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Semaglutide linked to lower predicted dementia risk

https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/dad2.70432
337•randycupertino•8h ago•234 comments

Cultivating a state of mind where new ideas are born (2023)

https://www.henrikkarlsson.xyz/p/good-ideas
68•felixbraun•4h ago•17 comments

AI in drug discovery – what it is, where we stand and the path forward

https://www.science.org/content/blog-post/so-how-ai-drug-discovery-doing-really
80•AnodicElegy•5h ago•42 comments

Abdominal fat predicts heart disease risk better than BMI

https://www.acc.org/about-acc/press-releases/2026/08/11/14/59/abdominal-fat-predicts-heart-diseas...
131•theanonymousone•3h ago•95 comments

At-home test for infected ticks could improve Lyme Disease diagnosis

https://www.smithsonianmag.com/innovation/the-first-at-home-test-for-infected-ticks-could-improve...
207•gmays•10h ago•71 comments

RISC-V: They Should Have Known Better

https://dmitry.gr/?r=06.%20Thoughts&proj=12.%20RV
221•dmitrygr•1d ago•291 comments

AI has access to a vastly larger working memory than the human brain

https://davidepiffer.com/p/ai-isnt-outthinking-mathematicians
398•rzk•6h ago•353 comments

Tracking down a Zsh history data loss bug

https://michael.stapelberg.ch/posts/2026-08-09-zsh-history-truncation-bug/
27•ingve•3h ago•3 comments

Auto-research with codex: How I achieved a 232x Faster Kernel

https://sankalp.bearblog.dev/autoresearch/
391•tosh•13h ago•86 comments

Super El Niño Keeps Growing as New Forecasts Reach Record Territory Ahead Winter

https://www.severe-weather.eu/long-range-2/super-el-nino-growth-accelerating-to-record-strength-f...
54•dgellow•5h ago•15 comments

ChatGPT lost 22 points of web share in a year

https://aicharts.grok.me/c/market-share
3•echohive42•31m ago•1 comments

A fortuitous decade as an indie software developer

https://lapcatsoftware.com/articles/2026/8/3.html
17•frizlab•5d ago•1 comments

Bede Liu, a digital signal processing pioneer, has died

https://spectrum.ieee.org/digital-signal-processing
52•Jimmc414•3h ago•2 comments

A spectre is haunting Unicode

https://www.dampfkraft.com/ghost-characters.html
162•sensanaty•10h ago•48 comments

Tea5767-Radio-Tuner

https://github.com/turtushig22-blip/tea5767-radio-tuner
4•turtushig22•59m ago•0 comments

Tess's Android Wayland Compositor

https://github.com/wmww/tawc
39•schmorptron•6h ago•3 comments

Credit card debt rises to $1.26T, nearing all-time record

https://abc7.com/story/credit-card-debt-rises-126-trillion-nearing-time-record/19667289/
26•lxm•1h ago•22 comments

Working with AI feels more like leadership than coding

https://allen.bargi.org/notes/working-with-ai-feels-like-leadership/
261•allenb•14h ago•168 comments

Voltair (YC W26) Is Hiring a Test Flight Engineer

https://www.ycombinator.com/companies/voltair/jobs/sSOD2Ox-flight-test-engineer
1•wweissbluth•6h ago

SugarTrack – an offline Android logbook for blood sugar (no account, no cloud)

https://sugartrack-beta.vercel.app/
15•hunzaboy•2h ago•3 comments

The Wow signal was a strong narrowband radio signal detected on August 15, 1977

https://en.wikipedia.org/wiki/Wow!_signal
56•firefax•3h ago•11 comments

Humazon

https://hughhowey.com/humazon/
20•herbertl•4h ago•9 comments

Jaithon 3, a fast programming language with the perfect syntax

https://github.com/abhiramasonny/jaithon
17•AbhiramaVS•4d ago•11 comments

I Remain a Skeptic

https://blog.jsbarretto.com/post/i-remain-a-skeptic
48•lproven•8h ago•22 comments

Show HN: Eigendrum - Draw any shape and hear what it sounds like as a drum

https://baselashraf81.github.io/eigendrum/
198•BaselAshraf81•5d ago•93 comments

Modeling and Verification of Keeta's Consensus [pdf]

https://xescu.re/keeta-consensus.pdf
10•xescure•3h ago•1 comments

Pizza Box Project Stack

https://cblgh.org/posts/2026-07-31-pizza-box-project-stack/
31•surprisetalk•4d ago•3 comments

