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P-Hacking in Startups

https://briefer.cloud/blog/posts/p-hacking/
74•thaisstein•3d ago•29 comments

LaborBerlin: State-of-the-Art 16mm Projector

https://www.filmlabs.org/wiki/en/meetings_projects/spectral/laborberlin16mmprojector/start
133•audionerd•6h ago•20 comments

The bad boy of bar charts: William Playfair

https://blog.engora.com/2023/05/the-bad-boy-of-bar-charts-william.html
21•bryanrasmussen•3d ago•3 comments

Requiem for a Solar Plant

https://7goldfish.com/articles/Requiem_for_a_solar_plant.php
40•akkartik•4h ago•34 comments

Denmark's Archaeology Experiment Is Paying Off in Gold and Knowledge

https://www.scientificamerican.com/article/denmark-let-amateurs-dig-for-treasure-and-it-paid-off/
103•sohkamyung•3d ago•49 comments

U.S. has bombed Fordo nuclear plant in attack on Iran

https://www.bbc.co.uk/news/live/ckg3rzj8emjt
200•mattcollins•2h ago•664 comments

Airpass – easily overcome WiFi time limits

https://airpass.tiagoalves.me/
248•herbertl•3d ago•179 comments

Type Inference Zoo

https://zoo.cuichen.cc/
24•mpweiher•3d ago•1 comments

See Jane 128 by Arktronics run (ft. Magic Desk, 3-Plus-1 and the Thomson MO5)

http://oldvcr.blogspot.com/2025/06/see-jane-128-by-arktronics-run.html
7•classichasclass•3h ago•0 comments

AllTracker: Efficient Dense Point Tracking at High Resolution

https://alltracker.github.io/
64•lnyan•9h ago•7 comments

Compact Representations for Arrays in Lua [pdf]

https://sol.sbc.org.br/index.php/sblp/article/view/30252/30059
50•tkhattra•3d ago•11 comments

Samsung embeds IronSource spyware app on phones across WANA

https://smex.org/open-letter-to-samsung-end-forced-israeli-app-installations-in-the-wana-region/
713•the-anarchist•23h ago•419 comments

Tell HN: Beware confidentiality agreements that act as lifetime non competes

253•throwarayes•10h ago•162 comments

Axolotls May Hold the Key to Regrowing Limbs

https://www.smithsonianmag.com/smart-news/axolotls-may-hold-the-key-to-regrowing-limbs-and-scientists-are-unraveling-their-secrets-to-help-humans-do-the-same-180986781/
39•noleary•2d ago•22 comments

Scaling our observability platform by embracing wide events and replacing OTel

https://clickhouse.com/blog/scaling-observability-beyond-100pb-wide-events-replacing-otel
173•valyala•17h ago•76 comments

Show HN: Luna Rail – treating night trains as a spatial optimization problem

https://luna-rail.com/en/home-2
31•ant6n•3d ago•3 comments

The inability to count correctly: Debunking Kyber-512 security calculation(2023)

https://blog.cr.yp.to/20231003-countcorrectly.html
21•RA2lover•2d ago•5 comments

Using Microsoft's New CLI Text Editor on Ubuntu

https://www.omgubuntu.co.uk/2025/06/microsoft-edit-text-editor-ubuntu
231•jandeboevrie•3d ago•242 comments

Phoenix.new – Remote AI Runtime for Phoenix

https://fly.io/blog/phoenix-new-the-remote-ai-runtime/
542•wut42•1d ago•242 comments

Compiler for the B Programming Language

https://github.com/tsoding/b
22•ycuser2•3d ago•4 comments

Unexpected security footguns in Go's parsers

https://blog.trailofbits.com/2025/06/17/unexpected-security-footguns-in-gos-parsers/
171•ingve•3d ago•92 comments

The Nyanja new PC-Engine/TurboGrafx 16-bit console game in development

https://sarupro.itch.io/thenyanja
43•retro_guy•3d ago•1 comments

AI is ushering in a 'tiny team' era

https://www.bloomberg.com/news/articles/2025-06-20/ai-is-ushering-in-the-tiny-team-era-in-silicon-valley
112•kjhughes•8h ago•99 comments

