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Third patient dies from acute liver failure caused by a Sarepta gene therapy

https://www.biocentury.com/article/656520/third-death-from-a-sarepta-gene-therapy
112•randycupertino•2h ago•25 comments

Asynchrony Is Not Concurrency

https://kristoff.it/blog/asynchrony-is-not-concurrency/
46•kristoff_it•1h ago•26 comments

lsr: ls with io_uring

https://rockorager.dev/log/lsr-ls-but-with-io-uring/
261•mpweiher•7h ago•145 comments

Show HN: I built library management app for those who outgrew spreadsheets

https://www.librari.io/
17•hmkoyan•1h ago•4 comments

AI CapEx Is Eating the Economy

https://paulkedrosky.com/honey-ai-capex-ate-the-economy/
42•throw0101c•41m ago•16 comments

Replication of Quantum Factorisation Records with a VIC-20, an Abacus, and a Dog

https://eprint.iacr.org/2025/1237
30•teddyh•1h ago•6 comments

Trying Guix: A Nixer's impressions

https://tazj.in/blog/trying-guix
106•todsacerdoti•3d ago•24 comments

CP/M creator Gary Kildall's memoirs released as free download

https://spectrum.ieee.org/cpm-creator-gary-kildalls-memoirs-released-as-free-download
207•rbanffy•10h ago•102 comments

Cancer DNA is detectable in blood years before diagnosis

https://www.sciencenews.org/article/cancer-tumor-dna-blood-test-screening
74•bookofjoe•2h ago•33 comments

Mango Health (YC W24) Is Hiring

https://www.ycombinator.com/companies/mango-health/jobs/3bjIHus-founding-engineer
1•zachgitt•2h ago

Benben: An audio player for the terminal, written in Common Lisp

https://chiselapp.com/user/MistressRemilia/repository/benben/home
24•trocado•3d ago•1 comments

The Year of Peak Might and Magic

https://www.filfre.net/2025/07/the-year-of-peak-might-and-magic/
20•cybersoyuz•3h ago•3 comments

How I keep up with AI progress (and why you must too)

https://blog.nilenso.com/blog/2025/06/23/how-i-keep-up-with-ai-progress/
98•itzlambda•2h ago•59 comments

Trying to send a sticker in Steam Chat burned through a month of mobile data

https://old.reddit.com/r/Steam/comments/1m000kp/trying_to_send_a_sticker_in_steam_chat_burned/
5•danso•55m ago•0 comments

Section 174 is reversed! Mostly, that is.

https://newsletter.pragmaticengineer.com/p/the-pulse-section-174-is-reversed
83•jawns•2h ago•40 comments

I'm Peter Roberts, immigration attorney who does work for YC and startups. AMA

132•proberts•5h ago•214 comments

Hundred Rabbits – Low-tech living while sailing the world

https://100r.co/site/home.html
188•0xCaponte•4d ago•50 comments

A New Geometry for Einstein's Theory of Relativity

https://www.quantamagazine.org/a-new-geometry-for-einsteins-theory-of-relativity-20250716/
28•jandrewrogers•5h ago•0 comments

LibreOffice slams Microsoft for locking in Office users w/ complex file formats

https://www.neowin.net/news/libreoffice-calls-out-microsoft-for-using-complex-file-formats-to-lock-in-office-users/
112•bundie•4h ago•75 comments

How to Get Foreign Keys Horribly Wrong

https://hakibenita.com/django-foreign-keys
32•Bogdanp•3d ago•9 comments

When root meets immutable: OpenBSD chflags vs. log tampering

https://rsadowski.de/posts/2025/openbsd-immutable-system-logs/
124•todsacerdoti•12h ago•41 comments

Making a StringBuffer in C, and questioning my sanity

https://briandouglas.ie/string-buffer-c/
3•coneonthefloor•3d ago•0 comments

HathiTrust Digital Library

https://www.hathitrust.org/
52•djoldman•3d ago•16 comments

CoCo1 composite video

https://www.leadedsolder.com/2025/07/15/tandy-trs80-coco-composite-mod-aquarius.html
22•zdw•3d ago•1 comments

Dear valued user, You have reached the error page for the error page

https://imgur.com/a/2H7HVcU
153•Alex3917•5h ago•34 comments

Psilocybin decreases depression and anxiety in cancer patients (2016)

https://pmc.ncbi.nlm.nih.gov/articles/PMC5367557/
234•Bluestein•9h ago•227 comments

Exposed MCP servers across the internet

https://www.knostic.ai/blog/mapping-mcp-servers-study
69•gepeto42•7h ago•26 comments

Row Polymorphic Programming

https://www.stranger.systems/posts/by-slug/row-polymorphic-programming.html
44•todsacerdoti•4d ago•24 comments

Ask HN: Any active COBOL devs here? What are you working on?