2D Gaussian Splatting for Bézier Spline Line Art Vectorization

https://studios.disneyresearch.com/2026/07/16/2d-gaussian-splatting-for-bezier-spline-line-art-ve...
61•Jimmc414•1d ago•4 comments

The mathematical beauty of hyperbezier curves

https://linebender.org/blog/hyperbezier/
187•raphlinus•6d ago•36 comments

An image can overflow

https://master.dev/blog/something-nobody-told-you-about-the-image-element-it-can-overflow/
14•ibobev•4d ago•5 comments
Open in hackernews

Self-Hosting Moose with Docker Compose, Redis, Temporal, Redpanda and ClickHouse

https://docs.fiveonefour.com/moose/deploying/self-hosting/deploying-with-docker-compose
50•Callicles•1y ago

Comments

Callicles•1y ago
I put this Docker-Compose recipe together to make kicking the tires on Moose—our open-source data-backend framework—almost friction-less.

What you get:

• A single docker compose up that spins up ClickHouse, Redpanda, Redis and Temporal with health-checks & log-rotation already wired.

• Runs comfortably on an 8 GB / 4-core VPS; scale-out pointers are in the doc if you outgrow single-node.

• No root Docker needed; the stack follows the hardening tips ClickHouse & Temporal recommend.

Why bother?

Moose lets you model data pipelines in TypeScript/Python and auto-provisions the OLAP tables, streams and APIs—cuts a lot of boilerplate. Happy to trade notes on the approach or hear where the defaults feel off.

Docs: https://docs.fiveonefour.com/moose/deploying/self-hosting/de...

18-min walkthrough video: https://www.youtube.com/watch?v=bAKYSrLt8vo

pitah1•1y ago
I have a small open-source project, that uses docker compose behind the scenes, to help startup any service. You can look to add it in (or I am also happy to add it in) and then users are one command away from running it (insta moose). Recently just added in lakekeeper and various data annotation tools.

insta-infra: https://github.com/data-catering/insta-infra

Callicles•1y ago
Interesting. How do you do dependencies between those pieces of infrastructure if there's any? For example, in our Docker Compose file, we have temporal that depends on progress and then moose depends on temporal. How is that expressed in Insta-Infra?
pitah1•1y ago
It leverages docker compose 'depends_on' for the dependencies (https://docs.docker.com/compose/how-tos/startup-order/). For example, airflow depends on airflow-init container to be completed successfully which then depends on postgres.

https://github.com/data-catering/insta-infra/blob/main/cmd/i...

mitchellsuzuki•1y ago
this is too perfect. as an SRE who often needs to hand roll my own deployments in k8s or w/e medium, these are the docs that really accelerate my path to production.
Havoc•1y ago
For everyone else confused too…think moose in this context is probably this:

https://mooseframework.inl.gov/

oatsandsugar•1y ago
Actually, this https://github.com/514-labs/moose
LargoLasskhyfv•1y ago
I thought of https://moosetechnology.org/ and wondered why I'd need all that fancy other stuff?
Twirrim•1y ago
Maybe this is the greybeard in me, but I first thought about https://metacpan.org/pod/Moose, and catalyst (http://catalyst.perl.org/)
GuestFAUniverse•1y ago
hehehehe At least I'm not alone...
ajtaylor•
nivertech•1y ago
How Moose compares to more traditional ELT data pipeline orchestration frameworks, like Airflow, Dagster, dbt, DuckDB for transformation steps.

I think one of the reasons to use an orchestration framework is integations.

Callicles•1y ago
Hi!

We are built on top of them. Right now the techs above are what’s backing the implementation but we want to add different compatibilities. So that you can eventually have for example airflow backing up your orchestration instead of temporal.

You can think of moose as the pre-built glue between those components with the equivalent UX of a web framework (ie you get hit reloading, instant feedback, etc…)

huksley•1y ago
You don't publish a ready-made image anywhere? That would be easier to spin it up without installing locally moose first. Kind of defeats the purpose of Docker Compose recipe.

And those ports bindings, is it really necessary to expose it on 0.0.0.0 by default.

Callicles•1y ago
Not sure if this is what you are asking about, so if I misread feel free to correct me. You don’t have to install moose first on the deployment machine, in the tutorial I go through that to generate a dummy moose application to be deployed.

It is the same idea as a nextjs application you deploy through docker, you have your application and then you build your docker container that contains your code, then you can deploy that.

I tried to limit the port bindings, we usually expose moose itself since one of the use case is collecting data for product analytics from a web front end, which pushes data to moose. And then usually people want to expose rest apis on top of the data they have collected. The clickhouse ports could be fully closed, this was an example of if you want to connect PowerBook to it

1y ago
Clearly I'm showing my age here too