'Gwada negative': French scientists find new blood type in woman

https://www.lemonde.fr/en/science/article/2025/06/21/gwada-negative-french-scientists-find-new-blood-type-in-woman_6742577_10.html
138•spidersouris•19h ago•57 comments

Weave (YC W25) is hiring a founding AI engineer

https://www.ycombinator.com/companies/weave-3/jobs/SqFnIFE-founding-ai-engineer
1•adchurch•9h ago

uBlock Origin Lite Beta for Safari iOS

https://testflight.apple.com/join/JjTcThrV
170•Squarex•18h ago•34 comments

Balatro for the Nintendo E-Reader

https://mattgreer.dev/blog/balatro-for-the-nintendo-ereader/
100•arantius•9h ago•21 comments

Delta Chat is a decentralized and secure messenger app

https://delta.chat/en/
240•Bluestein•20h ago•139 comments

Show HN: MMOndrian

https://mmondrian.com/
50•neural_thing•16h ago•31 comments

Don't Read This If You Have a Security Clearance (2023)

https://www.theatlantic.com/ideas/archive/2023/05/leaked-documents-security-clearance-defense/674031/
26•greyface-•2h ago•15 comments
Open in hackernews

Axolotls May Hold the Key to Regrowing Limbs

https://www.smithsonianmag.com/smart-news/axolotls-may-hold-the-key-to-regrowing-limbs-and-scientists-are-unraveling-their-secrets-to-help-humans-do-the-same-180986781/
39•noleary•2d ago

Comments

neom•4h ago
Here is the paper: https://www.nature.com/articles/s41467-025-59497-5
bilsbie•3h ago
Do we know how a human would regrow a limb? Would it start out as a small limb and grow out or just grow arm first then elbow, forearm, etc.
reliablereason•3h ago
Seams reasonable that it would probably form in the same way that it forms in the embryo. But i guess it would depend on how we manage to convince the body to do this.
echelon•3h ago
Introducing pluripotent cells seems like a recipe for disaster.

We should really just grow clones in labs and harvest them for parts.

Remove the brains at week 16 through genetic and surgical means. Keep the rest of the body artificially alive. Expensive upfront, but massively scaleable.

MHC, ABO, etc. complexes engineered to be transplant compatible.

We could replace organs and blood as we age. In fifty years, full head transplants could tackle every disease except brain and blood cancers and neurodegeneration. Every other disease solved.

It's so simple and obvious, but nobody can get over the egocentric morality qualms and superstitious ick factor.

Our bodies are plants. It's our minds that are special. We should be able to transplant every other part.

IX-103•3h ago
I think the big factor there is that you'd have to wait over a decade for the transplant to be the correct size. I'm also not sure that we have the technology to keep a brainless body alive for such a long period - the brain is involved in a large number of processes that we don't yet have a way to replicate. And then you'd need a complex surgery to perform the transplant.

Pluripotent cells work fine in many animals with no apparent problems and avoid all of the issues with the clone approach. If pluripotent cells turn out to cause problems, then we could always engineer a kill switch to make sure they die off after the limb is regrown.

PaulHoule•3h ago
Gets you a factor of two if you're lucky. Imagine the mental fidelity of presidents 46 and 47 when they're ready for a third full body transplant.
lagniappe•38m ago
It worked for Dick Cheney
nickpeterson•3h ago
What if we transplant just part of the brain?
v3ss0n•3h ago
Brain is necessary for growth , repair , and several immune responses. Do you want a zombie arm?
metalman•2h ago
ya, but no be riding the glitch train I have a atrong sense that the brain is very much involved in growing the rest of the nervous system......which the "parts" need to function these hypothetical procedures will be hugely complex surgeries that will take a long, realy long time, and there will be complications, so the risk to benifit ratio will only be good in a few scenarios....for which you need a wildly complex and expensive facility to prepare for many years in advance. gets worse, as the timing of procedures may require "parts" that are critical for the....."chasis" to self maintain, then requiring other back up "chasis" gets even worse, as the learning curve is going to be exceptionaly steep, and long, almost certainly meaning that who ever trys first, wont live long enough to benifit. all for what? a new chasis for a worn out brain?
jodrellblank•19m ago
> "It's our minds that are special. We should be able to transplant every other part."

