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GrapheneOS in 2027 available on high-end Motorola phones

https://grapheneos.social/@GrapheneOS/117078064184215730
289•exceptione•2h ago•163 comments

PostgreSQL for Everything

https://www.raphaelbauer.com:443/posts/postgresql-everything/
63•karlmush•1h ago•37 comments

Geolocating a random island using geometry and CUDA programming

https://yassa9.github.io/osint/gralhix-004/
116•yassa9•2h ago•30 comments

A joke domain purchase turned in geopolitical warfare

https://sprocketfox.io/xssfox/2026/08/19/sondehub-and-war/
122•kareiva•3h ago•12 comments

OpenLogi

https://openlogi.org/en
1134•amatheus•12h ago•322 comments

Proposal to prohibit vibe coded projects from being hosted on Sourcehut

https://lists.sr.ht/~sircmpwn/sr.ht-discuss/%3CDKSTMKM0ZD9N.2FTBDFREZH699@ddevault.org%3E
8•surprisetalk•13m ago•6 comments

Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

https://twitter.com/NoubarAfeyan/status/2090050162441752787
75•heydenberk•1h ago•9 comments

Air Theremin – a browser theremin you play by waving at your webcam

https://theremin.bizibah.com/
119•gurov•4h ago•57 comments

Taffy: A flexible, high-performance, cross-platform UI layout library

https://github.com/DioxusLabs/taffy
15•robin_reala•5d ago•4 comments

Cerebras CS-4

https://www.cerebras.ai/cs4
380•sunils34•14h ago•229 comments

Rings forged from meteorites may have been fashionable among ancient Greek elite

https://phys.org/news/2026-08-forged-meteorites-fashionable-ancient-greek.html
56•pseudolus•5d ago•30 comments

Being ambitious and being a dad

https://nicholascharriere.com/blog/being-ambitious-and-being-a-dad/
713•nichochar•2d ago•533 comments

Supersonic Trebuchet [video]

https://www.youtube.com/watch?v=Co57SfcT-h0
185•CharlesW•4d ago•79 comments

A decades-old bug in Knuth's long division (TAOCP Vol II, Algorithm 4.3.1D)

https://kolja.rs/algorithm-d/
54•nk_kolja•6d ago•12 comments

Palomar: A registry of Lean verified mathematics

https://terrytao.wordpress.com/2026/08/18/palomar-a-registry-of-lean-verified-mathematics/
142•matt_d•11h ago•32 comments

A 3D fruit fly on macOS desktop powered by the real FlyWire connectome

https://github.com/DenisSergeevitch/desktop-fly
338•phoenix120•16h ago•150 comments

λλ: A Programming Language for Silicon Photonics

https://dl.acm.org/doi/10.1145/3789240.3829151
59•matt_d•8h ago•13 comments

How does IKEA come up with names for its products?

https://www.ikea.com/se/en/customer-service/knowledge/articles/6f564c4d-2ccc-46de-b643-545a3948dc...
407•NaOH•20h ago•286 comments

Activation Energy is a good model for a lot of things

https://homosabiens.substack.com/p/activation-energy-is-a-good-model
69•surprisetalk•4d ago•18 comments

The Mojo language (by Modular, now Qualcomm) is now open-source

https://www.modular.com/blog/modcon-announcements
147•flaburgan•6h ago•56 comments

A 25-year-old video patent just expired, ending a legal headache for Linux

https://www.xda-developers.com/25-year-old-brazilian-video-patent-expired-legal-headache-linux/
255•theanonymousone•3d ago•123 comments

Finger: the 1971 social network that never died

https://en.andros.dev/blog/54572bc7/finger-the-1971-social-network-that-never-died/
265•andros•1d ago•87 comments

Claude writing a macOS driver for my obscure HP printer built only for Windows

https://twitter.com/kuberwastaken/status/2089377982536388964
262•porridgeraisin•1d ago•189 comments

Solo – a .so loader for static Linux binaries

https://github.com/pg83/solo
168•zX41ZdbW•14h ago•195 comments

Turbovec – Google's TurboQuant for vector search in Rust

https://github.com/RyanCodrai/turbovec
274•fittingopposite•20h ago•32 comments

The Amazon tax

https://seths.blog/2026/08/the-amazon-tax/
1279•herbertl•1d ago•649 comments

Show HN: Automatically detect and patch walking-dead states in Sierra games

https://github.com/katiahayati/lucasartsifier/
115•wkfauna•12h ago•55 comments

The Vietnam Binh Chau (Chau Tan) Late Tang Wreck

https://www.koh-antique.com/client/tangwreck/tangwreck.html
49•teleforce•12h ago•4 comments

And then the men with guns tell you to do it anyway

https://shkspr.mobi/blog/2026/08/and-then-the-men-with-guns-tell-you-to-do-it-anyway/
380•_djo_•21h ago•289 comments

Scientists stunned by children's lung recovery in ultra low emission zone

https://www.bbc.com/news/articles/c1l1r1zne1ro
353•dabinat•13h ago•299 comments
Open in hackernews

Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

https://twitter.com/NoubarAfeyan/status/2090050162441752787
75•heydenberk•1h ago

Comments

GenerWork•37m ago
This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.
epistasis•36m ago
Ever since I first heard of them a decade ago, it seemed that mRNA therapeutic vaccines were going to be the next wave of massive improvements in care. It's taken a bit longer than I had expected, and it's not that mRNA is the only way to make these sorts of vaccines, it's just so much better than the alternatives.

I'm very very excited to see what comes next.

consumer451•26m ago
This appears to be a potentially huge win for health. The market has Moderna up 125%, which is some sort of validation I suppose.

Related stories:

https://www.fiercebiotech.com/biotech/merck-and-modernas-per...

https://www.reuters.com/legal/litigation/merck-moderna-say-m...

https://www.wsj.com/health/pharma/moderna-merck-vaccine-succ...

MartinMond•26m ago
I listened to a great podcast on this just a month ago - too bad that I thought all of this would obviously be priced in already… https://virological.podigee.io/51-21-cancer-vaccines-how-the...
henry2023•13m ago
Even if you were to optimally price in all available information you still have uncertainty of what will actually happen. i.e. A 1 dollar coin flip has an expected value of 50c before it’s thrown and it will collapse either to zero or to one after the uncertainty is resolved.
reenorap•11m ago
I have 1000 shares of mRNA woohoo! For all the hate I have for the COVID vaccine, I still believe in the underlying technology and I put my money where my mouth was and bought around $20. I think this is just the first of many cancer treatments mRNA will bring and I’m very excited for the future of the technology.
Someone1234•6m ago
> For all the hate I have for the COVID vaccine

Can you clarify that? It saved 100K+ lives even by incredibly conservative estimates, and allowed life to returned to normal at least a year earlier than otherwise.