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Scientists say they've reversed brain aging with a simple nasal spray

https://www.sciencedaily.com/releases/2026/05/260526022018.htm
43•bookmtn•1h ago

Comments

wizardforhire•52m ago
Was looking for the “in mice” in this article and found none… anybody got a link to the paper please
kurthr•47m ago
2.2 Animals and Study Design The study comprised two cohorts of C57BL/6 mice: young adult (3 months old) and late middle-aged (18 months old). We chose 18 months old mice, as this mouse age is approximately equivalent to a 60-year-old human (Dutta and Sengupta 2016).

I posted paper above, DOI was linked at the end.

ddeck•47m ago
Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus

https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...

kurthr•48m ago
The source paper:

https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...

trodney•47m ago
Excellent news if you're a mouse.
instagib•45m ago
“While additional research is still needed before the treatment could be tested in humans, the study offers a striking possibility.”

(In mice)

Topgamer7•27m ago
Pinky and the brain can now sleep soundly as they age like wine
ianburrell•20m ago
We are going to end up with immortal mice.
cookiengineer•14m ago
Always pack your towel for space travel!
CoastalCoder•27m ago
Algernon for Flowers.
delichon•25m ago
I'm afraid of the result if we take someone wrapped in a comforting haze of dementia (I'm getting there) and force them into cold harsh reality. It may be as welcome a sobriety to an alcoholic. If the insurance stops paying does it become Flowers for Algernon?

We have several drugs that emulate dementia in various ways and call them recreational.

MattDamonSpace•22m ago
Presumably this drug (like all the others) is dirt-cheap to synthesize and the only reason anything is expensive is a government granted monopoly that’s nominally encouraging innovation
jmward01•11m ago
I don't grant the assumption that innovation is helped with the current US system. It is entirely possible that it is actually hurt considerably compared to other systems. There is a massive incentive to prolong health problems if you make money on treating them. Even without people being evil, when the major learning signal (money) points constantly towards 'prolong the problem' it isn't hard to imagine that the system that evolves from it is actively worse than nearly any other system with a good loss function like 'health' or even just 'fame and notoriety for the scientists involved'
qnleigh•20m ago
> Behavioral testing showed that treated models performed significantly better on memory and recognition tasks.

"Treated models" - it sounds like they're trying really hard to hide the fact that this was all in mice. From the paper:

> Therefore, using a mouse model, this study investigated whether IN administration of hiPSC-NSC-EVs in late middle age can significantly reduce oxidative stress and curb microglia-mediated neuroinflammaging in the hippocampus.

Cool! But please be honest in your press releases.

ryankrage77•9m ago
ctrl+f'd for 'mice', no results. I can think of no other word than deceit.
Morromist•6m ago
Imagine the political implications of this if it actually worked.

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Scientists say they've reversed brain aging with a simple nasal spray

https://www.sciencedaily.com/releases/2026/05/260526022018.htm
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