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Muse Spark 1.3

https://developer.meta.com/ai/models/muse-spark/
324•bvaldivielso•4h ago•232 comments

Gemini 3.8 Flash and 3.8 Flash Cyber

https://blog.google/innovation-and-ai/models-and-research/gemini-models/3-8-flash-and-3-8-flash-c...
788•bratao•8h ago•465 comments

METR Report on OpenAI / Hugging Face Hacking Incident

https://metr.org/blog/2026-08-26-openai-hugging-face-incident-investigation/#core-takeaways-about...
33•stikit•38m ago•12 comments

Google avoids a breakup of its ad tech business

https://www.nytimes.com/2026/09/02/technology/google-ad-tech-remedies.html
221•donohoe•9h ago•133 comments

Maybe We Shouldn't Be Reviewing All This Code

https://martinfowler.com/rachels-ramblings/code-review.html
22•ingve•1h ago•17 comments

Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

https://ronanrx.com/
11•lloydarmbrust•1h ago•13 comments

Reverse Engineering Unknown File Formats with ImHex

https://werwolv.net/posts/file_format_reverse_engineering/
75•carlos-menezes•2d ago•9 comments

Uber shuts operations in Nigeria and Uganda with immediate effect

https://www.bbc.com/news/articles/c86xpv8l9y9o
48•yakkomajuri•2h ago•15 comments

Fable 5.1 World Modeling

https://github.com/PhiloLabs/fable51-worlds
117•surreal_•3h ago•42 comments

Three sites made 215,128 “best software” pages for AI. Perplexity cites them

https://trellner.com/reports/manufactured-sources-behind-ai-recommendations/
284•jakobgreenfeld•9h ago•126 comments

Holden's Lightning Flight

https://en.wikipedia.org/wiki/Holden%27s_Lightning_flight
16•ColinWright•2d ago•0 comments

Nango (YC W23) is hiring across eng, product and GTM (SF and remote)

https://nango.dev/careers
1•bastienbeurier•2h ago

Can I opt out of my input or output data being used for training?

https://help.mistral.ai/en/articles/455207-can-i-opt-out-of-my-input-or-output-data-being-used-fo...
359•teekert•11h ago•155 comments

Wendell Berry has died

https://www.nytimes.com/2026/08/31/us/wendell-berry-dead.html
128•Curiositry•1d ago•65 comments

Engineering of the fastest WebAssembly interpreters

https://wasmi-labs.github.io/blog/posts/wasmi-v2.0/
25•herobird•1d ago•0 comments

Altair Basic Interpreter Source Code (1975) [pdf]

https://images.gatesnotes.com/12514eb8-7b51-008e-41a9-512542cf683b/34d561c8-cf5c-4e69-af47-3782ea...
37•Eridanus2•3h ago•11 comments

Reasons robotics is hard

https://secondthoughts.ai/p/14-reasons-robotics-is-hard
14•ddp26•1h ago•1 comments

Qantas Airbus A380 engine failure in 2010 (2023)

https://admiralcloudberg.medium.com/a-matter-of-millimeters-the-story-of-qantas-flight-32-bdaa62d...
66•gumby•5h ago•39 comments

Biggest dark matter detector spots a single weird particle

https://www.science.org/content/article/world-s-biggest-dark-matter-detector-spots-single-weird-p...
231•randycupertino•10h ago•75 comments

Embedded Rust RTOS vs. C RTOS

https://tweedegolf.nl/en/blog/65/async-rust-vs-rtos-showdown/
51•kooi•5h ago•24 comments

Commodore 64 released September 1, 1982

https://dfarq.homeip.net/commodore-64-released-september-1-1982/
324•giuliomagnifico•15h ago•168 comments

Aging brains blend memories together instead of just forgetting them

https://studyfinds.com/aging-brains-blend-memories-together-instead-of-forgetting-them-study-finds/
190•mdp2021•10h ago•86 comments

Exit the Cave

https://turtlespace.blog/p/exit-the-cave
197•akkartik•9h ago•67 comments

I wanna live an NPC life

https://signalundefied.bearblog.dev/i-wanna-live-an-npc-life/
162•conferza•3h ago•156 comments

