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CRISPR tech selectively shreds cancer cells, including "undruggable" cancers

https://innovativegenomics.org/news/crispr-technique-selectively-shreds-cancer-cells/
284•gmays•3h ago•64 comments

"Don't You Just Upload It to ChatGPT?"

https://correresmidestino.com/dont-you-just-upload-it-to-chatgpt/
18•speckx•29m ago•5 comments

A PDF that changes based on how its read

https://sgaud.com/texts/pdf
46•SarthakGaud•1h ago•27 comments

Slightly reducing the sloppiness of AI generated front end

https://envs.net/~volpe/blog/posts/reduce-slop.html
104•FergusArgyll•3h ago•63 comments

Looking Forward to Postgres 19: It's About Time

https://www.pgedge.com/blog/looking-forward-to-postgres-19-its-about-time
37•xngbuilds•1h ago•12 comments

Keygen.music

https://keygen.music
84•soupspaces•2h ago•42 comments

A dumpster arrived behind my university's library

https://yalereview.org/article/sheila-liming-the-end-of-books
99•mooreds•4h ago•71 comments

Where Did Earth Get Its Oceans? Maybe It Made Them Itself

https://www.quantamagazine.org/where-did-earth-get-its-oceans-maybe-it-made-them-itself-20260612/
58•ibobev•2h ago•37 comments

I Am Not a Reverse Centaur

https://blog.miguelgrinberg.com/post/i-am-not-a-reverse-centaur
7•ibobev•28m ago•0 comments

Malware developers added nuclear and biological weapons text to to their spyware

https://twitter.com/jsrailton/status/2064661778978533571
81•marc__1•21h ago•66 comments

Pirates, a naval warfare game inspired by Sid Meier's Pirates

https://piwodlaiwo.github.io/pirates/
16•iweczek•1h ago•3 comments

Launch HN: BitBoard (YC P25) – Analytics Workspace for Agents

https://bitboard.work/
11•arcb•1h ago•4 comments

How to Setup a Local Coding Agent on macOS

https://ikyle.me/blog/2026/how-to-setup-a-local-coding-agent-on-macos
10•kkm•46m ago•1 comments

A Call to Action: Stop the FCC's KYC Regime

https://blog.lopp.net/call-to-action-stop-the-fcc-kyc-regime/
256•FergusArgyll•3h ago•159 comments

Maxproof

https://arxiv.org/abs/2606.13473
107•ilreb•6h ago•8 comments

Hazel (YC W24) Is Hiring a Full Stack Engineer

https://www.ycombinator.com/companies/hazel-2/jobs/3epPWgu-full-stack-engineer-ts-sci
1•augustschen•5h ago

Introduction to UEFI HTTP(s) Boot with QEMU/OVMF

https://blog.yadutaf.fr/2026/06/12/introduction-to-uefi-https-boot-qemu-ovmf/
29•jtlebigot•3h ago•5 comments

AI agent bankrupted their operator while trying to scan DN42

https://lantian.pub/en/article/fun/ai-agent-bankrupted-their-operator-scan-dn42lantian.lantian/
1289•xiaoyu2006•13h ago•468 comments

There Is Life Before Main in Rust

https://grack.com/blog/2026/06/11/life-before-main/
19•mmastrac•1d ago•4 comments

WASI 0.3

https://bytecodealliance.org/articles/WASI-0.3
187•mavdol04•4h ago•73 comments

Tesla Full Self Driving uses bicycle lane in official Denmark approval video

https://politiken.dk/danmark/forbrug/biler/art10875514/Allerede-12-sekunder-inde-i-PR-videoen-beg...
19•Veserv•32m ago•3 comments

Law Enforcement's "Warrior" Problem

https://harvardlawreview.org/forum/vol-128/law-enforcements-warrior-problem/
14•bookofjoe•1h ago•5 comments

Show HN: StackScope – I crawled over 40k indie launches to see what they ship

https://stackscope.dev/
19•datafreak_•2h ago•3 comments

New privacy frontier: Europe eyes crackdown on smart glasses

https://www.politico.com/www.politico.eu/article/new-privacy-frontier-europe-eyes-crackdown-smart...
37•1vuio0pswjnm7•1h ago•20 comments

If you are asking for human attention, demonstrate human effort

https://tombedor.dev/human-attention-and-human-effort/
1358•jjfoooo4•19h ago•433 comments

AUR packages compromised with Infostealer and Rootkit

https://discourse.ifin.network/t/400-aur-packages-compromised-with-infostealer-and-rootkit/577
234•keyle•12h ago•158 comments

Encrypted Spaces An architecture for collaborative applications

https://encryptedspaces.org/
40•_____k•5h ago•5 comments

Show HN: Script to bulk delete Claude chats from the web UI

https://github.com/MatteoLeonesi/bulk-delete-claude-chat
36•ML0037•3h ago•13 comments

How we made hit video game Prince of Persia

https://www.theguardian.com/culture/2026/jan/05/raiders-of-the-lost-ark-hit-video-game-prince-of-...
238•msephton•2d ago•92 comments

Kimi K2.7-Code: open-source coding model with better token efficiency

https://huggingface.co/moonshotai/Kimi-K2.7-Code
329•nekofneko•7h ago•171 comments
Open in hackernews

Linear Programming for Fun and Profit

https://modal.com/blog/resource-solver
62•hmac1282•1y ago

Comments

ayhanfuat•1y ago
> X = [x1, ..., Xn]: instances of each type to launch

Is this a continuous variable? Seems discrete to me. I am surprised it is solved by simplex.