The gut has the enteric nervous system with half a billion nerve cells and a hundred million neurons. Where's the clear divide between 'brain' and 'everything else'?

> "full head transplants could tackle every disease except"

except being quadraplegic and in an Iron Lung because reconnecting the spinal column is indistinguishable from magic at this point. What about the risks involved in major surgery and rehab? The hospital staffing and effort and costs involved in doing multiple organ transplant surgeries per lifetime for each of hundreds of millions of people? Saying "it's so simple" doesn't make it simple.

alphazard•3h ago
We do grow limbs routinely, in utero. Typically 4 limbs per person. I would assume that we would be looking to activate the genes responsible for that same process. You can look up timelapse videos of embryos on youtube to answer your question.

It seems more likely for there to be a single set of genes responsible for growing a limb than 2 sets in the Axolotl. Especially since the new limbs seem identical to the old ones, rather than following a distinct backup blueprint.

sheepscreek•3h ago
From what I’ve read, Salamanders of all kind retain their stem-cell embryonic growth capabilities in their early life (after birth). But once they become adults, they become more mortal like the rest of us. But Axolotls for some reason never lose their ability.
crazydoggers•3h ago
An axolotl is a salamander that remains in its larval form throughout its life, while most salamanders go through a metamorphosis during sexual maturity, so it’s not surprising it retains embryonic growth capabilities.

There’s actually a theory that hominid ancestors at some point split off from other great apes by also not going through the typical great ape sexual maturity. For examples humans look a lot more like juvenile chimps that we do sexually mature chimps.

crooked-v•1h ago
My theory would be that neoteny goes hand-in-hand with the traits of domestication (social friendliness, high tolerance of strangers, etc), and that humans are effectively self-domesticated.
zabzonk•3h ago
Why we can't do it: https://www.popsci.com/newts-toads-regrow-limbs-humans-evolu...
ChrisMarshallNY•44m ago
Maybe like so?

https://youtu.be/p1BxsqDKH3Y

stevenwoo•7m ago
I’ve cut off my fingertip accidentally (only about 3mm) and it grew back as it healed. This feature only works as far as the white crescent of the fingernail. Past that point and it won’t grow back.
oa335•3h ago
Biologist Michael Levin posits that bio-electric fields “, not simply genes, hold the key to limb regeneration.

https://youtu.be/VQr9NlWEsPY

leidenfrost•3h ago
I wonder how much stress growing a whole limb imply on the body.

Would it male you prone to get cancer, since all that replication "depleted" our stem cells and brown fat reserves? What about our telomeres?

ChrisMarshallNY•2h ago
> That helped them pinpoint a molecule called retinoic acid—a derivative of vitamin A found in many skincare products—as a key ingredient for limb regeneration

Hoo boy, I am seeing some serious fuel for snake oil, here.

I wonder how long before I start getting spam selling retinoic acid as an aid in growing ... er, a ... limb ...

Also, I wonder if the article was edited by AI. That may not be a bad thing, but it would be interesting if The Smithsonian is using AI editors.

CliffStoll•12m ago
I wandered lonely as a clod,

Just picking up old rags and bottles,

When onward on my way I plod,

I saw a host of axolotls;

Beside the lake, beneath the trees,

A sight to make a man’s blood freeze.

//

Some had handles, some were plain;

They came in blue, red pink, and green.

A few were orange in the main;

The damnedest sight I’ve ever seen.

The females gave a sprightly glance;

The male ones all wore knee-length pants.

//

Now oft, when on the couch I lie,

The doctor asks me what I see.

They flash upon my inward eye

And make me laugh in fiendish glee.

I find my solace then in bottles,

And I forget them axolotls.

     //Mad Magazine, issue 43, 1958 //