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The Psychedelic Toad of the Sonoran Desert

https://en.wikipedia.org/wiki/Bufo_Alvarius:_the_Psychedelic_Toad_of_the_Sonoran_Desert
18•simonebrunozzi•6d ago

Comments

julienchastang•56m ago
Completely fascinating video on this topic just recently:

https://www.wsj.com/video/the-race-to-commercialize-the-worl...

mettamage•54m ago
Have any studies been done on this particular psychedelic? I'm curious.
throawayonthe•50m ago
https://en.wikipedia.org/wiki/5-MeO-DMT has some references and the "further reading" links might have way more
ulrikrasmussen•33m ago
Most recent I know of: https://www.psychiatrictimes.com/view/blp-003-for-treatment-...

Mebufotenin is 5-MeO-DMT

john_strinlai•23m ago
plenty of scientific and not-really-scientific links available at erowid for 5-meo-dmt

https://www.erowid.org/chemicals/5meo_dmt/5meo_dmt.shtml

scientific references specifically at https://www.erowid.org/references/refs.php?S=5meo_dmt

Aurornis•9m ago
A couple groups are trying to commercialize it. There have been some trials, but they're all relatively limited by depression trial standards. Double-blind is impossible because the participants know 100% if they've received it or not. Someone volunteering to sign up for a depression study to receive psychedelic drugs is probably a believer that they work, so the placebo groups end up disappointed and the active groups are happy they got assigned the psychedelic they signed up.

One of the latest studies: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/...

They followed participants for 8 days, which is pretty disappointing. They really need to follow people for several months to see if anything holds or if it's a short-term placebo effect that wears off.

solomonb•44m ago
Can we please leave the fucking toads alone?

This is an endangered species getting massively abused by the wellness "shaman" industry. It fucking sucks. Just use synthetic 5me0-dmt if you really must do a goofy vision quest larp.

martinky24•30m ago
Hmm. I am all for leaving animals alone, but their Wikipedia page says their status is “secure” and of “least concern”.

So yeah, let the frogs be, but I don’t think we should invent (hallucinate, in this case, perhaps?) reasons why…

mjmsmith•37m ago
Recently published, curious if anyone has read it: https://www.penguinrandomhouse.com/books/735472/the-ego-trip...
cammikebrown•22m ago
He wrote a nice New Yorker article a few years ago:

https://www.newyorker.com/magazine/2022/03/28/the-pied-piper...

bassiee•33m ago
HAMILTON,BUFOTENINE YOU NEED TO MAKE A VIDEO. xD

Anyone watch Hamiltons pharmacopeia

dennis_jeeves2•13m ago
I do.
martinky24•32m ago
Every time I find one of these in my backyard with my dog, I have to spray my dog’s mouth out with the hose for 5 minutes. Psychedelic, but also very toxic.
RajT88•26m ago
Find your soulmate, Homer!
juleiie•16m ago
People really overthink drugs.

You don't need anything more than psilocybin and some weed from time to time.

Anything else is just unnecessary noise and introduces vulnerabilities to your Fortress of Mind.

Backdoor here, trapdoor here, tunnel there. Before you know it, your psyche collapses under all the brain neuroplasticity. Mind cannot form any shape at all.

Truly terrible thought so be careful my people. Don't malleableize yourself into a goo.

natpalmer1776•14m ago
YMMV by person, their neurochemistry, and their living environment. I need a stimulant for my specific biology to adapt to modern expectations.

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The Psychedelic Toad of the Sonoran Desert

https://en.wikipedia.org/wiki/Bufo_Alvarius:_the_Psychedelic_Toad_of_the_Sonoran_Desert
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