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The Contagious Taste of Cancer

https://www.historytoday.com/archive/history-matters/contagious-taste-cancer
27•Thevet•23h ago

Comments

airstrike•1h ago
Holy nightmare fuel jumpscare. Why would someone do this but at the same time knowing humans of course someone would do this.
maxerickson•1h ago
In the case of transmissible diseases like smallpox, controlled exposure ends up being protective. It was widely practiced prior to development of modern vaccines.
ngruhn•1h ago
Newton poked a needle into his eye socket to study the resulting visual distortions. I'd rather lick the cancer juice.
golem14•15m ago
It was common until fairly recently that physicians would taste a patient’s urine to diagnose diabetes …
delichon•1h ago
Samuel Smith appears to have been infected by a fatal meme. I am obnoxiously in favor of free speech, but I can't deny ideas can kill in more ways than Chuck Norris.
mapontosevenths•45m ago
It is also possible that he was bound for his deathbed regardless, and confused correlation and causation here. Perhaps his desire to taste other people's cancer was an early symptom of some mental decline that had already started?

Doctors of that era, especially those who weren't too keen on hygiene, probably did not have exceptionally great life-spans.

mberning•1h ago
It doesn’t seem completely out of the question that he could have received a contagious cancer. There are examples in the animal world. I believe Tasmanian devils spread facial tumors through biting. And I have heard dogs have certain transmissible cancers as well.
mapontosevenths•51m ago
It stands to reason in my decidedly non-expert opinion. Many cancer cells have "forgotten" how to differentiate properly. Why should such a cell care if it's in the proper host any more than it cares it's in the proper place within that host?

I am a bit surprised that his own immune cells wouldn't stop it, but if cancer were easy for the immune system to deal with nobody would die of it.

sokols•19m ago
> but if cancer were easy for the immune system to deal with nobody would die of it.

This made me think, whether it would somehow make sense that cancer cells on another host would be detected by the immune system of that host. Theoretically, these immune cells have different “initialization parameters” so to say and maybe they could show affinity to the foreign cancer cells.

But then again I am not an expert and this is just a pure speculation.

golem14•14m ago
Healthy transplants from other organisms are also attacked…
pfdietz•13m ago
The dog cancer is not fatal though, I understand. The immune system does eventually fight it off.

Tasmanian devils apparently have little genetic diversity so they are more subject to this problem.

lebuffon•47m ago
We have one solid example of cancer caused by members of the HPV family. The disease can be transmitted via body fluids and/or contact. So there's that.

My laymans take: Cancer is a disease of the DNA of a cell. Viruses survive by altering cellular DNA. It begs the question: How many other viruses cause cancer?

It also seems clear to me that the virus may not be the sole cause since not everybody gets cancer so it is a multi-variable problem.

Virus + X = cancer

This will be harder to nail down but with modern data tools we should be able to get there.

Makes me wonder: Is the cancer "industry" searching for causes or just after-the-fact treatment?

maxerickson•33m ago
Makes me wonder: Is the cancer "industry" searching for causes or just after-the-fact treatment?

Why brag that you are uninformed?

Some of the more successful interventions for cancer are preventative (for example removing polyps during colonoscopies) and genetic counseling is common.

gww•12m ago
There are other examples of oncoviruses including: Epstein-Barr virus and Human herpes virus 8 (Kaposi's Sarcoma).

Makes me wonder: Is the cancer "industry" searching for causes or just after-the-fact treatment?

There are billions of dollars spent on this problem through huge DNA/RNA/Epigenomics/Chromatin Accessibility sequencing initiatives. There is also a huge amount of model system work such as mouse models.

renewiltord•9m ago
Why stop there? Perhaps we must recurse our conspiracy theories one level more: what if the faction of the cancer industry that wants after the fact treatment is propagating theories like yours so that they can make the cancer industry seem like all frauds and stop research until proven otherwise. Then they’ll be able to sell their current methods even longer.

Hmm, a disturbing and dangerous thought. But what does that mean for my comment? Who is paying me? What do they want? Will the lizard men of Hippocrates command the subtle ghasts of Papilla to inflict deep and lasting injury to our very souls?

Troubling. We must investigate.

idontknowmuch•7m ago
Viruses are just another "mutagen". No different from UV causing DNA damage in your skin cells, other than the mechanism in which it occurs. The cause for cancer is well-known and, in hindisght, obvious, which is mutation.

The challenge though is mutations can happen in a plethora of ways and their effect is highly dependent on which gene is mutated. There is also the tissue context, e.g. inflammation, spatial structure, etc., that can setup a background for increased mutation. That is why targeted therapies are often the most effective, because they target the general causative feature of a given tumour subtype, the problem is not every protein can be targeted now and each tumour, even within the same subtype has their own unique mutational profile due to the stochasticity of the way mutations occur over repeated rounds of cell division.

And back to viruses, yes they cause cancer because they can mutate DNA. But it's pretty clear, most of the viral "enriched" cancer types are generally in places where transmission is commonplace, e.g. reproductive organs or head/neck.

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The Contagious Taste of Cancer

https://www.historytoday.com/archive/history-matters/contagious-taste-cancer
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