Seems like the author is doing some redefining here like he's accusing the paper's author.
Perhaps the statement was meant to mean "fulfillment of hereditary characteristics change when society changes" but it wouldn't be that hard to say it if that's what it was supposed to be...
My intuition is that the average genetic human potential, for traits that are ostensibly hierarchical, is higher and narrower than is usually accepted - which is uncomfortable for those whose ambitions require, either directly or by incidence, that most people don't reach that potential. Or, that they're not actually hierarchical traits at all; value depends on context (and is generally made up).
Oddly, the former is probably preferable to most, since, "There is no inherent value in dying old versus young," probably doesn't track for most people.
> Heritability of human lifespan is about 50% when extrinsic mortality is adjusted to be closer to modern levels.
I think by “accounting for confounding factors” they mean setting extrinsic mortality to the equivalent of zero contribution. So you’d expect it to be the asymptote left side.
0: especially enjoyed talking about typos and then writing “doing to go”. I like little jokes like that.
Heritable != Molecular / Genetic Mechanism
There is a conflation of these terms in popular discourse that does a disservice to the field of statistical genetics, imo. There are mechanisms of inheritance that operate various length / time scales other than that of biological macromolecules. For example, if you tell me what language your parents natively speak I can tell you your primary language with >90% accuracy.
So before we start getting 3 replies deep into any thead, please remember that retrospective observational data measured with unqualified instruments is notoriously confounded and that we can barely infer causal structure in controlled functional genomics experiments (much less a GWAS of phewas). So let’s all please keep an open mind and not be so certain about our beliefs.
It seems incredibly disingenuous to lump together epigentics and hair dye when talking about heritability of hair color. We all know when we talk about inheriting hair color we're talking about natural hair color.
> his paper built a mathematical model that tries to simulate how long people would live in a hypothetical world in which no one dies from any non-aging related cause, meaning no car accidents, no drug overdoses, no suicides, no murders, and no (non-age-related) infectious disease.
Which is exactly what everyone means by lifespan in this context. No one on earth is trying to figure out how much genetics contributes to the odds of being hit by a bus.
> veryone seems to be interpreting this paper as follows:
>> Aha! We thought the heritability of lifespan was 23-35%. But it turns out that it’s around 50%. Now we know!
Which is the correct interpretation. Proper elimination of confounding factors is good science. The previous estimates were low because they weren't properly measuring what we are all referring to when we talk about lifespan.
coppsilgold•1h ago
It implies that the only environment that matters is either purely random (truly random accidents, circumstances) or non-systematic (results from non-linear interaction of environment and genes).
When stated that way it almost feels like a tautology because this is what genes exist to do in the first place. To control the interactions of their vessel and environment to the maximum degree. And from the perspective of an individual gene, all the other genes are part of the environment too.
It exists but is uncomputable (need to run Monte Carlo simulations on a human life). All efforts are to approximate it.somenameforme•36m ago
And so in modern times if it turns out that eating less than most people apparently want to contributes to IQ, are you doing something good by eating less, or are they doing something bad by eating more? I think it's basically the same thing, just looked at in different ways.
Earw0rm•10m ago