Frummy•1y ago
It's the answer, a vector of integers
ayhanfuat•1y ago
Simplex cannot give a vector of integers though, unless the constraint matrix is unimodular. Maybe the integrality constraint was relaxed.
cweld510•1y ago
You're right -- we do relax the integrality constraint, gaining performance at the expense of some precision, and we're generally able to paper over the difference at scheduling time. We've investigated integer linear programming for some use cases, but for solves to run quickly, we have to constrain the inputs significantly.
ayhanfuat•1y ago
Thanks for the clarification. I guess it wouldn’t matter much if the numbers are large. Initially I thought they were mostly ones and zeros.
stncls•1y ago
If this is business critical for you, you may want to switch to a faster solver. Glop is very nice, but it would be reasonable to expect a commercial solver (Gurobi, XPress, COpt) to be 60x faster [1]. By the same measure, the best open source solvers (CLP, HiGHS) are 2-3x faster than Glop.

Actually, the commercial solvers are so fast that I would not be surprised if they solved the IP problem as fast as Glop solves the LP. (Yes, the theory says it is impossible, but in practice it happens.) The cost of a commercial solver is 10k to 50k per license.

[1] ... this 60x number has very high variance depending on the type of problem, but it is not taken out of nowhere, it comes from the Mittelmann LP benchmarks https://plato.asu.edu/ftp/lpopt.html There are also benchmarks for other types of problems, including IP, see the whole list here: https://plato.asu.edu/bench.html

petters•1y ago
If you are able to paper over the fractional numbers and get a usable solution, an integer solver should also be able to find a feasible solution easily. Perhaps not optimal, but better than just solving the LP and rounding
hustwindmaple1•1y ago
You are basically doing a heurstic. Your solutions are not guaranteed to be optimal. Integer programming is the way to do.
cweld510•1y ago
Great to see this post here -- really enjoyed writing it! I think it's really cool how an algorithm from an operational research context can play a critical role in a high-availability large-scale cloud service.
sumtechguy•1y ago
LP is a shockingly good way to optimize a system. If you can put inputs/outputs into the correct form. Had an econ prof that loved these things for doing supply/demand maxima and minimum finding. He didnt outright say it but I think it was his current line of study when I was taking classes from him the 90s. I thought that, as he managed to bring it up in every class he taught.
Onavo•1y ago
Well, kantorovich did win the Nobel for inventing that.
underanalyzer•1y ago
Neat article. I do wish it mentioned that there are polynomial time algorithms to solve linear programming problems. According to the Google ortools docs it has the option to use those as well (but not with the GLOP solver). Might be good for when simplex is struggling (https://developers.google.com/optimization/lp/lp_advanced)
stncls•1y ago
You're right, but it's very subtle and complicated.

In theory, the simplex method is not known to be polynomial-time, and it is likely that indeed it is not. Some variants of the simplex method have been proven to take exponential time in some worst cases (Klee-Minty cubes). What solvers implement could be said to be one such variant ("steepest-edge pricing"), but because solvers have tons of heuristics and engineering, and also because they work in floating-point arithmetic... it's difficult to tell for sure.

In practice, the main alternative is interior-point (aka. barrier) methods which, contrary to the simplex method, are polynomial-time in theory. They are usually (but not always) faster, and their advantage tends to increase for larger instances. The problem is that they are converging numerical algorithms, and with floating-point arithmetic they never quite 100% converge. By contrast, the simplex method is a combinatorial algorithm, and the numerical errors it faces should not accumulate. As a result, good solvers perform "crossover" after interior-point methods, to get a numerically clean optimal solution. Crossover is a combinatorial algorithm, like the simplex method. Unlike the simplex method though, crossover is polynomial-time in theory (strongly so, even). However, here, theory and practice diverge a bit, and crossover implementations are essentially simplified simplex methods. As a result, in my opinion, calling iterior-point + crossover polynomial-time would be a stretch.

Still, for large problems, we can expect iterior-point + crossover to be faster than the simplex method, by a factor 2x to 10x.

There is also first-order methods, which are getting much attention lately. However, in my experience, you should only use that if you are willing to tolerate huge constraint violations in the solution, and wildly suboptimal solutions. Their main use case is when other solvers need too much RAM to solve your instance.

Onavo•1y ago
The most interesting question is how you scrape the prices. The cloudprovider really need to provide an API.
underanalyzer•1y ago
Very interesting! Thanks for the reply. I wonder if they tried these other solvers and decided they were either too slow b/c their problems were too small or the answers were too inaccurate