216•_false•7h ago•161 comments

Firefox-patch-bin, librewolf-fix-bin AUR packages contain malware

https://lists.archlinux.org/archives/list/aur-general@lists.archlinux.org/thread/7EZTJXLIAQLARQNTMEW2HBWZYE626IFJ/
91•rrampage•2h ago•81 comments
Open in hackernews

Trying Guix: A Nixer's impressions

https://tazj.in/blog/trying-guix
105•todsacerdoti•3d ago

Comments

idlip•3d ago
Its nice read. We need more of comparative posts by user familiar with both nix and guix.

We see bias with most discussions.

Only cons with Guix I see is, lack of infrastructure and less volunteers to work on guix eco-system. If its solved, I can imagine guix can improve exponentially.

kwk1•3h ago
Guix recently moved from Savannah to Codeberg, which hopefully will help move the needle on infrastructure and volunteer quantity concerns.
tempfile•3h ago
The major con is in the article, it is super slow to update. Half an hour is just crazy, nobody will move to that if they know.
kyoji•3h ago
I play around with a Guix install in a VM, and with less than half of my system resources, a `guix pull` with a `guix system reconfigure ...` takes about 10 minutes. That said, if a pull happens to include a kernel update it can take much longer. I think pinning large packages (like the kernel) that may not need incidental updating is key to keeping pull times lower.
tadfisher•2h ago
10 minutes is still an order of magnitude slower than a nixos-rebuild if you're hitting the cache, and there's no issue with forgetting to rebuild the guix profile. If you include nonguix (as is required for the 99% of users who need nonfree blobs) you get the 30-50 minutes as described in the article. I believe Nix-the-language being lazily evaluated is a big part of this; you can even inadvertently evaluate nixpkgs multiple times and not notice.
opan•1h ago
>(as is required for the 99% of users who need nonfree blobs)

If you forgo the built-in WiFi, the ThinkPad T440p (Haswell) works fine without any blobs (speaking from experience). I think all newer gens need iGPU blobs, sadly, but I wanted to point out a viable middle ground between modern Nvidia gamerware setups and Librebooted X200s that can barely browse the web.

kwk1•2h ago
It doesn't usually take that long, but the first `guix pull` is quite slow, and what should be a no-op of running it a second time immediately afterwards also takes too long.

Edit: Just to provide a measurement, on my Framework 13 with AMD Ryzen 5 7640U, a `guix pull` which pulled in 1 nonguix commit and 64 guix commits took 2m10s, and a subsequent no-op `guix pull` took 1m18s.

nbf_1995•2h ago
From the article:

> My goal was to take my Unchartevice laptop with its strange Zhaoxin x86_64-compatible CPU...

> Sure, this is a laptop with a CPU broadly equivalent to old Intel Atom CPUs...

Yes, guix pull is slow, but the author is using some old/exotic hardware. The last time I tried guix on a 5th gen dual core i5, the initial pull was not that slow. And as other commenters have pointed out. The first pull is the slowest by far.

positron26•2h ago
Important question is if its fixable.

Nix is pathologically recursive, lazy, and uses fixed points, things that are very apt to changing something that cascades through a bunch of dependents. Nix's runtime is not magic. Guile should be able to expose a language and evaluate it in a similar way.

For my part, I've not opted into Guix because it's a GNU project, and I've decided to avoid anything in the FSF sphere of influence. Their orthodoxy turns off contributors and they have a history of taking insular hard-liner approaches that are utopian. Outside of coreutils that are about to be fully subsumed by rewrite-it-in-Rust (which has a community that is not a fan of the GPL), what has had FSF backing and been successful? Linus starts two of the most influential pieces of software in human civilization and RMS wants to name the awards. The pragmatic culture that shifted away from the FSF has I think largely adopted Nix, and it shows. Nix is open for business, available on lots of platforms, has commercial entities built around its success.

kwk1•2h ago
Agreed on the assessment, but for me, part of the appeal of Guix is a way to turn that ship around.
pmarreck•1h ago
isn't there nonguix? you know, the Ashley Madison of guix?
bheadmaster•1h ago
> what has had FSF backing and been successful?

