicode characters[1] so

'%c' * (length_of_string_to_format) % (number, number, ..., length_of_string_to_format_numbers_later)

is the expression being evaluated here after you collapse all of the 1s + math formatting each number in the tuple as a unicode char for each '%c' escape in the string corresponding to its place in the tuple.

[1] https://docs.python.org/3/library/string.html#format-specifi...

elijahbenizzy•1y ago
Ok do this but for JavaScript
voidUpdate•1y ago
https://en.wikipedia.org/wiki/JSFuck
mariocesar•1y ago
If you're curious, the code in ellipsis results in executing:

    print('hello, world')
mturmon•1y ago
Thank you!

I noticed some ** and * in the thing sent to eval(), which (given that the building blocks are small integers) seemed related to prime factorizations.

The initial %c is duplicated 21 times (3*7, if I read correctly), and then string-interpolated (%c%c%c...) against a long tuple of integers. These integers themselves are composed of products of factors combined using * and **.

There is also one tuple "multiplication" embedded within that long tuple of integers -- (a,b)*2 = (a,b,a,b). That is for the 'l' 'l' in "hello".

It's all very clever and amusingly mathy, with a winking allusion to the construction of natural numbers using sets. It made me Godel.

callamdelaney•1y ago
I think we're really starting to over crowd pythons syntax and I'm not a fan.
noddleah•1y ago
you're telling me you never program in python elliptically??
acbart•1y ago
Pretty sure this would have been possible in Python 2.6. The Ellipsis object has been around for a very long time.
MadVikingGod•1y ago
This behavior can be replicated with any class that has two special methods: __neg__ that returns -1 and __sub__ that accepts ints and returns 1-other.

For example if you make this class:

  class _:
       def __neg__(self):
           return -1
       def __sub__(self, other):
           return 1-other
You get similar behavior:

  >>> --_()
  1
  >>> _()--_()
  2
Fun python for everyone.
maxloh•1y ago
You can do this on JavaScript too.

  alert(1)
  // equals to:
  [][(![]+[])[+!+[]]+(!![]+[])[+[]]][([][(![]+[])[+!+[]]+(!![]+[])[+[]]]+[])[!+[]+!+[]+!+[]]+(!![]+[][(![]+[])[+!+[]]+(!![]+[])[+[]]])[+!+[]+[+[]]]+([][[]]+[])[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+(!![]+[])[+!+[]]+([][[]]+[])[+[]]+([][(![]+[])[+!+[]]+(!![]+[])[+[]]]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+(!![]+[][(![]+[])[+!+[]]+(!![]+[])[+[]]])[+!+[]+[+[]]]+(!![]+[])[+!+[]]]((![]+[])[+!+[]]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[+[]]+([][(![]+[])[+!+[]]+(!![]+[])[+[]]]+[])[+!+[]+[+!+[]]]+[+!+[]]+([]+[]+[][(![]+[])[+!+[]]+(!![]+[])[+[]]])[+!+[]+[!+[]+!+[]]])()
https://jsfuck.com/
nomel•1y ago
Expanding on this a little, I will be replacing all occurrences of 2 with two blobs fighting, with shields:

    >>> 0^((...==...)--++--(...==...))^0
    2
rmah•1y ago
>> There should be one-- and preferably only one --obvious way to do it.

Except for package management, of course. There, we need lots and lots of ways.

blooalien•1y ago
And apparently string formatting which should have an ever growing number of ways to handle it. :shrug: