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A Visual Guide to DNA Sequencing

https://www.asimov.press/p/dna-sequencing

25•surprisetalk•3h ago

Comments

voidUpdate•1h ago

So it's not just a strong magnifying glass and tiny tweezers?

adrian_b•16m ago

The nanopore technique described towards the end is not that far from your description.

ben1040•1h ago

I worked in this space for over a decade. It's so weird to me to see the workhorse sequencing hardware like the ABI 37x/37xx series, 454, and Illumina machines now as literal museum pieces.

MacBook Neo

https://www.apple.com/newsroom/2026/03/say-hello-to-macbook-neo/

614•dm•3h ago•940 comments

Something is afoot in the land of Qwen

https://simonwillison.net/2026/Mar/4/qwen/

142•simonw•1h ago•49 comments

Nobody Gets Promoted for Simplicity

https://terriblesoftware.org/2026/03/03/nobody-gets-promoted-for-simplicity/

552•aamederen•5h ago•318 comments

“It turns out” (2010)

https://jsomers.net/blog/it-turns-out

138•Munksgaard•2h ago•57 comments

Glaze by Raycast

https://www.glazeapp.com/

130•romac•4h ago•74 comments

Welcome to the Wasteland: A Thousand Gas Towns

https://steve-yegge.medium.com/welcome-to-the-wasteland-a-thousand-gas-towns-a5eb9bc8dc1f

24•nop_slide•50m ago•20 comments

Motorola GrapheneOS devices will be bootloader unlockable/relockable

https://grapheneos.social/@GrapheneOS/116160393783585567

1091•pabs3•16h ago•437 comments

Qwen3.5 Fine-Tuning Guide – Unsloth Documentation

https://unsloth.ai/docs/models/qwen3.5/fine-tune

131•bilsbie•5h ago•37 comments

Libre Solar – Open Hardware for Renewable Energy

https://libre.solar

95•evolve2k•3d ago•23 comments

Government grant-funded research should not be published in for-profit journals

https://www.experimental-history.com/p/the-one-science-reform-we-can-all

181•sito42•2h ago•96 comments

Agentic Engineering Patterns

https://simonwillison.net/guides/agentic-engineering-patterns/

365•r4um•12h ago•207 comments

MyFirst Kids Watch Hacked. Access to Camera and Microphone

https://www.kth.se/en/om/nyheter/centrala-nyheter/kth-studenten-hackade-klocka-for-barn-1.1461249

36•jidoka•4h ago•7 comments

RFC 9849. TLS Encrypted Client Hello

https://www.rfc-editor.org/rfc/rfc9849.html

211•P_qRs•10h ago•101 comments

Emails to Outlook.com rejected due to a fault or overzealous blocking rules

https://www.theregister.com/2026/03/04/users_fume_at_outlookcom_email/

68•Bender•6h ago•43 comments

RE#: how we built the fastest regex engine in F#

https://iev.ee/blog/resharp-how-we-built-the-fastest-regex-in-fsharp/

146•exceptione•3d ago•53 comments

Medical journal says the case reports it has published for 25 years are fiction

https://retractionwatch.com/2026/03/03/canadian-pediatric-society-journal-correction-case-reports...

90•Tomte•2h ago•31 comments

Jiga (YC W21) Is Hiring

https://jiga.io/about-us

1•grmmph•5h ago

TikTok will not introduce end-to-end encryption, saying it makes users less safe

https://www.bbc.com/news/articles/cly2m5e5ke4o

315•1659447091•16h ago•313 comments

Greg Knauss Is Losing Himself

https://shapeof.com/archives/2026/2/greg_knauss_is_losing_himself.html

48•wallflower•2d ago•31 comments

A Visual Guide to DNA Sequencing

https://www.asimov.press/p/dna-sequencing

25•surprisetalk•3h ago•3 comments

A CPU that runs entirely on GPU

https://github.com/robertcprice/nCPU

195•cypres•13h ago•97 comments

Sea level much higher than assumed in most coastal hazard assessments

https://www.nature.com/articles/s41586-026-10196-1

26•jacquesm•1h ago•1 comments

SRGB↔XYZ Conversion (2021)

https://mina86.com/2019/srgb-xyz-conversion/

5•kqr•2d ago•3 comments

Elevator Saga: The elevator programming game (2015)

https://play.elevatorsaga.com/index.html

69•xmprt•3d ago•13 comments

Show HN: Stacked Game of Life

https://stacked-game-of-life.koenvangilst.nl/

129•vnglst•4d ago•24 comments

Toxic combinations: when small signals add up to a security incident

https://blog.cloudflare.com/toxic-combinations-security/

13•unknownhad•5d ago•2 comments

Better JIT for Postgres

https://github.com/vladich/pg_jitter

122•vladich•11h ago•55 comments

Modern Illustration: Archive of illustration from c.1950-1975

https://www.modernillustration.org

44•eustoria•4d ago•4 comments

Claude's Cycles [pdf]

https://www-cs-faculty.stanford.edu/~knuth/papers/claude-cycles.pdf

733•fs123•1d ago•309 comments

Chimpanzees Are into Crystals

https://www.nytimes.com/2026/03/04/science/chimpanzees-crystals.html

65•jimnotgym•9h ago•40 comments