Can anyone explain why the vaccine for TB works to treat bladder cancer?
The cytokines induce an inflammatory response, which I turn activates other immune system cells such as CD4 and CD8, NK cells and macrophages.
The immune cells then attack the bladder cancer cells, hopefully destroying them, thus "fighting cancer".
Source: Li J et al, NPJ Vaccines. 2021;6:14.
If half of people get rid of cancer for 1 year that is still outstanding - ESPECIALLY if the majority of those remain cancer free for quite some time after.
OS is more relevant than PFS
So something that cures half the patients and only requires an office or outpatient visit every few weeks (no surgery, no radiation) is astounding. This result will likely lead to further research using this approach.
2.See if your father qualifies for any
3. Enroll
4. Get B2 visa. All medical treatment is usually covered once you are accepted into the program.
good luck!
https://euclinicaltrials.eu/ctis-public/view/2023-507685-10-...
To be honest, chances are slim to none. But worth a try.
> https://www.sciencedirect.com/science/article/pii/S107814392...
> ...for individuals with high-risk non-muscle-invasive bladder cancer whose cancer had previously resisted treatment
I don't like headlines like this because they lack any necessary context. Knowing that a treatment eliminates cancer in 82% of patients isn't data unless we know more or already experts in this field. For all I know the previous treatment was 99% effective but just cost more or something. PR-style headlines very often use misleading statistics to get attention, so this wouldn't even be surprising.
- What was the previous treatment's success rate? Was it 22% or 81%?
- What are the other tradeoffs? If the previous treatment was also 82% maybe this one doesn't cause incontinence, or maybe it's non-invasive?
How you should make a title:
"New treatment eliminates cancer in 82% of patients, a major improvement"
"New treatment is first non-invasive way to eliminates cancer in 82% of patients"
"New treatment way to eliminates cancer in 82% of patients - without causing incontinence"
"New treatment eliminates cancer in 82% of patients without radiation"
newfocogi•4h ago
- "TAR-200 is a miniature, pretzel-shaped drug-device duo containing a chemotherapy drug, gemcitabine, which is inserted into the bladder through a catheter. Once inside the bladder, the TAR-200 slowly and consistently releases the gemcitabine into the organ for three weeks per treatment cycle."
- Phase 2 Clinical Trial
- 85 patients with high-risk non-muscle-invasive bladder cancer
- "treated patients with TAR-200 every three weeks for six months, and then four times a year for the next two years"
- 70/85 patients—the cancer disappeared and still gone 1yr later in almost 50% patients
- FDA granted TAR-200 a New Drug Application Priority Review
- Johnson & Johnson manufactures TAR-200
woeirua•3h ago
tptacek•3h ago
lordofgibbons•2h ago
tomsto•2h ago
codr7•1h ago
AnimalMuppet•1h ago
octaane•43m ago
ac2u•38m ago
The theory being that they could keep it at bay indefinitely and lower the chance of selection pressure kicking in. The thought behind their approach is that they wanted their patients to die of something different than their cancer.
apwell23•14m ago
Sometimes that resistance carries over to other lines too. For example, Enzalutamide doesn't work for prostate cancer if you were already treated by abiraterone.