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The Isomorphic Labs Drug Design Engine unlocks a new frontier beyond AlphaFold

https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier
30•andsoitis•2h ago

Comments

ashwon13•32m ago
Would like more details technically on their approach. Is it a neuro-symbolic approach, do they do something beyond just scaling, or some other architecture breakthrough, but alas drug discovery must remain proprietary. Thank gods for capitalism!
bonsai_spool•30m ago
This is from February 2026 and notably there’s no way for the public to try out the model, nor is it published in a peer-reviewed journal

Kaiser nurses say AI, workplace surveillance are making their jobs, care worse

https://localnewsmatters.org/2026/07/15/kaiser-nurses-say-ai-workplace-surveillance-are-making-th...
259•gnabgib•3h ago•151 comments

AWS: Inaccurate Estimated Billing Data – $1.7 billion

1044•nprateem•15h ago•638 comments

Thanks HN for 15 years of support and helping me find my life's work

307•nicholasjbs•8h ago•29 comments

The Zilog Z80 has turned 50

https://goliath32.com/blog/z80.html
161•st_goliath•5h ago•48 comments

The Isomorphic Labs Drug Design Engine unlocks a new frontier beyond AlphaFold

https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-fron...
30•andsoitis•2h ago•2 comments

First atmosphere found on Earth-like planet in habitable zone of distant star

https://www.bbc.com/news/articles/cy4kdd1e0ejo
363•neversaydie•11h ago•227 comments

DrDroid (YC W23) Is Hiring

https://www.ycombinator.com/companies/drdroid/jobs/w45QcNV-product-engineer-assignment-mandatory
1•TheBengaluruGuy•28m ago

Vāgdhenu: A Sanskrit Chanting TTS System

https://prathosh.in/vagdhenu/
36•subinalex•4d ago•2 comments

Learning a few things about running SQLite

https://jvns.ca/blog/2026/07/17/learning-about-running-sqlite/
160•surprisetalk•7h ago•39 comments

Kimi K3, and what we can still learn from the pelican benchmark

https://simonwillison.net/2026/Jul/16/kimi-k3/
276•droidjj•11h ago•144 comments

Texas wins court order to suspend domain name for violating age-verification law

https://www.texasattorneygeneral.gov/news/releases/attorney-general-ken-paxton-secures-landmark-l...
112•letmevoteplease•2h ago•120 comments

Static search trees: 40x faster than binary search (2024)

https://curiouscoding.nl/posts/static-search-tree/
44•lalitmaganti•5h ago•3 comments

Open Book Touch: open-source e-reader

https://www.crowdsupply.com/oddly-specific-objects/open-book-touch
52•surprisetalk•4h ago•12 comments

Topcoat: The full full-stack framework for Rust

https://github.com/tokio-rs/topcoat
36•wertyk•4h ago•24 comments

Painting the sides of railroad rails white to reduce derailment

https://www.up.com/news/safety/Tracking-Rail-Heat-260608
41•zdw•5h ago•12 comments

FAA lets Boeing sign off on 737 MAX, 787 airworthiness certificates again

https://www.cnbc.com/2026/07/17/faa-boeing-737-max-787.html
113•hmm37•4h ago•67 comments

Show HN: A zoomable timeline of 4M Wikipedia events

https://app.everything.diena.co/
56•lortex•6h ago•23 comments

The state of open source AI

https://stateofopensource.ai/
369•rellem•10h ago•269 comments

Lego building instructions through time

https://www.lego.com/en-us/history/articles/d-lego-building-instructions-through-time
56•NaOH•7h ago•9 comments

Frank Lloyd Wright’s first home

https://www.architecturaldigest.com/story/frank-lloyd-wright-home-and-studio-everything-you-need-...
77•NaOH•4d ago•41 comments

"Disk Not Ejected Properly": What It Means

https://bombich.com/blog/2026/07/07/disk-not-ejected-properly
25•speckx•1w ago•7 comments

Show HN: Instrumation a PYPI library for Instruments

https://github.com/abduznik/instrumation
3•abduznik•5d ago•1 comments

MoonBASIC: A modern BASIC for building 2D and 3D games

https://github.com/CharmingBlaze/moonbasic
50•klaussilveira•3d ago•13 comments

TP-Link Kasa cameras leaked home GPS via unauthenticated UDP for 6 years

https://github.com/BadChemical/IoT-Vulnerability-Research-Public/blob/main/TP-Link_Kasa_EC71/Kasa...
15•BadChemical•3h ago•1 comments

Three ways people respond to a problem (other than solving it)

https://improvesomething.today/responses-to-problems/
193•surprisetalk•11h ago•113 comments

Show HN: Watch bots interact with an SSH honeypot in real time

https://honeypotlive.cc/
139•tusksm•11h ago•49 comments

More Bounce to the Ounce

https://mceglowski.substack.com/p/more-bounce-to-the-ounce
109•pavel_lishin•11h ago•45 comments

Designing emoji for the way we communicate today

https://blog.google/products-and-platforms/platforms/android/world-emoji-day-noto-3d/
55•pentagrama•9h ago•74 comments

AI Meets Cryptography 2: What AI Found in OpenVM's ZkVM

https://blog.zksecurity.xyz/posts/openvm-bugs/
83•duha•11h ago•6 comments

Evidence of inconsistencies in evaluation process and selection of winners

https://www.kaggle.com/competitions/kaggle-measuring-agi/discussion/724918#3498423
443•twerkmeister•13h ago•276 comments