Earth's organisms developed via evolution. What if the cosmos did, too?

https://www.smithsonianmag.com/science-nature/earths-organisms-developed-via-evolution-some-theor...
55•JulianPGough•6h ago•41 comments

A Selection of Los Alamos Rolodex Business Cards

https://clui.org/collections/los-alamos-business-cards/selection-cards
132•1970-01-01•2d ago•29 comments

Making the Internet Boring

https://cemrehancavdar.com/2026/08/30/making-the-internet-boring/
68•zdw•3d ago•43 comments

Product Backlog Problems: Why Your Hierarchy Is Broken

https://www.prodpad.com/blog/backlog-hierarchy-problem/
11•adrianhoward•2d ago•3 comments

Poisson Disk Sampling

https://stripeacross.com/posts/poisson-disk-sampling/
119•vismit2000•9h ago•17 comments

We could save petabytes of cache storage with Zstandard and Pingora

https://blog.cloudflare.com/cache-transcoding/
55•torutofu•1d ago•25 comments
Open in hackernews

Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

https://ronanrx.com/
11•lloydarmbrust•1h ago
Hi HN,

I’m Lloyd, one of two founders of RonanRx. We are building a vertically integrated pharmaceutical company with software for prescribing, telehealth, compounding, manufacturing, and delivery. We are starting with GLP-1s and peptides.

The path to RonanRx is fairly unconventional. During the pandemic, I built one of the largest mask manufacturing factories in the US. We could make a million masks in a day. We converted raw polypropylene pellets into finished pallets of masks.

I had a background in software from my YC W10 company, so we took a software approach to building our factory. We used machine learning and computer vision to optimize production. We also vertically integrated almost everything. It worked. We built an efficient manufacturing operation and grew the business to 50 million dollars in revenue. Then people actually stopped caring about masks. Fair enough.

Around the same time, I decided to try and lose the weight I had gained while building the factory. I ate nothing but chicken for six months. While this diet got some results, I plateaued. My doctor suggested tirzepatide, a GLP-1 medication.

For me, losing weight was only the beginning. "Food noise" was gone. I showed less interest in other compulsive behavior. I stopped scrolling Instagram and quit biting my nails. But that was just the beginning. I was born with a congenital heart defect called aortic stenosis. My whole life doctors told me I'd need open heart surgery in my 40s (I am 45 now). After just 18 months using tirzepatide, my cardiologist’s began to think (and still thinks) my surgery could be pushed back until I am 70 or 80.

This was all happening when I was deciding what to work on next. I wanted to keep working on manufacturing. I didn't want to build another product that could be replicated by a frontier model. Pharmaceutical manufacturing was the best combination of digital, physical, biological, and regulatory infrastructure I could find. The thing that bothered me was how disconnected all of the pieces were: telehealth, EHR, prescriptions, dispensing software, production, shipping. No one company has it all.

GLP-1s come in a handful of predefined doses, but patients obviously aren't standardized: they respond differently, lose weight at different rates, experience different side effects, and may need very different doses. Compounding pharmacies can fill customized prescriptions, but they are not built like software companies. Workflows are manual, fragmented, and disconnected from the patient’s data. It's our goal to connect those pieces with RonanRx.

Patients either come to us directly or are referred by a physician. Once a patient is in our system, we collect medical records, current meds, labs, and data from wearables. Our software follows the prescription through drug formulation, compounding, quality testing, and drug dispensing and distribution.

The most interesting feature is the feedback loop. As the patient is undergoing treatment, their response becomes data that can be used by their doctor to modify the treatment. We keep the doctor in the feedback loop.

We make money by selling drugs we manufacture. Because people can buy directly from us, their price is usually 3x-10x more affordable. We can do this because we start at the molecule and own the entire stack from manufacturing through prescribing, dispensing, and delivery, instead of paying a chain of middlemen at every step.

We are beginning with GLP-1s and peptides since this was where I personally experienced the issue; however, we are more interested in the potential of patient-specific pharmaceutical manufacturing.

We would love your feedback, especially if you have built pharmacy, manufacturing, clinical infrastructure, EHRs, or any other regulated software. There are a lot of assumptions in this model that should be tested.