GCC is still indispensable. I doubt it will be rewritten in Rust any time soon.

positron26•35m ago
GCC was one subject of The Cathedral and the Bazaar. The development process was changed to more closely mimic Linux and the original GCC steering committee was dissolved. Cygnus had a big role in GCC becoming an industry fixture for its hayday. Eventually the lack of big revenue meant that the license became an annoyance that industry could deal with by nurturing Clang and LLVM with acceptable quantities of money. In FSF orthodoxy, they were supposed to lose that fight.
davexunit•1h ago
For what it's worth the association with GNU is basically historical at this point. RMS has never accepted the original vision of the project (to be the official GNU OS) and the project outgrew GNU's dilapidated infrastructure a long time ago, which the project is finally addressing with the migration to Codeberg. The FSF gave the project a place for people to donate specifically to Guix but have never really embraced it, otherwise. That has been superseded by a dedicated European nonprofit for Guix. The most recent Guix Days gathering before FOSDEM featured a lengthy conversation of breaking ties with GNU entirely but no decision has been made on that, yet.
davexunit•1h ago
Regular updates do not take anywhere near a half hour.
msgilligan•1h ago
> We need more of comparative posts

The article focuses on a comparison between GUIX _system_ and NixOS. It would be interesting to see an equally thoughtful comparison that just focuses on GUIX vs. NIX as package managers used on another Linux distribution (e.g. Debian.)

In this case, GUIX might fare better as you won't have to worry about the complexities introduced by binary blobs needed for boot, etc.

CBLT•1h ago
I had a similar experience. After running `guix pull` a couple of times on an ancient laptop I shelved the project until I made a distcc cluster (I never did).
pkulak•1h ago
> why flakes are nonsense

Oh wow, I want to hear more about that. I love flakes, but I've known they are controversial, and never really heard why.

realo•1h ago
I like flakes... I use flakes.

You love flakes... keep using them!

The rest is politics.

peterldowns•1h ago
Very interesting writeup, as a long-time Nix user I've always been interested in trying guix but never gotten around to it. Great post overall.

> The thing is, I'm not actually sure if Guix's better documentation helps smooth the onboarding in any way because you have to already know Scheme, which is a more complex language than Nix.

LMAO absolutely not. Nix-the-language is the worst programming language I've ever had the misfortune to interact with. I picked up Scheme in about 1 day during a class in college. It's night-and-day different.

otabdeveloper4•1h ago
> Nix-the-language is the worst programming language I've ever had the misfortune to interact with

Nix-the-language is just a subset of Javascript with built-in laziness and a slightly different syntax. An absolute bog-standard and mainstream way of thinking about programs in 2025.

That said, Nix-the-language also suffers from all the same birth defects that manifest themselves in frontend development.

grep_name•58m ago
> That said, Nix-the-language also suffers from all the same birth defects that manifest themselves in frontend development

That must be it. The GP's comment really resonated with me, in that learning scheme felt like no task at all whereas I STILL feel uncomfortable with the nix programming language and ecosystem despite using nixOS exclusively on my personal laptop for two years and on my work machine for about half a year now. I've always fumbled over frontend / javascript development though, and avoid it as much as I can at work although I still end up working in it every year or so.

Nix only won out for me because of the mac compatibility, without which I can't really use it at work

positron26•59m ago
> Nix-the-language is the worst programming language I've ever had the misfortune to interact with.

I feel the same.

The multi-line strings and string interpolation are both really nice. Unfortunately a lot of the text being munged is bash and usually already ugly, so the result is double-ugly.

The functional aspects are okay. However, as an expression language and being primarily used in a declarative way, it is frequent to have almost no idea what's going on in Nix. Reading the code and understanding the evaluation are extremely far apart.

callPackage... It's something I thought would be cool in a language until I actually experienced the depth of disorientation it can cause.

The remaining syntax has a lot of "but why?" where it just seems to do its own thing relative to other languages, which makes it harder to get into a rhythm.

Some of the subject matter is the real culprit. The cross compiling sliding window thing... I've studied it several times. If I had to actually do something with it, straight to the LLM. Compilers have targets.

jdudjxxjz•38m ago
Cgmm

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