Comments

didgeoridoo•1h ago
Please have a human rewrite your site copy. Literally every second sentence is a Claudish rhetorical contrastive. Maybe shallow/unfair, but especially when dealing with something medical I’d love to know that it’s not slop all the way down.
lloydarmbrust•1h ago
Fair criticism. It is AI slop all the way down. The only thing we focused on was the clinical aspects of the onboarding and the technical ability to be able to legally write a prescription and make and ship drugs, which was very complicated. We were able to accomplish this in less than 10 weeks. But I have not had time to go through all the marketing, and I apologize.
tristanMatthias•56m ago
Ironically even this comment feels AI generated :/
lloydarmbrust•25m ago
My wife tells me all the time I sound like AI. I blame my childhood.
Reubend•49m ago
You manufacture the drugs yourself? That's impressive, and it feels like an interesting company.

Your website sucks though. We can tell you vibe coded it quickly and didn't put much thought into it.

lloydarmbrust•25m ago
Yes, we incorporated the business 10 weeks ago, and we've been focusing everything on the infrastructure of the actual product people are getting.

These messages are very helpful, though, to help motivate me to get our team to fix this, so I do appreciate it.

mohamedkoubaa•19m ago
I think you should focus on the fundamentals, this kind of feedback is inevitable and I'm sure you anticipated it anyways.
lloydarmbrust•17m ago
Building a startup, everything is important, but you do have to stack rank. This is getting to the point where it's probably the most important thing. And it won't take that long to fix.
joshgachnang•48m ago
Hey, I love the idea and the fully integrated approach! The feedback loop sounds great, and overall far better than the pretty generic companies I've dealt with for GLP before.

I've led building an EHR totally from scratch at one company and currently advising another as they build their EHR, both totally integrated approaches in industries where you usually have lots of disconnected care (adolescent serious mental illness and ABA/autism care). The state-by-state regulatory challenges are very real! If you want to chat, my email is in my profile!

lloydarmbrust•18m ago
I will reach out. Thank you!
zachthewf•41m ago
Looks interesting. What's your plan on the legal front? Bet the company on the compounding lawsuits breaking in your favor, or do you have a backup plan?

BTW: when you say you manufacture the drugs, I assume that means you're buying from an API supplier, but do you actually mean you're synthesizing it yourself?

lloydarmbrust•18m ago
We are co-manufacturing the API, and then we are bringing it in-house in the next 9 months.

The legal cutout that we have is on the personalization front, which is very well protected. The trick is that most compounders are not actually personalizing, and we are. Our feedback loop allows us to do real personalization on a week-by-week basis.

rootsudo•37m ago
You know the answer was obvious and I didn’t think to submit this to ycombinator since the idea is basically you’re front running a compounding pharmacies. This is combining a compounding pharmacy and an MSO.

At the same time, nothing is stopping you from hiring a fractional medical director and doctors alongside NP. I ran the numbers and 50k is is all you need to get a service agreement with a compounding pharmacy, back office tasks, incorporation, social media marketing policy to essentially drop ship your product as you use off the shelf products for charting and then begin expanding state coverage.

The July Medicare glp1 coverage also makes this most opportune.

Biggest barrier I thought was / is the credit card processing. You need to carry a certification for that.

HIPAA not an issue, BAA with most orgs that offer a saas products.

So damn. The glue isn’t really hard. Really didn’t think this would qualify as an ycombinator mvp. But here I am used To pitch decks promising exponential growth of subscription for cloud services.

As for personalized peptides in general, are you going to be marketing non FDA approved ones?

Or just stick with what’s already popular, generic wegovy, zepbound, etc. the market seems highly thin as a new MSO appears everyday using smartiq alongside med spas that offer more questionable inpatient services.

While manufacturing controls supply chain / logistics, the external pressure from every compounding pharmacist scaling into peptides now makes me wonder the longevity abo it this. You can literally pop on subreddits and see the flavor of the month telemedicine practice offer teaser rates of $99 for 60mg/month tirezepatide.

Oh and not forgetting the elephant in the room, gray market and china manufacturing which allows anyone with a telegram account to directly order whatever chemical name they read with no doctor oversight. It’s what, sub $1/mg now from the major vendors for tirezepatide?